Salvatore Alfieri

Targeted Therapy-Induced Erythrocytosis in Thyroid Cancers: An Underrecognized Safety Signal from a Retrospective Study

Silvia Marchesi, Rebecca Romanò, Andrea Spagnoletti, Francesco Barretta et autres

Background: Antiangiogenic and targeted therapies represent the most effective systemic options for advanced thyroid cancers. In this setting, toxicity management is essential to ensure treatment adherence. Among hematological toxicities, erythrocytosis has been rarely investigated, and its clinical pattern and management remain unclear. …

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Liquid biopsies for BRAF V600E assessment and monitoring in anaplastic thyroid carcinoma: a real-world study of a tertiary cancer center

Elena Colombo, E. Ortolan, Stefano Cavalieri, Elena Tamborini et autres

BACKGROUND: Relapsed/metastatic anaplastic thyroid carcinoma (R/M ATC) is associated with poor prognosis. Approximately 40% of ATCs harbor the BRAFV600E mutation, for which targeted therapy is available. However, the clinical characteristics of BRAFV600E-mutant versus wild-type ATC and the role of liquid biopsy (LB) …

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Abstract 4897: Characterization of the intratumoral microbiota in non endemic EBV associated nasopharyngeal carcinoma

Deborah Lenoci, Federico Rossignoli, Armando G Licata, Marta Lucchetta et autres

Abstract Epstein-Barr virus (EBV) related nasopharyngeal carcinoma (NPC) is an epithelial malignancy arising from the nasopharyngeal mucosal lining. A high incidence of EBV related NPC is recorded in endemic areas (EA), East and Southeast Asia. Microbiota resides the upper respiratory tract including …

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Characterization of the Intratumoral Microbiota in Non-Endemic EBV-Related Nasopharyngeal Carcinoma

Deborah Lenoci, Federico Rossignoli, Armando G Licata, Marta Lucchetta et autres

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Adjuvant anti-PD-1 therapy in high-risk cutaneous squamous-cell carcinoma: post hoc insights from the C-POST and KEYNOTE-630 studies

Stefano Cavalieri, Arianna Ottini, Cristiana Bergamini, Salvatore Alfieri et autres

Background: Cutaneous squamous-cell carcinoma (cSCC) is cured with surgery with or without radiotherapy in most cases, but patients with high-risk features remain prone to recurrence. Until recently, no systemic adjuvant therapy was available. Recently, two phase III trials assessed post-operative anti-programmed cell …

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Lenvatinib in advanced thyroid, salivary gland, endometrial, and hepatocellular carcinomas: a real-world study on treatment duration and toxicity management

Elena Colombo, Monika Ducceschi, Stefano Cavalieri, Maggie Polignano et autres

Background: Lenvatinib (LEN) is a multikinase inhibitor used for different tumors: advanced differentiated thyroid cancers progressed or resistant to radioiodine (RAIR DTC), adenoid cystic carcinoma of salivary glands (AdCC), hepatocellular carcinoma (HCC), and endometrial carcinoma (EC). In the real-world setting, patients eligible …

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Systemic anticancer therapy during end of life in head and neck squamous cell carcinoma patients. A retrospective single center study.

Simone Rota, Silvia Buriolla, Andrea Franza, Stefano Cavalieri et autres

PURPOSE: Systemic anticancer treatments (SACTs) are used in advanced cancer stages to control disease and improve survival. However, their use at the end of life (Eol) can lead to side effects. This study aims to assess the clinical implications of SACTs near …

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The Multifaceted Role of Growth Differentiation Factor 15 (GDF15): A Narrative Review from Cancer Cachexia to Target Therapy

Daria Maria Filippini, Donatella Romaniello, Francesca Carosi, Laura Fabbri et autres

Background: Growth Differentiation Factor 15 (GDF15) has emerged as a key biomarker and therapeutic target in oncology, with roles extending beyond cancer cachexia. Elevated GDF15 levels correlate with poor prognosis across several solid tumors, including colorectal, gastric, pancreatic, breast, lung, prostate, and …

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Longitudinal assessment of plasma EBV-DNA in non-endemic EBV-related nasopharyngeal cancer (NPC): the LEA study

Salvatore Alfieri, Rebecca Romanò, Sara Marceglia, Carolina Sciortino et autres

BACKGROUND: Plasma Epstein Barr Virus (EBV)-DNA is an established biomarker for endemic EBV-related nasopharyngeal carcinoma (NPC). Its relevance in non-endemic regions is less understood. This study longitudinally assessed plasma EBV-DNA (LEA study) throughout the curative management of non-endemic EBV-related NPC to evaluate …

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The Role of Cetuximab in Non-Melanoma Skin Cancer: A Review of Clinical Evidence and Emerging Strategies

Imperia Nuzzolese, Stefano Cavalieri, Lisa Licitra, Salvatore Alfieri

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Radiochemotherapy for salivary gland adenoid cystic carcinoma: survival assessment through a retrospective study exploiting real-world data extracted from data warehouse

Stefano Cavalieri, Benedetta Lombardi Stocchetti, N. Crippa, Cecilia Silvestri et autres

Background and purpose Adenoid cystic carcinoma (ACC) is a rare salivary gland malignancy often characterized by an indolent course but significant risk of distant metastasis. The role of concurrent chemoradiotherapy (CRT) in improving oncologic outcomes remains controversial. This study aimed to assess …

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Mandibular swing approach: 25 years of experience at Istituto Nazionale Tumori of Milan

Marco Guzzo, Roberto Bianchi, Sarah Colombo, Filippo Santamato et autres

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