Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients

José Pedro Cidade, Fabio Silvio Taccone, Luis Felipe Reyes, Laura Merson, Benjamin Lefevre, Barbara Wanjiru Citarella, Arie Zainul Fatoni, Pedro Póvoa, the ISARIC Characterization Group, Sabriya Abdalasalam, Alaa Abdalfattah Abdalhadi, Naana Reyam Abdalla, Almthani Hamza Abdalrheem, Saedah Abdeewi, Esraa Hassan Abdelgaum, Mohamed Abdelhalim, Mohammed Abdelkabir, Sheryl Ann Abdukahil, Lamees Adil Abdulbaqi, Nurul Najmee Abdulkadir, Eman Abdulwahed, Rawad Abdunabi, Ryuzo Abe, Laurent Abel, Ahmed Mohammed Abodina, Amal Abrous, Kamal Abu Jabal, Nashat Abu Salah, Abdurraouf Abusalama, Subhash Acharya, Andrew Acker, Safia Adem, Manuella Ademnou, Neill K. J. Adhikari, Samuel Yaw Adu, Anthony Afum-Adjei Awuah, Melvin Agbogbatey, Saleh Al Ageel, Musaab Mohammed Ahmed, Aya Mustafa Ahmed, Zainab Ahmed Alaraji, Abdulrahman Ahmed Elhefnawy Enan, R Khalil, Ali Abdelaziz, Kate Ainscough, Eka Airlangga, Tharwat Aisa, Ali Ait Hssain, Takako Akimoto, Ernita Akmal, Chika Akwani, Eman Al Qasim, Ahmed Alajeeli, Razi Alalqam, Zinah A. Alaraji, Safa Albatni, Angela Alberti, Tala Al-dabbous, Abdulkarim Aldoukali, Marta Alessi, Beatrice Alex, Kévin Alexandre, Abdulrahman Al-Fares, Asil Omar Saleh Alflite, Huda Alfoudri, Qamrah Alhadad, Hoda Salem Alhaddad, Maali Khalid Mohamed Abdalla Alhasan, Hasan Alhouri, Ahmad Nabil Alhouri, Maha TagElser Mohammed Ali, Imran Ali, Yomna Ali Abdelghafar, Kazali Enagnon Alidjnou, Mahmoud Aljadi, Sarah Aljamal, Mohammed Alkahlout, Akram Alkaseek, Qabas Alkhafajee, Clotilde Allavena, Nathalie Allou, Abdulrahman Almjersah, Walaa Alrfaea, Moayad Alrifaee, Yousef Al-Sabaa, Entisar Alshareea, João Melo Alves, Rita Vieira Alves, Joana Alves Cabrita, Maria Amaral, Amro Essam Amer, Nur Amira, Heidi Ammerlaan, Amos Amoako Adusei, John Amuasi, Roberto Andini, Claire Andrejak, Andrea Angheben, François Angoulvant, SÉVERINE ANSART, Massimo Antonelli, Ardiyan Apriyana, Yaseen Arabi, Irene Aragao, Francisco Arancibia, Antonio Arcadipane, Patrick Archambault, Lukas Arenz, Jean‐Benoît Arlet, Christel Arnold-Day, Lovkesh Arora, Elise Artaud-Macari, Diptesh Aryal, Motohiro Asaki, Angel Asensio, Elizabeth A. Ashley, Muhammad Sheharyar Ashraf, Abir Ben Ashur, Franklin Asiedu‐Bekoe, Namra Asif, Mohammad Asim, Grace Assi, Jean Baptiste Assie, Amirul Asyraf, Ahmed Atia, Minahel Atif, Asia Atif Abdelrhman Abdallahrs, Anika Atique, Moad Atlowly, Johann Auchabie, Hugues Aumaitre, Adrien Auvet, A.M. Ayad, Ahmed Helmi, Laurène Azemar, Mohammed G. Azizeldin, Cécile Azoulay, Benjamin Bach, Antoine Bachelard, Delphine Bachelet, John Kenneth Baillie, J. Kevin Baird, Erica Bak, Agamemnon Bakakos, Nazreen Abu Bakar, Hibah Bileid Bakeer, Ashraf Bakri, Andriy Bal, Mohanaprasanth Balakrishnan, Alessandra Bandera, Firouzé Bani-Sadr, Nicholas Yuri Barbosa, Wendy S. Barclay, Saef Umar Barnett, Michaela Barnikel, Cleide Barrigoto, Marie Bartoli, Cheryl Bartone, Joaquín Baruch, Romain Basmaci, Muhammad Fadhli Hassin Basri, AbdAlkarim Batool, Denise Battaglini, Jules Bauer, Diego Fernando Bautista Rincón, Alexandra Bedossa, Ker Hong Bee, Husna Begum, Aleksandr