Accès ouvert
2024
article
OpenAlex
Na Sun, Tanja Krauss, Claudine Seeliger, Thomas Kunzke et autres
BACKGROUND: Cancer cachexia (CCx) presents a multifaceted challenge characterized by negative protein and energy balance and systemic inflammatory response activation. While previous CCx studies predominantly focused on mouse models or human body fluids, there's an unmet need to elucidate the molecular inter-organ …
de, us
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Accès ouvert
2023
article
OpenAlex
Alexandra Chovsepian, Olga Prokopchuk, Gabriela Petrova, Tefta Gjini et autres
Cancer is considered an emerging diabetes complication, with higher incidence and worse prognosis in patients with diabetes. Cancer is frequently associated with cachexia, a systemic metabolic disease causing wasting. It is currently unclear how diabetes affects the development and progression of cachexia. …
de
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Accès ouvert
2023
article
OpenAlex
Tanja Krauss, Simone Heisz, Julius Honecker, Olga Prokopchuk et autres
BACKGROUND: Cancer cachexia (CCx) is a complex and multi-organ wasting syndrome characterized by substantial weight loss and poor prognosis. An improved understanding of the mechanisms involved in the onset and progression of cancer cachexia is essential. How microRNAs contribute to the clinical …
de, us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Celina Eckfeld, Benjamin Schoeps, Daniel Häußler, Julian Frädrich et autres
The emerging cytokine tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with the progression of inflammatory diseases, including cancer. However, the effects of TIMP-1 on immune cell activation and underlying molecular mechanisms are largely unknown. Unbiased ligand-receptor-capture-screening revealed TIMP-1-interaction with Amyloid Precursor Protein (APP) …
de
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Accès ouvert
2021
article
OpenAlex
Julius Honecker, Dominik Weidlich, Simone Heisz, Cecilia M. Lindgren et autres
Abstract Objective Cell diameter, area, and volume are established quantitative measures of adipocyte size. However, these different adipocyte sizing parameters have not yet been directly compared regarding their distributions. Therefore, the study aimed to investigate how these adipocyte size measures differ in …
de, us, gb
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Accès ouvert
2019
article
OpenAlex
Thomas Kunzke, Achim Buck, Verena M. Prade, Annette Feuchtinger et autres
BACKGROUND: Cachexia is the direct cause of at least 20% of cancer-associated deaths. Muscle wasting in skeletal muscle results in weakness, immobility, and death secondary to impaired respiratory muscle function. Muscle proteins are massively degraded in cachexia; nevertheless, the molecular mechanisms related …
de
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