Roma Sunder

CDKN1B inactivation impacts ER signaling and drives resistance to endocrine therapy in breast cancer

Suhail Ahmad, Ashwin B. Butle, Akshay Karn, Roma Sunder et autres

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Genomic characterization of AI resistance in hormone receptor-positive breast cancer using LTED cell line models

Suhail Ahmad, Neetu Tyagi, Duleswar Singh, Akshaya Suresh et autres

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Progesterone modulates the DSCAM-AS1/miR-130a/ESR1 axis to suppress cell invasion and migration in breast cancer

Neelima Yadav, Roma Sunder, Sanket Desai, Bhasker Dharavath et autres

BACKGROUND: A preoperative-progesterone intervention increases disease-free survival in patients with breast cancer, with an unknown underlying mechanism. We elucidated the role of non-coding RNAs in response to progesterone in human breast cancer. METHODS: Whole transcriptome sequencing dataset of 30 breast primary tumors …

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Fusobacterium nucleatum is associated with inflammation and poor survival in early-stage HPV-negative tongue cancer

Sanket Desai, Bhasker Dharavath, Sujith Manavalan, Aishwarya Rane et autres

Abstract Persistent pathogen infection is a known cause of malignancy, although with sparse systematic evaluation across tumor types. We present a comprehensive landscape of 1060 infectious pathogens across 239 whole exomes and 1168 transcriptomes of breast, lung, gallbladder, cervical, colorectal, and head …

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Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations

Asim Joshi, Rohit Mishra, Sanket Desai, Pratik Chandrani et autres

// Asim Joshi 1 , 4 , Rohit Mishra 1 , Sanket Desai 1 , 4 , Pratik Chandrani 2 , 4 , 5 , Hitesh Kore 1 , Roma Sunder 1 , Supriya Hait 1 , 4 , Prajish Iyer 1 …

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A one-step, one-tube real-time RT-PCR based assay with an automated analysis for detection of SARS-CoV-2

Bhasker Dharavath, Neelima Yadav, Sanket Desai, Roma Sunder et autres

Early diagnosis of SARS-CoV-2 infected patients is essential to control the dynamics of the COVID-19 pandemic. We develop a rapid and accurate one-step multiplex TaqMan probe-based real-time RT-PCR assay, along with a computational tool to systematically analyse the data. Our assay could …

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