Beljantsev, Beatriz Amorim Beltrão, Marine Beluze, Nicolas Benech, Lionel Eric Benjiman, Suzanne Bennett, Luís Bento, Jan‐Erik Berdal, Delphine Bergeaud, José Luis Bernal Sobrino, Giulia Bertoli, Lorenzo Bertolino, Simon Bessis, Adam Betz, Sybille Bevilcaqua, Karine Bezulier, Amar Bhatt, Claudia Bianco, Sandra Bichoka, Farah Nadiah Bidin, Felwa Bin Humaid, Mohd Nazlin Bin Kamarudin, Muhannud Binnawara, Patrick Biston, Laurent Bitker, Pablo Blanco-Schweizer, Catherine Blier, Frank Bloos, Mathieu Blot, Filomena Boccia, Laetitia Bodénes, Debby Bogaert, Anne-Hélène Boivin, Ariel Bolanga, Isabela Bolaños, Pierre-Adrien Bolze, Aurelius Bonifasius, Joseph Bonney, Diogo Borges, Raphaël Borie, Elisabeth Botelho-Nevers, Lila Bouadma, Yasmine Bouaraba, Olivier Bouchaud, Sabelline Bouchez, Kévin Bouiller, Laurence Bouillet, Camile Bouisse, Latsaniphone Bountthasavong, Anne‐Sophie Boureau, John Bourke, Maude Bouscambert, Aurore Bousquet, Marielle Boyer-Besseyre, Maria Boylan, Fernando Augusto Bozza, Axelle Braconnier, Luca Brazzi, Patrick Breen, David Brewster, Kathy Brickell, Tessa Broadley, Petra Bryda, Nina Buchtele, Polina Bugaeva, Marielle Buisson, Erlina Burhan, Donald Buri, Aidan Burrell, Ingrid G. Bustos, Denis Butnaru, André Cabié, Susana Cabral, Eder Cáceres, Cyril Cadoz, Rui Caetano Garcês, Mia Callahan, Jose Andres Calvache, João Camões, Paul Campbell, Josie Campisi, Cecilia Canepa, Mireia Cantero, Janice Caoili, Pauline Caraux-Paz, Filipa Cardoso, Sofia Cardoso, Nelson Cardoso, Filipe Cardoso, Simone Carelli, Nicolas Carlier, Thierry Carmoi, Gayle Carney, Inês Carqueja, Marie-Christine Carret, François Martin Carrier, Ida Carroll, Leonor Carvalho, Maire-Laure Casanova, Mariana Cascão, Siobhan Casey, José Casimiro, Bailey Cassandra, Silvia Castañeda, Guylaine Castor-Alexandre, Ana Catarino, François-Xavier Catherine, Roberto Cauda, Giulio- Giovanni Cavalli, Alexandros Cavayas, Adrián Ceccato, Ferruccio Ceriotti, Shelby Cerkovnik, Minerva Cervantes, Minerva Cervantes-Gonzalez, Müge Çevik, Anissa Chair, Catherine Chakveatze, Roberto Chalela, Adrienne Chan, Meera Chand, Jean-Marc Chapplain, Charlotte Charpentier, Julie Chas, Muhammad -Mobin Chaudry, Jonathan Samuel Chávez Iñiguez, Anjellica Chen, Matthew Pellan Cheng, Antoine Cheret, Thibault Chiarabini, Julián Chica, Suresh-Kumar Chidambaram, Leong Chin Tho, Catherine Chirouze, Hwa Jin Cho, Danoy Chommanam, Marie‐Charlotte Chopin, Ting Soo Chow, Nathaniel Christy, Hiu Jian Chua, Jonathan Chua, José Miguel Cisneros Herreros, Anna Ciullo, Jennifer Clarke, Rolando Claure-Del Granado, Sara Clohisey, Peter David Coakley, Caitriona Cody, Megan Coles, Jennifer Coles, Gwenhaël Colin, Michael Collins, Pamela Combs, Jennifer Connolly, Marie Connor, Anne Conrad, Elaine Conway, Graham S. Cooke, H. Cordel, Amanda Corley, Sabine Cornelis, Arianne Joy Corpuz, Andrea Cortegiani, Grégory Corvaisier, Aoife Cotter, Sandrine Couffin-Cadiergues, Roxane Courtois, Stéphanie Cousse, Juthaporn Cowan, Rachel Cregan, Charles Crepy D Orleans, Cosimo Cristella, Gloria Crowl, Jonathan Crump, Claudina Cruz, Juan Luis Cruz Bermúdez, Jaime Cruz‐Rojo, Marc Csete, Ailbhe