Serena Ceddia

Molecular tumor board availability and organization in sarcoma referral centers in Italy: are we on the right track?

Concetta Elisa Onesti, Beatrice Casini, Annarosaria De Chiara, Valentina Fausti et autres

Background: With the rapid progress of molecular medicine, new target therapies for solid tumors have become available, leading to the creation of molecular tumor boards (MTBs) designated to evaluate potential individualized treatment options. Unlike other solid or liquid tumors, there is no …

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108P Giant cell tumor of bone: A retrospective analysis from a sarcoma referral center

F. Riva, C.E. Onesti, S. Vari, Serena Ceddia et autres

Giant cell tumor of bone (GCTB) is a primary bone neoplasm, generally benign but often presents locally behaviour. Despite available surgical and systemic treatments, optimal management remains challenging.

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Virtual sarcoma disease multidisciplinary team: a successful experience in the era of telemedicine and COVID-19 in Italy

Francesca Salvatori, Bárbara Rossi, Concetta Elisa Onesti, Sabrina Vari et autres

Background Due to their rarity and complexity sarcomas require specialized multidisciplinary team management. COVID-19 pandemic brought to a rapid implementation of telemedicine and activation of digital tools. This study evaluates the perception of virtual disease multidisciplinary team among healthcare professionals of an …

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Case Report: Malignant transformation of maxillary giant cell tumor of bone from EURACAN reference center

Federica Riva, Sabrina Vari, Concetta Elisa Onesti, Renato Covello et autres

Giant cell tumor of bone (GCTB) is a benign but locally aggressive neoplasm that can rarely undergo malignant transformation, with a poor prognosis. The most frequent histotypes of the sarcomatous transformation of GCTB are osteosarcoma, fibrosarcoma, and undifferentiated pleomorphic sarcoma, and the …

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Prediction of tumor response to neoadjuvant chemotherapy in high-grade osteosarcoma using clustering-based analysis of magnetic resonance imaging: an exploratory study

Giovanni Benvenuti, Simona Marzi, Antonello Vidiri, Jacopo Baldi et autres

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Narrative Medicine: A Digital Diary in the Management of Patients with Bone and Soft Tissue Sarcoma—A Multidisciplinary Pilot Study

Maria Cecilia Cercato, Concetta Elisa Onesti, Sabrina Vari, Gabriella Maggi et autres

Although patient narratives have been increasingly introduced in various fields of medicine, a standard method in clinical practice is still lacking. The objectives of this pilot study were to evaluate the feasibility and usefulness of a digital narrative diary integrated into the …

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Psoriasis induced by first‑line pembrolizumab in metastatic non‑small cell lung cancer: A case report

Federica Gatti, Gianluca Caruso, Concetta Potenza, Daniele Santini et autres

Therapeutic options for non-small cell lung cancer (NSCLC) have changed with the introduction of immune checkpoint inhibitors. Immunotherapy is generally well tolerated, but can also be associated with severe adverse events, such as the development of new autoimmune diseases. In patients without …

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KRAS-Mutant Non-Small-Cell Lung Cancer: From Past Efforts to Future Challenges

Serena Ceddia, Lorenza Landi, Federico Cappuzzo

KRAS is the most frequently mutated oncogene identified in human cancers. Despite the numerous efforts to develop effective specific inhibitors against KRAS, this molecule has remained “undruggable” for decades. The development of direct KRAS inhibitors, such as sotorasib, the first FDA-approved drug …

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Analysis of Molecular Biomarkers in Resected Early-Stage Non-Small Cells Lung Cancer: A Narrative Review

Filippo Tommaso Gallina, Luca Bertolaccini, Daniele Forcella, Shehab Mohamed et autres

Next-generation sequencing has become a cornerstone in clinical oncology practice and is recommended for the appropriate use of tailored therapies in NSCLC. While NGS has already been standardised in advanced-stage NSCLC, its use is still uncommon in the early stages. The recent …

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3MO Oncogenic non-G12C KRAS mutations in KRAS G12C mutated lung adenocarcinomas in TRACERx and GENIE: A reservoir for intrinsic resistance to KRAS G12C inhibitors

Daniele Marinelli, Simona Pisegna, M. Giammaruco, Paolo Chesi et autres

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Nodal Upstaging Evaluation After Robotic-Assisted Lobectomy for Early-Stage Non-small Cell Lung Cancer Compared to Video-Assisted Thoracic Surgery and Thoracotomy: A Retrospective Single Center Analysis

Filippo Tommaso Gallina, Enrico Melis, Daniele Forcella, Edoardo Mercadante et autres

Introduction: The standard surgical procedures for patients with early-stage NSCLC is lobectomy-associated radical lymphadenectomy performed by using the thoracotomy approach. In the last few years, minimally invasive techniques have increasingly strengthened their role in lung cancer treatment, especially in the early stage …

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Treatment of brain metastases in ALK-positive non-small cell lung cancer

Serena Ceddia, Giovanni Codacci-Pisanelli

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