Local Delivery of Non-opioid Analgesic Microparticles to Modulate Post-surgical Pain
P. Murali Mohan, Jeladhara Sobhanan, Caitlyn M. Gaffney, Nitisha Mehrotra et autres
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P. Murali Mohan, Jeladhara Sobhanan, Caitlyn M. Gaffney, Nitisha Mehrotra et autres
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Nitisha Mehrotra, Aparna Adumbumkulath, Paul Kim, Suran Somawardana et autres
Background: Small diameter (<6mm) arterial reconstruction often requires the use of autologous and synthetic vascular substitutes. While autologous conduits are the gold standard, because of their limited availability synthetic conduits are often used. However, synthetic conduits can lead to poor outcomes due …
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Nitisha Mehrotra, Aparna Adumbumkulath, Paul Kim, Suran Somawardana et autres
Small diameter (<6 mm) arterial reconstruction often requires the use of autologous and synthetic vascular substitutes. Although autologous conduits are the gold standard, because of their limited availability, synthetic conduits are often used. However, synthetic conduits can lead to poor outcomes due …
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Aparna Adumbumkulath, Crystal S. Shin, Ghanashyam S. Acharya, Jayer Chung et autres
Background: Diabetic foot ulcerations (DFUs) become non-healing wounds once they stall in the chronic inflammatory phase (CIP), making it vulnerable to infection. Dysregulated secretion of pro-inflammatory cytokines and matrix metalloproteinase (MMPs) are responsible for DFUs that remain in the CIP. Limitations for …
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Advances in materials engineering have led to the development of several biomaterials for surgical implants, catheters, sutures, grafts, and drug delivery systems. However, most of the currently available biomaterials are immunogenic and fibrogenic with compliance mismatch with the host tissue and often …
Soumyabrata Roy, Firuz Alam Philip, Eliezer Fernando Oliveira, Gurwinder Singh et autres
With increasing global climate change, integrated concepts to innovate sustainable structures that can multiaxially address CO2 mitigation are crucial. Here, we fabricate a functional wood structure with enhanced mechanical performance via a top-down approach incorporating a high-performance metal-organic framework (MOF), Calgary framework …
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Crystal S. Shin, Remya Ammassam Veettil, Tamil Selvan Sakthivel, Aparna Adumbumkulath et autres
Diseases affecting the retina, such as age-related macular degeneration (AMD), diabetic retinopathy, macular edema, and retinal vein occlusions, are currently treated by the intravitreal injection of drug formulations. These disease pathologies are driven by oxidative damage due to chronic high concentrations of …
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Remya Ammassam Veettil, Daniela C. Marcano, Xiaoyong Yuan, Mahira Zaheer et autres
Eye injuries due to corneal abrasions, chemical spills, penetrating wounds, and microbial infections cause corneal scarring and opacification that result in impaired vision or blindness. However, presently available eye drop formulations of anti-inflammatory and antibiotic drugs are not effective due to their …
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Soumyabrata Roy, Xiang Zhang, Anand B. Puthirath, Meiyazhagan Ashokkumar et autres
Hexagonal boron nitride (h-BN) has emerged as a strong candidate for two-dimensional (2D) material owing to its exciting optoelectrical properties combined with mechanical robustness, thermal stability, and chemical inertness. Super-thin h-BN layers have gained significant attention from the scientific community for many …
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Aparna Adumbumkulath, Crystal S. Shin, Ghanashyam S. Acharya, Papiya Biswas et autres
MgAl 2 O 4 spinel mesh with micro-features of 410 and 250 μm unit cell length and rib thickness, respectively, was three-dimensional (3D) printed and sintered followed by Hot Isostatic Pressing (HIPing). A stable colloidal dispersion of spinel in polymer-water solution was …
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Crystal S. Shin, Fernando J. Cabrera, Richard Lee, John Kim et autres
Development of inflammation modulating polymer scaffolds for soft tissue repair with minimal postsurgical complications is a compelling clinical need. However, the current standard of care soft tissue repair meshes for hernia repair is highly inflammatory and initiates a dysregulated inflammatory process causing …
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Seohui Jung, Yufei Cui, Morgan G. Barnes, Chinmay C. Satam et autres
In article 1908291, Muhammad M. Rahman, Pulickel M. Ajayan, and co-workers present a conformal bio-nanocomposite coating based on cellulose nanocrystals and poly(albumen) that increases the shelf-life of fresh produce by retarding ripening, dehydration, and microbial attack. The coating is edible, easily washable, …
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