Daan Gilissen

Comprehensive lincRNA Transcriptome in Acute Myeloid Leukemia: Integrating Known and Newly Identified lincRNAs Across Pediatric and Adult Cohorts

Saioa Arza-Apalategi, Daan Gilissen, Anne C. van der Grinten, Seline N. van den Oever et autres

Background/Objectives: Acute myeloid leukemia (AML) comprises genetic subclasses with distinct gene expression profiles. While AML gene expression studies have mainly focused on protein-coding genes, our understanding of expression patterns of long intergenic noncoding RNAs (lincRNAs) remains incomplete. This is due to limited …

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HMX3 is a critical vulnerability in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia

Saioa Arza-Apalategi, Branco M. H. Heuts, Saskia M. Bergevoet, Roos Meering et autres

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Genetic Classification of Acute Myeloid Leukemia By Differential Long Noncoding RNA Expression

Saioa Arza-Apalategi, Daan Gilissen, Anne van der Grinten, Heuts Branco et autres

Long noncoding RNAs (lncRNAs) are >200 nucleotides in size, lack protein coding potential, and together represent ~2% of the human genome. LncRNAs control important biological processes like cell division, - differentiation and apoptosis. They do this by binding chromatin, RNA, and proteins …

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GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation

Jeron Venhuizen, Maaike G.J.M. van Bergen, Saskia M. Bergevoet, Daan Gilissen et autres

Abstract The transcription factor Growth Factor Independence 1B (GFI1B) recruits Lysine Specific Demethylase 1 A (LSD1/KDM1A) to stimulate gene programs relevant for megakaryocyte and platelet biology. Inherited pathogenic GFI1B variants result in thrombocytopenia and bleeding propensities with varying intensity. Whether these affect …

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The neuronal homeobox transcription factor HMX3 is a crucial vulnerability factor in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia

Saioa Arza-Apalategi, Branco M. H. Heuts, Saskia M. Bergevoet, Roos Meering et autres

Abstract The KMT2A::MLLT3 fusion protein causes acute myeloid leukemia (AML) by activating the oncogenic transcription factor MECOM. However, MECOM expression occurs in only half of the KMT2A::MLLT3 cases. By integrating gene expression and enhancer activity data from patient cells, we identified neuronal …

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High expression of an intragenic long noncoding RNA misinterpreted as high FTO oncogene expression in NPM1 mutant acute myeloid leukemia

Saioa Arza-Apalategi, Branco M. H. Heuts, Meike T. M. Dooijes, Daan Gilissen et autres

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Front Cover, Volume 40, Issue 8

Laurens Wiel, Coos A. B. Baakman, Daan Gilissen, Joris A. Veltman et autres

On the Front Cover: The front cover image is based on the Paper MetaDome: Pathogenicity analysis of genetic variants through aggregation of homologous human protein domains by Laurens Wiel et al., DOI: 10.1002/humu.23798.

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MetaDome: Pathogenicity analysis of genetic variants through aggregation of homologous human protein domains

Laurens Wiel, Coos A. B. Baakman, Daan Gilissen, Joris A. Veltman et autres

The growing availability of human genetic variation has given rise to novel methods of measuring genetic tolerance that better interpret variants of unknown significance. We recently developed a concept based on protein domain homology in the human genome to improve variant interpretation. …

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MetaDome: Pathogenicity analysis of genetic variants through aggregation of homologous human protein domains

Laurens Wiel, Coos A. B. Baakman, Daan Gilissen, Joris A. Veltman et autres

Abstract The growing availability of human genetic variation has given rise to novel methods of measuring genetic tolerance that better interpret variants of unknown significance. We recently developed a novel concept based on protein domain homology in the human genome to improve …

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