Aleksandra Beric

Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer Disease

Julie K. Wisch, Ziqiao Jiao, Peter R Millar, Nicole Sarah McKay et autres

Objective: Disease progression modeling (DPM) or "amyloid time" is increasingly used to stage Alzheimer disease (AD). DPM performance depends on within-individual heterogeneity in rates of pathological accumulation as well as test-retest reliability of the biomarker. The relative contributions of these variabilities have …

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Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer’s Disease

Wenjing Lin, Aleksandra Beric, Julie K. Wisch, Bryce Baker et autres

ABSTRACT BACKGROUND Increasing evidence suggests that accurate prediction of Alzheimer’s disease (AD) symptom onset requires more than amyloid- and tau-centric biomarkers such as cerebrospinal fluid (CSF) Aβ42/40, total tau and p-tau181 and plasma p-tau217. Autosomal dominant AD (ADAD), caused by pathogenic PSEN1, …

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Understanding Neurodegenerative Diseases From the −Omics Perspective: Lessons Learnt

Laura Ibanez, Cyril P. Pottier, Aleksandra Beric, Daniel Western et autres

As the population ages, certain neurodegenerative diseases (NDs) are becoming a major health issue. For this reason, this review will focus on the most common ND with onset after 65 years old; Alzheimer's disease, Parkinson's disease, Lewy body dementia, and frontotemporal dementia. …

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Study of blood linear RNA nominates CD55 and DLD as early-stage biomarkers for Parkinson's disease

Aleksandra Beric, Sarp Sahin, Santiago Sánchez-Vicente, Zining Yang et autres

Parkinson's disease is the second leading neurodegenerative disease, pathologically characterized by the accumulation of alpha-synuclein in the brain and the loss of dopaminergic neurons in the substantia nigra pars compacta. Despite the intensive efforts to identify diagnostic biomarkers for Parkinson's disease nominating …

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Study of circulating blood linear RNA nominates CD55 and DLD as novel causal genes and early-stage biomarkers for Parkinson’ s disease

Aleksandra Beric, Sarp Sahin, Santiago Sanchez, Zining Yang et autres

Identifying non-invasive Parkinson’s disease (PD) biomarkers is crucial for improving disease diagnosis and monitoring. We analyzed transcriptomic profiles from four major PD studies to identify circulating PD-associated transcripts that could serve as biomarkers. Differential expression (DE) analyses were conducted in four independent …

Leveraging Cutting‐Edge NULISA Technology for Proteomic Profiling and Biomarker Discovery in Autosomal Dominant Alzheimer's Disease

Aleksandra Beric, Wenjing Lin, Gina M. Jerome, Matthew R. Minton et autres

Abstract Background Early disease detection, preceding the onset of symptoms, continues to be one of the biggest challenges in AD research. Individuals that carry AD‐causing mutations provide the perfect opportunity to characterize the natural course of proteomic changes while the new NULISA …

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Orthogonal validation of PD Biomarkers: Multi-platform proteomics profiling of CSF, Plasma, and Urine confirms DDC as a consistent candidate

Ravindra Kumar, Aleksandra Beric, Daniel Western, Zining Yang et autres

Abstract Background High throughput proteomics has enabled hypothesis free biomarker discovery. However, differences in sample sizes, biological fluid, and quantification technologies have limited replication and validation of the results, and studies on the cross-platform variability are lacking. Here, we present the first …

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Motivacijski čimbenici žena poduzetnica u ruralnim krajevima

Aleksandra Beric, Ana Crnčan, Sanja Jelić Milković

Iz popisa stanovništva 2021. godine na području RH utvrđeno je 51 % ženskog stanovništva, dok je u vlasničkoj strukturi trgovačkih društava broj žena u laganom porastu. Od ukupnog broja trgovačkih društava u RH 2023. godine, 21,4 % bilo je isključivo u vlasništvu …

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A Comprehensive Study of Circulating Blood Linear RNA nominates CD55 and DLD as novel causal genes and early-stage biomarkers for Parkinson’s Disease

Aleksandra Beric, Sarp Sahin, Santiago Sánchez-Vicente, Zining Yang et autres

ABSTRACT We leveraged transcriptomic data from 4,343 participants from four independent datasets to robustly identify and annotate circulating PD-associated transcripts. We identified 296 differentially expressed transcripts, 28 of which were transcribed from known PD-associated loci. Further, we found a significant overlap between …

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Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum

Muhammad Ali, Jigyasha Timsina, Daniel Western, Menghan Liu et autres

Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a …

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„Kuća moje baštine“ – spoj tradicije i modernog načina življenja

Aleksandra Beric, Tihana Sudarić, Ana Crnčan

Kao posljedica fenomena proizašlog iz današnjeg urbanog brzog stila života, kod velikog broja stanovništva javlja se želja za povratkom prirodi. Postojeći prirodni i kulturni resursi slavonskog kraja pogoduju razvoju agroturizma, a time se otvara bezbroj mogućnosti razvoja nekog ruralnog područja. Uz razvoj …

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Multi‐cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer’s disease

Muhammad Ali, Jigyasha Timsina, Yuanyuan Shen, Anh Do et autres

Abstract Background Changes in Amyloid‐β (A) and hyperphosphorylated Tau (T) in the brain and cerebrospinal fluid (CSF) precedes AD symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Method We used the Somascan …

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