Elizabeth G. Smith

Aberrant Neural Entrainment to Word‐Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit

Laura J. Batterink, Yanchen Liu, Grace C. Westerkamp, Jae Citarella et autres

Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from sensory input through mere exposure and plays a central role …

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Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome

Rana Elmaghraby, Yanchen Liu, P. S. Ramesh, Grace C. Westerkamp et autres

BACKGROUND: Fragile X syndrome (FXS) is characterized by cortical hyperexcitability, a core neurophysiological feature that contributes to sensory hypersensitivity, cognitive dysfunction, and other disabling symptoms. This disruption in excitatory-inhibitory balance is a key pharmacological target, yet reliable biomarkers to quantify it noninvasively …

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FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions

Jae Citarella, Peyton Siekierski, Lauren E. Ethridge, Grace C. Westerkamp et autres

gene, is characterized by varying degrees of intellectual disability, autistic features, and sensory hypersensitivity. Despite phenotypic rescue in animal deletion models, clinical trials in humans have been unsuccessful, likely due to the heterogeneous nature of FXS. To uncover the basis of individual- …

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Frontal cortex hyperactivation and gamma desynchrony in Fragile X syndrome: Correlates of auditory hypersensitivity

Ernest V. Pedapati, Lauren E. Ethridge, Yanchen Liu, Rui Liu et autres

Fragile X syndrome (FXS) is an X-linked disorder that often leads to intellectual disability, anxiety, and sensory hypersensitivity. While sound sensitivity (hyperacusis) is a distressing symptom in FXS, its neural basis is not well understood. It is postulated that hyperacusis may stem …

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Navigating Neuroimaging Challenges in Rare Neurogenetic Disorders: A Case Example From Girls With Fragile X Syndrome

Lauren Schmitt, Elizabeth G. Smith

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Brain Morphometry of Toddlers With Language Delay: An Exploratory Study

Courtney A. Filippi, Elizabeth G. Smith, Elizabeth Redcay, Heather C. Hazlett et autres

ABSTRACT While studies have documented neural correlates of language delay in toddlers with developmental conditions, those at genetic risk for language delay, and those born premature, no studies have examined neural correlates in toddlers exhibiting early language delay without known aetiology. This …

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Specialization of the brain for language in children with Fragile X Syndrome: a functional Near Infrared Spectroscopy study

Elizabeth G. Smith, Kelli C. Dominick, Lauren Schmitt, Ernest V. Pedapati et autres

Specialization of the brain for language is early emerging and essential for language learning in young children. Fragile X Syndrome (FXS) is a neurogenetic disorder marked by high rates of delays in both expressive and receptive language, but neural activation patterns during …

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Towards realist-informed ripple effects mapping (RREM): positioning the approach

Kevin Harris, James David Nobles, Louis Ryan, Christoph Szedlak et autres

BACKGROUND: Evaluation approaches such as ripple effects mapping (REM) and realist evaluation have emerged as popular methodologies to evidence impact, and the processes of change within public health as part of whole systems approaches. Despite the various examples of their implementation across …

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Author response for "Brain Morphometry of Toddlers With Language Delay: An Exploratory Study"

Courtney A. Filippi, Elizabeth G. Smith, Elizabeth Redcay, Heather C. Hazlett et autres

Author response for "Brain Morphometry of Toddlers With Language Delay: An Exploratory Study"

Courtney A. Filippi, Elizabeth G. Smith, Elizabeth Redcay, Heather C. Hazlett et autres

Author response for "Brain Morphometry of Toddlers With Language Delay: An Exploratory Study"

Courtney A. Filippi, Elizabeth G. Smith, Elizabeth Redcay, Heather C. Hazlett et autres

Frontal Cortex Hyperactivation and Gamma Desynchrony in Fragile X Syndrome: Correlates of Auditory Hypersensitivity

Ernest V. Pedapati, Lauren E. Ethridge, Yanchen Liu, Rui Liu et autres

Fragile X syndrome (FXS) is an X-linked disorder that often leads to intellectual disability, anxiety, and sensory hypersensitivity. While sound sensitivity (hyperacusis) is a distressing symptom in FXS, its neural basis is not well understood. It is postulated that hyperacusis may stem …

us, gb (code pays fourni par la source)