HENRIK HERTZ

The ISL LIM‐homeobox 2 transcription factor is negatively regulated by circadian adrenergic signaling to repress the expression of Aanat in pinealocytes of the rat pineal gland

Kuno Michel-Jonathan Mattern, Aurea Susana Blancas‐Velazquez, Mikaella Ty Ngo, Signe Bille et autres

Melatonin is synthesized in the pineal gland during nighttime in response to nocturnal increase in the activity of the enzyme aralkylamine N-acetyltransferase (AANAT), the transcription of which is modulated by several homeodomain transcription factors. Recent work suggests that the homeodomain transcription factor …

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The Circadian Oscillator of the Cerebellum: Triiodothyronine Regulates Clock Gene Expression in Granule Cells in vitro and in the Cerebellum of Neonatal Rats in vivo

Tenna Bering, HENRIK HERTZ, Martin F. Rath

The central circadian clock resides in the suprachiasmatic nucleus (SCN) of the hypothalamus, but an SCN-dependent molecular circadian oscillator is present in the cerebellar cortex. Recent findings suggest that circadian release of corticosterone is capable of driving the circadian oscillator of the …

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The role of homeobox gene‐encoded transcription factors in regulation of phototransduction: Implementing the primary pinealocyte culture as a photoreceptor model

HENRIK HERTZ, Aurea Susana Blancas‐Velazquez, Martin F. Rath

Homeobox genes encode transcription factors controlling development; however, a number of homeobox genes are expressed postnatally specifically in melatonin-producing pinealocytes of the pineal gland and photoreceptors of the retina along with transcripts devoted to melatonin synthesis and phototransduction. Homeobox genes regulate melatonin …

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Neurotrophic Effects of Vascular Endothelial Growth Factor B and Novel Mimetic Peptides on Neurons from the Central Nervous System

Oksana Dmytriyeva, Amaia de Diego Ajenjo, Kathrine Lundø, HENRIK HERTZ et autres

Vascular endothelial growth factor B (VEGFB) is a pleiotropic trophic factor, which in contrast to the closely related VEGFA is known to have a limited effect on angiogenesis. VEGFB improves survival in various tissues including the nervous system, where the effect was …

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Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland

Mikkel Bloss Carstensen, HENRIK HERTZ, Tenna Bering, Morten Møller et autres

The pineal gland is a neuroendocrine organ responsible for production of the nocturnal hormone melatonin. A specific set of homeobox gene-encoded transcription factors govern pineal development, and some are expressed in adulthood. The brain-specific homeobox gene (Bsx) falls into both categories. We …

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The Lhx4 homeobox transcript in the rat pineal gland: Adrenergic regulation and impact on transcripts encoding melatonin‐synthesizing enzymes

HENRIK HERTZ, Mikkel Bloss Carstensen, Tenna Bering, Kristian Rohde et autres

Homeobox genes generally encode transcription factors involved in regulating developmental processes. In the pineal gland, a brain structure devoted to nocturnal melatonin synthesis, a number of homeobox genes are also expressed postnatally; among these is the LIM homeobox 4 gene (Lhx4). We …

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Rhythmic Release of Corticosterone Induces Circadian Clock Gene Expression in the Cerebellum

Tenna Bering, HENRIK HERTZ, Martin F. Rath

Neurons of the cerebellar cortex contain a circadian oscillator, with circadian expression of clock genes being controlled by the master clock of the suprachiasmatic nucleus (SCN). However, the signaling pathway connecting the SCN to the cerebellum is unknown. Glucocorticoids exhibit a prominent …

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Homeobox genes in melatonin‐producing pinealocytes: Otx2 and Crx act to promote hormone synthesis in the mature rat pineal gland

Kristian Rohde, HENRIK HERTZ, Martin F. Rath

Homeobox genes encode transcription factors that regulate developmental processes; however, in the pineal gland, a neuroendocrine organ responsible for nocturnal melatonin synthesis, expression of the homeobox genes Otx2 (orthodenticle homeobox 2) and Crx (cone-rod homeobox) persists postnatally. We here show that OTX2 …

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Supplementary Material for: Rhythmic Release of Corticosterone Induces Circadian Clock Gene Expression in the Cerebellum

Tatiana Bering, HENRIK HERTZ, Martin F. Rath

Neurons of the cerebellar cortex contain a circadian oscillator, with circadian expression of clock genes being controlled by the master clock of the suprachiasmatic nucleus (SCN). However, the signaling pathway connecting the SCN to the cerebellum is unknown. Glucocorticoids exhibit a prominent …

Børneafdelingen. Syge børn og børnesygdomme på Rigshospitalet 1910-2010

Anne Katrine Kleberg Hansen, HENRIK HERTZ, Anne Løkke

En undersøgelse af udviklingen i sygdomspanoramaet, behandlingerne og børneopfattelsen 1910-2010 ved Rigshospitalets børneafdeling.

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PROTEIN STUDIES ON CEREBROSPINAL FLUID AND NEUROLOGICAL SYMPTOMS IN MYELOMATOSIS

Esther Frantzen, HENRIK HERTZ, Jørgen Matzke, Aa. Videbæk

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Development of the Seminiferous Epithelium During and After Treatment for Acute Lymphoblastic Leukemia in Childhood

J oslash rn M uuml ller, HENRIK HERTZ, Niels E. Skakkebœk

Research Articles| December 02 2008 Development of the Seminiferous Epithelium During and After Treatment for Acute Lymphoblastic Leukemia in Childhood Subject Area: Endocrinology , Women's and Children's Health Jørn Müller; Jørn Müller aLaboratory of Reproductive Biology, University Department of Obstetrics and Gynecology …

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