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2026
article
OpenAlex
Antonios Gkantaras, ESID Registry Working Party, Dalia Abd Elaziz, Sohilla Lofty M. Abdelkader et autres
Diagnosing common variable immunodeficiency (CVID) in childhood remains contentious, as monogenic inborn errors of immunity (IEIs) are increasingly recognized in CVID-like phenotypes. We analyzed 7,525 ESID Registry patients with a clinical diagnosis of CVID to investigate age-dependent genetic architecture and associated phenotypes. …
gr
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2026
article
OpenAlex
José Pedro Cidade, Fabio Silvio Taccone, Luis Felipe Reyes, Laura Merson et autres
OBJECTIVE: Immune dysregulation plays a pivotal role in the pathophysiology of sepsis and COVID-19, with lymphopenia emerging as a consistent marker of severity and poor prognosis. However, most existing studies have assessed lymphocyte counts at isolated time points, limiting insights into their …
pt, gb, be, co, fr, id, dk, us
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2025
article
OpenAlex
Gerhard Kindle, Mickaël Alligon, Michael H. Albert, Matthew Buckland et autres
The European Society for Immunodeficiencies patient registry (ESID-R), established in 1994, is one of the world's largest databases on inborn errors of immunity (IEI). IEI are genetic disorders predisposing patients to infections, autoimmunity, inflammation, allergies, and malignancies. Treatments include antimicrobial therapy, immunoglobulin …
de, fr, gb, ca, ie, gr, it, us, by, ch, il, be, se
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2025
article
OpenAlex
Elise Pesonel, Cédric Laouénan, Laetitia Guiraud, Josephine Bourner et autres
BACKGROUND: The global mpox outbreak that started in May 2022 was caused by a novel clade IIb variant of the mpox virus (Orthopoxvirus monkeypox, MPXV). It differed from the traditional Western and Central Africa disease in transmission patterns and clinical presentation. METHODS: …
gb, fr, ch, us, no, it, be, es, vn
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2024
article
OpenAlex
Muskan Israni, Eliška Alderson, Nizar Mahlaoui, Laura Obici et autres
PURPOSE: Significant improvements in the prognosis for young patients with Primary Immunodeficiency Diseases (PID) and Autoinflammatory Disorders (AID), which together make up the majority of Inborn Errors of Immunity (IEI), have resulted in the need for optimisation of transition and transfer of …
gb, fr, it, si, nl, de, es, se
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Accès ouvert
2024
article
OpenAlex
Arnaud Bruyneel, Jérôme E. Dauvergne, Nicolás Dauby, Jean‐Christophe Goffard et autres
Introduction The literature establishes a clear social gradient in health for transmissible respiratory diseases. However, this gradient’s extent remains largely unexplored in the context of COVID-19, and it is uncertain whether the pandemic has exacerbated this gradient. The study aims to compare …
be, fr
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2024
article
OpenAlex
Jérémie Rosain, Tom Le Voyer, Xian Liu, Adrian Gervais et autres
Human inborn errors of thymic T cell tolerance underlie the production of autoantibodies (auto-Abs) neutralizing type I IFNs, which predispose to severe viral diseases. We analyze 131 female patients with X-linked dominant incontinentia pigmenti (IP), heterozygous for loss-of-function (LOF) NEMO variants, from …
fr, ca, us, se, gb, it, rs, Somalie, ag, jp, de, nl, ch, qa, tw, be
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2024
article
OpenAlex
An Vercoutere, Judith Racapé, Mbiton Joel M.J. Zina, Sophie Alexander et autres
Background: Pregnant women are more vulnerable to the severe effects of COVID-19 compared to their non-pregnant peers. Early in the pandemic, there was a rise in cesarean deliveries and preterm births among infected pregnant women. This study aims to evaluate whether there …
be, ch
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2024
article
OpenAlex
Munib Mesinovic, Xin Ci Wong, Giri Shan Rajahram, Barbara Wanjiru Citarella et autres
By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to …
gb, kr, my, nl, sa, jp, fr, be, us, de, it, pt, ie, th, qa, kw, es, gi, ca, br, bd, cl, Afrique du Sud, la
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2024
article
OpenAlex
An Vercoutere, Mbiton Joel M.J. Zina, Meltem Telis, Jean‐Christophe Goffard et autres
PURPOSE: Pregnant women are at risk of severe SARS-CoV-2 infection, potentially leading to obstetric and neonatal complications. Placental transfer of antibodies directed to SARS-CoV-2 may be protective against neonatal COVID-19, but this remains to be studied. We aimed to determine the seroprevalence …
be
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Accès ouvert
2024
article
OpenAlex
Barbara Wanjiru Citarella, Elsa D. Ibáñez-Prada, Bronner P. Gonçalves, Martina Escher et autres
Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms …
in, gb, co, lu, ca, nl, pt, ie, jp, id, es, fr, au
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Accès ouvert
2024
article
OpenAlex
Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos et autres
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of …
fr, us, gb, au, nl, ch
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