Cullen, Matthew Cummings, Gerard Curley, Elodie Curlier, Colleen Curran, Ana da Silva Filipe, Charlène Da Silveira, Al-Awwab Dabaliz, Andrew Dagens, Darren Dahly, Peter Daley, Zaina Dalloul, J. Dalton, Heidi Dalton, Seamus Daly, Juliana Damas, Joycelyn Assimeng Dame, Cammandji Damien, Nick Daneman, Jorge Dantas, Menno de Jong, Fernando De La Calle Prieto, Gillian de Loughry, Diego de Mendoza, Étienne de Montmollin, Ana Isabel de Pinho Oliveira, Rosanna de Rosa, Thushan de Silva, Peter de Vries, Alexa Debard, Bianca DeBenedictis, Marie-Pierre Debray, Nathalie DeCastro, William Dechert, Romain Decours, Eve Defous, Isabelle Delacroix, Alexandre Délamou, K. Delavigne, Nathalie M. Delfos, Andrea Dell Amore, Christelle Delmas, Pierre Delobel, Ismaila Deme, Elisa Demonchy, Emmanuelle Denis, Dominique Deplanque, Pieter Depuydt, Diane Descamps, Mathilde Desvallées, Santi Dewayanti, Pathik Dhangar, Alpha Diallo, Souleymane Diallo, Sylvain Diamantis, Andrea Dias, André Dias, Juan José Díaz, Priscila Diaz, Rodrigo Diaz, Kévin Didier, Jean-Luc Diehl, Aurélien Dinh, Alphonsine Diouf, Yael Dishon, Cedric Djadda, Félix Djossou, Nikita Dobremel, Annemarie B. Docherty, Helen Doherty, Arjen M. Dondorp, Christl A. Donnelly, Yoann Donohue, Sean Donohue, Peter Doran, Céline Dorival, Eric D Ortenzio, Phouvieng Douangdala, James Joshua Douglas, Nathalie Dournon, Thomas Drake, Aoife Driscoll, Ibrahim Kwaku Duah, Vincent Dubee, François Dubos, Audrey Dubot‐Pérès, Alexandre Ducancelle, Susanne Dudman, Abhijit Duggal, Paul Dunand, Jake Dunning, Mathilde Duplaix, Emanuele Durante-Mangoni, Lucian Durham, B. Dussol, Xavier Duval, Anne Margarita Dyrhol-Riise, Sim-Choon Ean, Marco Echeverria-Villalobos, Michael Edelstein, Khadeja Ehzaz, Carla Eira, Mohammed El Sanharawi, Subbarao Elapavaluru, Mohammad Elbahnasawy, Brigitte Elharrar, Hamida ELMagrahi, Lauren Eloundou, Philippine Eloy, Tarek Elshazly, Wafa Elsokni, A Eltayeb, Iqbal Elyazar, Zarief Kamel Emad, Hussein Embarek, Isabelle Enderle, Tomoyuki Endo, Gervais Eneli, Chan Chee Eng, Ilka Engelmann, Vincent Enouf, Olivier Épaulard, Haneen Esaadi, Mariano Esperatti, Catarina Espírito Santo, Marina Esposito-Farese, Rachel Essaka, João Estevão, Manuel Etienne, Anna Greti Everding, Mirjam E. J. W. Evers, Marc Fabre, Isabelle Fabre, Asgad Osman Abdalla Fadlalla, Amna Faheem, Arabella Fahy, Cameron J. Fairfield, Komal Fareed, Pedro Faria, Ahmed Farooq, Hanan Fateena, Salem Fatima, Karine Faure, Raphaël Favory, Mohamed Fayed, Niamh Feely, Eoin Feeney, S. M. L. 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Joseph, Mark Joseph, Evelyn S. Joson, Mercé Jourdain, Philippe Jouvet, Anna Jung, Dafsah Arifa Juzar, Ouifiya Kafif, Florentia Kaguelidou, Neerusha Kaisbain, Sabrina Kali, Smaragdi Kalomoiri, Muhammad Aisar Ayadi Kamaluddin, Armand Saloun Kamano, Zul Amali Che Kamaruddin, Nadiah Kamarudin, Darshana Hewa Kandamby, Kong Yeow Kang, Dyah Kanyawati, Mohamed Karghul, Pratap Karpayah, Christiana Kartsonaki, Daisuke Kasugai, Kevin Katz, Christy Kay, Lamees Kayyali, Seán Keating, Aoife Kelly, Niamh Kelly, Sadie Kelly, Yvelynne Kelly, Maeve Kelsey, Sommay Keomany, Maeve