Matthew Kenwood

Shared transcriptomic signatures in perilesional and contralesional cortex after ischemic stroke

Dene Betz, Victoria Alers, Matthew Kenwood, Kielen R. Zuurbier et autres

Stroke induces a transient period of heightened plasticity during which functional recovery is most pronounced. Experimental models have identified repair-associated processes in both the ipsilesional and contralesional cortex, indicating that stroke recovery involves regions both remote and near the lesion. However, most …

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Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement

Julia Kaiser, Payal Patel, Sam Fedde, Alexander Lammers et autres

Skilled movement relies on descending cortical projections to the brainstem and spinal cord. The brainstem integrates cortical inputs from subcerebral projection neurons (SCPN). Here, we identify a previously unrecognized direct cortico-brainstem circuit that emerges early in development and persists into adulthood. A …

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Shared Transcriptomic Signatures in Perilesional and Contralesional Cortex

Dene Betz, Victoria Alers, Matthew Kenwood, Kielen R. Zuurbier et autres

Stroke induces a transient period of heightened plasticity during which functional recovery is most pronounced. Work in rodent models of stroke has identified key mechanisms in both the ipsilesional and contralesional cortex that contribute to functional and structural post-stroke plasticity. To date, …

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SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice

Katherine Poinsatte, Matthew Kenwood, Dene Betz, Ariana Nawaby et autres

The corticospinal tract (CST) is essential for forelimb-specific fine motor skills. In rodents, it undergoes extensive structural remodeling across development, injury, and disease states, with major implications for motor function. A vast body of literature, spanning numerous injury models, frequently assesses these …

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Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement

Vibhu Sahni, Julia Kaiser, Payal Patel, Svenja Fedde et autres

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SpinalTRAQ: A novel volumetric cervical spinal cord atlas identifies the corticospinal tract synaptic projectome in healthy and post-stroke mice

Katherine Poinsatte, Matthew Kenwood, Dene Betz, Ariana Nawaby et autres

Descending corticospinal tract (CST) connections to the neurons of the cervical spinal cord are vital for performance of forelimb-specific fine motor skills. In rodents, CST axons are almost entirely crossed at the level of the medullary decussation. While specific contralateral axon projections …

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Abstract TMP120: Contralesional Corticospinal Tract Reinnervates Cervical Spinal Anatomical Regions With Highest Pre-Lesion Synapse Density After Unilateral M1 Stroke in Mice

Matthew Kenwood, Katie Poinsatte, Aporva Ajay, Ariana Nawaby et autres

Introduction: Stroke leaves many patients with significant motor impairment. Following ischemic lesions of the rodent primary motor cortex, sprouting of the contralesional corticospinal tract (cCST) into the injured hemicord is associated with improved motor recovery. In adult mice, most corticospinal neurons project …

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Forage Species Identity Shapes Soil Biota in a Temperate Agroecosystem

Denise M. Finney, Samantha Garritano, Matthew Kenwood

Increasing plant diversity in the perennial phase of pasture-crop rotations is predicted to positively affect belowground productivity and microbial communities and, in turn, augment belowground agroecosystem services including soil health and carbon storage. Using two grass and one legume forage species grown …

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Getting to the ROOT of Climate Change: The Effects of Crop Diversity on Belowground Productivity

Matthew Kenwood

As atmospheric levels of carbon dioxide (CO2) continue to rise it is imperative to reduce greenhouse gas emissions from the major producers, including the intensive agricultural system responsible for growing food to feed the human population. The soil that has been farmed …

Nick Martin's Communism

Dylan Bagley, Matthew Kenwood

This project examines the life and career of Hungarian-born athlete Nick Martin. It explores the opportunities available to Martin via his success as an Olympic athlete.