Lauren E. Ethridge

Aberrant Neural Entrainment to Word‐Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit

Laura Batterink, Yanchen Liu, Grace Westerkamp, Jae Citarella et autres

Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from sensory input through mere exposure and plays a central role …

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Aberrant Neural Entrainment to Word‐Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit

Laura Batterink, Yanchen Liu, Grace Westerkamp, Jae Citarella et autres

Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from sensory input through mere exposure and plays a central role …

Reliable but Wrong? Automated Detection of Heart Rate Artifacts as a Source of Bias in Pediatric EEG Data

Brenna Arledge, Tori Hollen, Akhila K. Nekkanti, Elizabeth A. Skowron et autres

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Neural Responses to Social Rejection in Rural Communities: a Cross-Sectional EEG Study of Adverse Childhood Experiences and Protective Factors

Brenna Arledge, Sarah Beth Bell, Constance Chapple, Erin Maher et autres

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Elevated gamma spectral event peak power during auditory chirp is associated with neuropsychiatric features in Fragile X syndrome

Y. Liu, Peyton Siekierski, Lisa A. De Stefano, Grace Westerkamp et autres

• Elevated gamma event peak power drives elevated gamma activity in males with Fragile X Syndrome (FXS) during auditory chirp. • Gamma event peak power is dissociated from phase synchronization in FXS, suggesting altered gamma generation mechanisms. • Gamma event peak power …

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Selective Disruption of Salience‐Network Anterior Insula Connectivity in Misophonia: A Disorder‐Specific Neural Signature

Heather A. Hansen, Jordan E. Norris, Catherine Bain, Lauren E. Ethridge et autres

Misophonia, a disorder characterized by extreme aversion to certain sounds, affects 5%-20% of the general population, yet mechanisms are still largely unknown. Recent neuroimaging studies have reported abnormal functional connectivity of the anterior insula to various limbic, salience, and motor regions in …

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A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice

Sara S. Kornfeld-Sylla, Çiğdem Gelegen, Jordan E. Norris, Francesca A. Chaloner et autres

Abstract Predicting clinical therapeutic outcomes from animal studies using conserved electrophysiological phenotypes could facilitate developing treatments for neuropsychiatric disorders. Alpha oscillations in human resting-state electroencephalogram recordings are altered in many disorders, but whether these disruptions exist in mouse models is unknown. Here, …

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A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice

Sara S. Kornfeld-Sylla, Çiğdem Gelegen, Jordan E. Norris, Francesca A. Chaloner et autres

Pre-processed resting state EEG and LFP data from all mice (Figures 2-8 and supplementary figures 4-12).

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A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice

Sara S. Kornfeld-Sylla, Çiğdem Gelegen, Jordan E. Norris, Francesca A. Chaloner et autres

Pre-processed resting state EEG and LFP data from all mice (Figures 2-8 and supplementary figures 4-12).

gb (code pays fourni par la source)

FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions

Jae Citarella, Peyton Siekierski, Lauren E. Ethridge, Grace Westerkamp et autres

gene, is characterized by varying degrees of intellectual disability, autistic features, and sensory hypersensitivity. Despite phenotypic rescue in animal deletion models, clinical trials in humans have been unsuccessful, likely due to the heterogeneous nature of FXS. To uncover the basis of individual- …

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ROC Analysis of Biomarker Combinations in Fragile X Syndrome-Specific Clinical Trials: Evaluating Treatment Efficacy via Exploratory Biomarkers

Jordan E. Norris, Elizabeth Berry‐Kravis, Mark Harnett, Scott A. Reines et autres

Fragile X Syndrome (FXS) is a rare neurodevelopmental disorder caused by a trinucleotide repeat expansion on the 5' untranslated region of the FMR1 gene. FXS is characterized by intellectual disability, anxiety, sensory hypersensitivity, and difficulties with executive function. A recent phase 2 …

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Phenotypic variation in neural sensory processing by deletion size, age, and sex in Phelan-McDermid syndrome

Elizabeth Berry‐Kravis, Andrew Thaliath, Emily L. Isenstein, Allison Durkin et autres

BACKGROUND: Phelan-McDermid Syndrome (PMS) is a rare genetic condition characterized by deletion or mutation of region 22q13.3, which includes the SHANK3 gene. Clinical descriptions of this population include severely impaired or absent expressive language, mildly dysmorphic features, neonatal hypotonia, developmental delays, intellectual …

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