Kernan, Younes Kerroumi, Keshav Sharma, Shams Khail, Sarah Khaled, Imrana Khalid, Zineb Khalil, Antoine Khalil, Irfan Khan, Sushil Khanal, Michelle E. Kho, Denisa Khoo, Saye Khoo, Ryan Khoo, Muhammad Nasir Khoso, Khor How Kiat, Yuri Kida, Peter Kiiza, Beathe Kiland Granerud, Anders Benjamin Kildal, Jae Burm Kim, Antoine Kimmoun, Paul Klenerman, Gry Kloumann Bekken, Stephen R. Knight, Robin Kobbe, Chamira Kodippily, Sabin Koirala, Stephanie Kouba, Karifa Kourouma, Mohamed Lamine Kourouma, Karolina Krawczyk, A Kredan, Vinothini Krishnan, Sudhir Krishnan, Oksana Kruglova, Anneli Krund, Pei Xuan Kuan, Ganesh Kumar, Deepali Kumar, Dinesh Kuriakose, Ethan Kurtzman, Demetrios Kutsogiannis, Galyna A Kutsyna, Sylvie Kwedi, Konstantinos Kyriakoulis, Marie Lachatre, Karine Lacombe, Marie Lacoste, John G. 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Moore, Lina Morales Cely, Marwa Morgom, Lucia Moro, Ana Belén Sánchez Motos, Clara Mouton Perrot, Julien Moyet, Suleiman Haitham Mualla, Aisha Kalsoom Mufti, Ng Yong Muh, Mo nes Muhaisen, Dzawani Muhamad, Jimmy Mullaert, Karl Erik Müller, Fredrik Müller, Daniel Munblit, Syed Muneeb Ali, Laveena Munshi, Aisling Murphy, Patrick Murray, Marlène Murris, Srinivas Murthy, Himed Musaab, Dana Mustafa, Dimitra Melia Myrodia, Farah Nadia Mohd-Hanafiah, Dave Nagpal, Blanka Nagybányai-Nagy, Herwin Nanda Boudoin, Mangala Narasimhan, Adel Gerges Nassif Metri, Nadège Neant, Coca Necsoi, Nikita Nekliudov, Matthew Nelder, Erni Juwita Nelwan, Emily Neumann, Wing Yiu Ng, Pauline Yeung Ng, Anthony Nghi, Duc Nguyen, Orna Ni Choileain, Niamh Ni Leathlobhair, Nerissa Niba, Alistair D. Nichol, Nurul Amani Mohd Noordin, Nurul Faten Izzati Norharizam, Mahdad Noursadeghi, Adam Nowinski, Saad Nseir, Leonard Numfor, Nurnaningsih Nurnaningsih, Dwi Utomo Nusantara, Elsa Nyamankolly, Fionnuala O. Brien, Annmarie O. 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Robertson, Olivier Robineau, Ferran Roche-Campo, Paola Rodari, Simão Rodeia, Bernhard Roessler, Claire Roger, Amanda Rojek, Roberto Roncon-Albuquerque, M. Roriz, Manuel Rosa-Calatrava, Michael Rose, Dorothea Rosenberger, Andrea Rossanese, Matteo Rossetti, Patrick Rossignol, Carine Roy, Benoît Roze, Desy Rusmawatiningtyas, Clark D. Russell, Maeve Ryan, Aleksander Rygh Holten, Isabela Saba, Sairah Sadaf, Musharaf Sadat, Valla Sahraei, Abdurraouf Said, Fodé Bangaly Sako, Moamen Salah, Ali Alaa Salah Eldin Mohamed Abbas, Nawal Salahuddin, Leonardo Salazar, Mohammed Saleh Alyasiri, Gabriele Sales, Charlotte Salmon Gandonniere, Hélène Salvator, Yehia Samir Shaaban Aly Orabi, Olivier Sanchez, Emely Vásquez Sánchez, Angel Sanchez-Miralles, Gyan Sandhu, Zulfiqar Sandhu, Pierre-François Sandrine, Oana Săndulescu, Marlene Santos, Lurdes Santos, Shirley Sarfo-Mensah, Bruno Sarmento Banheiro, Benjamine Sarton, Sree Satyapriya, Rumaisah Satyawati, Yen Tsen Saw, Justin Schäffer, Tjard Schermer, Arnaud Scherpereel, Marion Schneider, János Schnur, Michael Schwameis, Gary Schwartz, J. Scott, Nicholas Sedillot, Tamara Cortés Seitz, Mageswari Selvarajoo, Malcolm G. Semple, Rasidah B. T. 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