Imperia Nuzzolese

Risk of employment separation among workers with head and neck cancer: a longitudinal cohort study in Turin

Elena Farina, Lisa Licitra, Franco Mercalli, S Massari et autres

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Olfactory carcinoma: a distinct high-grade neuroepithelial carcinoma of the sinonasal tract

Stefano Cavalieri, M Moutafi, Margherita Piccinelli, Arianna Ottini et autres

BACKGROUND: Olfactory carcinoma (OC) is an emerging high-grade malignancy of the sinonasal tract with combined neuroepithelial and epithelial differentiation. Historically, tumors with these features were variably classified as olfactory neuroblastoma (ONB) with epithelial differentiation, mixed ONB-carcinoma, or high-grade neuroepithelial carcinoma. Increasing evidence …

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Targeted Therapy-Induced Erythrocytosis in Thyroid Cancers: An Underrecognized Safety Signal from a Retrospective Study

Silvia Marchesi, Rebecca Romanò, Andrea Spagnoletti, Francesco Barretta et autres

Background: Antiangiogenic and targeted therapies represent the most effective systemic options for advanced thyroid cancers. In this setting, toxicity management is essential to ensure treatment adherence. Among hematological toxicities, erythrocytosis has been rarely investigated, and its clinical pattern and management remain unclear. …

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Liquid biopsies for BRAF V600E assessment and monitoring in anaplastic thyroid carcinoma: a real-world study of a tertiary cancer center

Elena Colombo, E. Ortolan, Stefano Cavalieri, Elena Tamborini et autres

BACKGROUND: Relapsed/metastatic anaplastic thyroid carcinoma (R/M ATC) is associated with poor prognosis. Approximately 40% of ATCs harbor the BRAFV600E mutation, for which targeted therapy is available. However, the clinical characteristics of BRAFV600E-mutant versus wild-type ATC and the role of liquid biopsy (LB) …

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Representation of classical and rare head and neck cancers in basket clinical trials: A pooled analysis.

Elena Colombo, Markus Blaurock, Carolina de la Pinta, Anna La Salvia et autres

e18137 Background: Basket clinical trials (BCTs) aim to expand access to novel therapies across tumor types, including rare cancers. Head and neck cancers (HNC) comprise biologically heterogeneous entities with marked differences in incidence, etiology, and therapeutic sensitivity. How these factors influence specific …

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Subtype-specific representation of thyroid cancers in contemporary basket clinical trials (2018–2024): A pooled analysis.

Elena Colombo, Tiago Nunes da Silva, Carla Colombo, Anna La Salvia et autres

e18021 Background: Basket clinical trials (BCTs) are designed to overcome histology-based drug development by enrolling patients according to shared molecular alterations. A pooled analysis by Hazim and Prasad (2018) focused on biomarker (BM)-driven BCTs and reported an under-representation of thyroid cancers (TCs) …

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Secondary endpoint analysis of the BD4QoL randomized trial (NCT05315570): domain-specific quality of life changes in head and neck cancer survivors

Stefano Cavalieri, Chiara Airoldi, Antonello Manocchio, Luca M. Lacerenza et autres

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A tailored histology-driven molecular profiling algorithm proposal for salivary gland cancers

S. Alfieri, S. Rota, R. Romanò, Iolanda Capone et autres

BACKGROUND: Salivary gland cancers (SGCs) are rare, heterogeneous malignancies with limited systemic therapies. This study aimed to define a histology-driven molecular profiling (MP) algorithm for SGCs to optimize testing strategies and support therapeutic decision-making. MATERIALS AND METHODS: We retrospectively analyzed all SGC …

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LAT1 expression in head and neck cancer: a prognostic biomarker with potential relevance for BNCT

Stefano Cavalieri, Imperia Nuzzolese, Deborah Lenoci, Marta Lucchetta et autres

Purpose The increased expression of LAT1, an amino acid transporter, in cancer cells makes boronophenylalanine (BPA) uptake higher in cancer vs . healthy tissues: a high LAT1 expression on cancer cells implies a higher sensitivity to boron neutron capture therapy (BNCT). We …

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Adjuvant anti-PD-1 therapy in high-risk cutaneous squamous-cell carcinoma: post hoc insights from the C-POST and KEYNOTE-630 studies

Stefano Cavalieri, Arianna Ottini, Cristiana Bergamini, Salvatore Alfieri et autres

Background: Cutaneous squamous-cell carcinoma (cSCC) is cured with surgery with or without radiotherapy in most cases, but patients with high-risk features remain prone to recurrence. Until recently, no systemic adjuvant therapy was available. Recently, two phase III trials assessed post-operative anti-programmed cell …

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Impact of molecular tests and precision oncology on patients with advanced thyroid carcinomas in a referral center: the OrienTHYring real-world study

Elena Colombo, Stefano Cavalieri, A. Vingiani, Luca Agnelli et autres

BACKGROUND: Thyroid carcinomas (TCs) can harbor a variety of oncogenic drivers, but their prevalence according to the European Society of Medical Oncology (ESMO) Scale for Clinical Actionability of Molecular Targets (ESCAT) is unknown. Timing and modalities of molecular testing are not standardized, …

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Lenvatinib in advanced thyroid, salivary gland, endometrial, and hepatocellular carcinomas: a real-world study on treatment duration and toxicity management

Elena Colombo, Monika Ducceschi, Stefano Cavalieri, Maggie Polignano et autres

Background: Lenvatinib (LEN) is a multikinase inhibitor used for different tumors: advanced differentiated thyroid cancers progressed or resistant to radioiodine (RAIR DTC), adenoid cystic carcinoma of salivary glands (AdCC), hepatocellular carcinoma (HCC), and endometrial carcinoma (EC). In the real-world setting, patients eligible …

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