Dao-zhen Xu

Effects of intracoronary tirofiban combined with glonoin injection on STEMI patients treated by emergency percataneous coronary artery

Degang Li, Dao-zhen Xu, Yunguo Chen

Objective To investigate the effect of intracoronary tirofiban combined with glonoin alternate injection on STEMI patients treated by emergency percataneous coronary artery. Methods A total of 69 patients with STEMI undergoing emergency PCI were randomly divided into the control group and the …

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Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients

Chenliang Zhou, Chaofan Li, Guozhong Gong, Shuang Wang et autres

An HBsAg-HBIG therapeutic vaccine (Yeast-derived Immune Complexes, YIC) for chronic hepatitis B (CHB) patients has undergone a series of clinical trials. The HBeAg sero-conversion rate of YIC varied from 21.9% to 14% depending on the immunization protocols from 6 to 12 injections. …

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A research on the antiviral treatment of hepatitis C cirrhosis and its related factors

Caiqin Mu, Lu Zhang, Yao Lu, Shuling Wu et autres

Objective To investigate the sustained virological response (SVR) of patients with hepatitis C cirrhosis and its related factors. Method According to their clinical characteristics, 129 patients of hepatitis C cirrhosis were injected Pegasys (Peg-IFNα2a) and ribavirin (15 mg/kg/d). The serum HCV RNA …

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HBsAg and HBeAg in the prediction of a clinical response to peginterferon α-2b therapy in Chinese HBeAg-positive patients

Song Yang, Huichun Xing, Yuming Wang, Jinlin Hou et autres

BACKGROUND: This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course of pegylated interferon alfa-2b therapy at 1.5 …

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[Efficacy of pegylated-interferon alpha-2a treatment in patients with HBeAg-positive chronic hepatitis B and partial viral response to nucleoside analogue therapy].

Minghui Li, Leiping Hu, Lu Zhang, Yao Lu et autres

OBJECTIVE: To investigate the efficacy and related factors of pegylated-interferon alpha-2a (PEG-IFN-2a) treatment in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) who achieved partial viral response with nucleoside analogue (NA) therapy. METHODS: Patients with HBeAg-positive CHB and partial …

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Peginterferon alfa-2b in the treatment of Chinese patients with HBeAg-positive chronic hepatitis B: A randomized trial

Jun Cheng, Yuming Wang, Jinlin Hou, Qing Xie et autres

BACKGROUND: In mainland China, peginterferon (PEG-IFN) alfa-2b 1.0μg/kg/wk for 24 weeks is the approved treatment for HBeAg-positive chronic hepatitis B. OBJECTIVE: This multicenter, randomized trial evaluated the safety and efficacy of regimens utilizing increased dose or treatment duration in treatment-naive Chinese patients …

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[Comparative analysis of the efficacies of entecavir capsules and lamivudine in chronic hepatitis B patients].

Dao-zhen Xu, Haodong Cai, Ma Xiuyun, Yue-qi Li et autres

OBJECTIVE: To investigate the efficacy profile of entecavir capsule (ETV) as a chronic hepatitis B therapy, as compared to lamivudine (LAM). METHODS: In this multicenter, randomized, double-blind, parallel group evaluation of ETV, 232 subjects were administered a 96-week course of 0.5 mg/day …

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Two-year results of a randomized, phase III comparative trial of telbivudine versus lamivudine in Chinese patients

Jidong Jia, Jinlin Hou, You‐Kuan Yin, Deming Tan et autres

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[Analyse related factors of impact and prognosis of 73 cases of severe hepatitis].

Junmei Zhao, Lu Zhang, Qing-Wei Du, Caiqin Mu et autres

OBJECTIVE: A retrospective study was conducted to investigate the clinical features and prognostic factors of 73 cases of severe hepatitis. METHODS: To summarize clinical features of 73 cases of severe hepatitis, grouping by etiology and pathogenesis. A retrospective analysis was performed to …

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The Predictive Value of On-treatment Virological Response for Sustained Virological Response in Chronic Hepatitis C Patients Receiving a Personalized Treatment Program

Minghui Li, Yao Xie, Yao Lu, Guo‐Hua Qiu et autres

Abstract Objective To investigate the effects of individualised treatment with peginterferon alpha-2a (40 kD) plus ribavirin in Chinese patients with CHC. Methods Total of 297 consecutive Chinese patients were enrolled, including 250 naïve cases and 47 cases who were previously treated. Treatment …

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Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings

Dao-zhen Xu, Xuanyi Wang, Xinliang Shen, Guozhong Gong et autres

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[Study on effect of intensive treatment for refractory chronic hepatitis C patients].

Minghui Li, Yanli Zhang, Lu Zhang, Ge Shen et autres

OBJECTIVE: To explore the effect of intensive treatment for refractory chronic hepatitis C, and to improve the sustained viral response (SVR) rate of treatment with interferon plus ribavirin by optimizing therapeutic dose and course. METHODS: Patients who did not acquire response or …

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