Mikkel Werge

Investigation of non-invasive tests for fibrosis diagnosis and prognostication of events in metabolic dysfunction-associated steatotic liver disease: A prospective study cohort

Marie Louise N. Therkelsen, Liv Eline Hetland, Mikkel Werge, Mira Thing et autres

INTRODUCTION AND OBJECTIVES: Risk stratification is important in the management of metabolic dysfunction-associated steatotic liver disease (MASLD) to prioritize monitoring and treatment resources. We evaluated whether non-invasive tests (NITs) can predict major adverse liver outcomes (MALOs) and diagnose advanced fibrosis in patients …

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Decoding fibrosis: Transcriptomic and clinical insights via AI-derived collagen deposition phenotypes in MASLD

Marta Wojciechowska, Mira Thing, Yang Hu, Gianluca Mazzoni et autres

Abstract Histological assessment is foundational to multi-omics studies of liver disease, yet conventional fibrosis staging lacks resolution, and quantitative metrics like collagen proportionate area (CPA) fail to capture tissue architecture. While recent AI-driven approaches offer improved precision, they are proprietary and not …

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Magnetic resonance imaging-derived extracellular volume fraction mapping in metabolic dysfunction-associated steatotic liver disease reveals subclinical cardiac remodelling

P N Puria Nabilou, Signe Wiese, Liv E. Hetland, Mikkel Werge et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a systemic fibroinflammatory condition with elevated cardiovascular risk. This study primarily evaluated cardiac fibrosis using MRI-derived extracellular volume fraction (ECV), with hepatic and pancreatic fibrosis assessed as secondary aims, examining whether ECV mapping of the …

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Early Identification of At-Risk Patients: Proteomic Signature Predicts Progression to Decompensated Cirrhosis

Marie Louise N. Therkelsen, Nicolai J. Wewer Albrechtsen, Mikkel Werge, Mira Thing et autres

Abstract Background & Aims Early identification of decompensation in patients with cirrhosis is important to enable timely detection, management of complications and for effective treatment. This study investigates the biology of decompensation and aim to identify protein biomarkers for identification of high-risk …

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Prospective long-term assessment of pulmonary impairment in chronic pancreatitis: A comparative study with healthy controls (RespPanc)

Amer Hadi, Mikkel Werge, Lise Lotte Gluud, Ejvind Frausing et autres

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Role of bioimpedance spectroscopy analysis to assess hydration status in the early phase of acute pancreatitis

Morten Laksáfoss Lauritsen, Mikkel Werge, Mirjana Cihoric, Henrik L. Jørgensen et autres

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Response to Letter to Editor “Accurately Predicting Outcomes in Acute Necrotizing Pancreatitis With Walled-Off Necrosis Patients” by Shangzhu Chen and Chengdong Tang

Mohamed Ebrahim, Mikkel Werge, Srdan Novovic, Nadia Emad Lotfi Amin et autres

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Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Anne‐Sofie H. Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Werge et autres

BACKGROUND: Autoimmune hepatitis (AIH) may be difficult to diagnose and distinguish clinically and biochemically from other chronic liver diseases like metabolic dysfunction-associated steatotic liver disease (MASLD). AIMS: To identify pathways involved in the pathogenesis and identify disease-specific biomarkers of AIH. METHODS: We …

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Alterations in one-carbon metabolism in metabolic dysfunction associated steatotic liver disease may be modified by semaglutide

Mikkel Werge, Adrian McCann, Elias B. Rashu, Shi Lam et autres

INTRODUCTION AND OBJECTIVES: Disruptions in one-carbon metabolism (OCM) have been linked to cardiometabolic diseases. We evaluated alterations in OCM metabolites and enzymes and the impact of semaglutide in MASLD. MATERIALS AND METHODS: Using targeted metabolomics and bulk-transcriptomics, we analyzed components of OCM …

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The hepatic transcriptome is differentially regulated by a standardized meal in healthy individuals compared to patients with fatty liver disease

Josephine Grandt, Christian D. Johansen, Anne‐Sofie H. Jensen, Mikkel Werge et autres

The human liver is dynamic organ with minute to hourly adaptions in response to feeding. Patients with non-alcoholic fatty liver disease (NAFLD) and cirrhosis have altered transcriptomic features compared to controls but how and if food intake affects such is unknown in …

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THU-278 Clinical diagnostics of autoimmune hepatitis enabled by mass spectrometry-based proteomics

Anne-Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Werge et autres

OS-080-YI Multimodal single-nuclei atlas of MASLD progression uncovers a link to type 2 diabetes

Laura Pikkupera, Rikard G. Fred, Malte Thodberg, Thomas Koefoed et autres