3D‐Bioprinted Inflammation Modulating Polymer Scaffolds for Soft Tissue Repair
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Le résumé fourni par la source
Development of inflammation modulating polymer scaffolds for soft tissue repair with minimal postsurgical complications is a compelling clinical need. However, the current standard of care soft tissue repair meshes for hernia repair is highly inflammatory and initiates a dysregulated inflammatory process causing visceral adhesions and postsurgical complications. Herein, the development of an inflammation modulating biomaterial scaffold (bioscaffold) for soft tissue repair is presented. The bioscaffold design is based on the idea that, if the excess proinflammatory cytokines are sequestered from the site of injury by the surgical implantation of a bioscaffold, the inflammatory response can be modulated, and the visceral adhesion formations and postsurgical complications can be minimized. The bioscaffold is fabricated by 3D-bioprinting of an in situ phosphate crosslinked poly(vinyl alcohol) polymer. In vivo efficacy of the bioscaffold is evaluated in a rat ventral hernia model. In vivo proinflammatory cytokine expression analysis and histopathological analysis of the tissues have confirmed that the bioscaffold acts as an inflammation trap and captures the proinflammatory cytokines secreted at the implant site and effectively modulates the local inflammation without the need for exogenous anti-inflammatory agents. The bioscaffold is very effective in inhibiting visceral adhesions formation and minimizing postsurgical complications.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- 3D‐Bioprinted Inflammation Modulating Polymer Scaffolds for Soft Tissue Repair
- Date Crossref
- 16/12/2020
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Michael E. DeBakey VA Medical Center pays non établi dans la noticeÉtablissement de santé
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Baylor College of Medicine Michael E. DeBakey Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Rice University Department of Materials Science and Nanoengineering pays non établi dans la noticeUniversité ou école supérieure
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Christus Health pays non établi dans la noticeÉtablissement de santé
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Oncology Institute pays non établi dans la noticeStructure de recherche
Michael E. DeBakey VA Medical Center, Michael E. DeBakey Department of Surgery — Baylor College of Medicine et Department of Materials Science and Nanoengineering — Rice University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.