Claudine Seeliger

Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice

Sarah Patricia Brunner, Johannes Plagge, Maria Zimmermann‐Kogadeeva, Marcus Höring et autres

The gut microbiota influences host metabolism, but the mechanisms of lipid uptake from food remain mysterious. Here we used stable isotope-labelled tracers in gnotobiotic mouse models, which revealed that host uptake of dietary lipids depends on microbial colonization. Systemic lipid metabolism modelling …

Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice

Sarah Patricia Brunner, Johannes Plagge, Maria Zimmermann‐Kogadeeva, Marcus Höring et autres

The gut microbiota influences host metabolism, but the mechanisms of lipid uptake from food remain mysterious. Here we used stable isotope-labelled tracers in gnotobiotic mouse models, which revealed that host uptake of dietary lipids depends on microbial colonization. Systemic lipid metabolism modelling …

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Inhibition of ceramide synthesis ameliorates body wasting in a cancer cachexia model

Pauline Morigny, Honglei Ji, Laura Cussonneau, Sabrina Zorzato et autres

Cachexia is a metabolic wasting syndrome affecting many patients with cancer, with poor survival outcomes. Disturbed lipid metabolism is a hallmark of cachexia, and our previous work has identified increased levels of circulating ceramides, which are bioactive lipids with adverse effects in …

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Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer

Pauline Morigny, Michaela Vondráčková, Honglei Ji, Kristýna Brejchová et autres

Abstract Cachexia is a wasting disorder associated with high morbidity and mortality in patients with cancer. Tumour–host interaction and maladaptive metabolic reprogramming are substantial, yet poorly understood, contributors to cachexia. Here we present a comprehensive overview of the spatio-temporal metabolic reprogramming during …

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Sex-specific response of the human plasma lipidome to short-term cold exposure

Marcus Höring, Sarah Patricia Brunner, Josef Scheiber, Julius Honecker et autres

Cold-induced lipolysis is widely studied as a potential therapeutic strategy to combat metabolic disease, but its effect on lipid homeostasis in humans remains largely unclear. Blood plasma comprises an enormous repertoire in lipids allowing insights into whole body lipid homeostasis. So far, …

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Inter-organ cross-talk in human cancer cachexia revealed by spatial metabolomics

Na Sun, Tanja Krauss, Claudine Seeliger, Thomas Kunzke et autres

BACKGROUND: Cancer cachexia (CCx) presents a multifaceted challenge characterized by negative protein and energy balance and systemic inflammatory response activation. While previous CCx studies predominantly focused on mouse models or human body fluids, there's an unmet need to elucidate the molecular inter-organ …

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Mitochondrial lipidomes are tissue specific – low cholesterol contents relate to UCP1 activity

Sarah Patricia Brunner, Marcus Höring, Gerhard Liebisch, Sabine Schweizer et autres

Lipid composition is conserved within sub-cellular compartments to maintain cell function. Lipidomic analyses of liver, muscle, white and brown adipose tissue (BAT) mitochondria revealed substantial differences in their glycerophospholipid (GPL) and free cholesterol (FC) contents. The GPL to FC ratio was 50-fold …

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Feasibility of omega‐3 fatty acid fraction mapping using chemical shift encoding‐based imaging at 3 T

Julius Honecker, Olga Prokopchuk, Claudine Seeliger, Hans Hauner et autres

PURPOSE: The aim of this work is to develop an ω-3 fatty acid fraction mapping method at 3 T based on a chemical shift encoding model, to assess its performance in a phantom and in vitro study, and to further demonstrate its …

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Specific miRNAs are associated with human cancer cachexia in an organ‐specific manner

Tanja Krauss, Simone Heisz, Julius Honecker, Olga Prokopchuk et autres

BACKGROUND: Cancer cachexia (CCx) is a complex and multi-organ wasting syndrome characterized by substantial weight loss and poor prognosis. An improved understanding of the mechanisms involved in the onset and progression of cancer cachexia is essential. How microRNAs contribute to the clinical …

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Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density

Sabrina Ehnert, Anna Janine Schreiner, Claudine Seeliger, Josef Ecker et autres

FA10:0, FA14:1, or FA16:1 n-7 in the bone marrow or FA18:0, FA18:1 n-9, FA18:1 n-7, FA20:0, FA20:1 n-9, or FA20:3 n-6 in the plasma, correlated with osteoclast activity, suggesting a possible mechanism how these fatty acids may interfere with BMD. Although several …

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Dietary PUFA Preferably Modify Ethanolamine-Containing Glycerophospholipids of the Human Plasma Lipidome

Christine Dawczynski, Johannes Plagge, Gerhard Jahreis, Gerhard Liebisch et autres

The content of polyunsaturated fatty acids (PUFA) in complex lipids essentially influences their physicochemical properties and has been linked to health and disease. To investigate the incorporation of dietary PUFA in the human plasma lipidome, we quantified glycerophospholipids (GPL), sphingolipids, and sterols …

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miR-375 is cold exposure sensitive and drives thermogenesis in visceral adipose tissue derived stem cells

Claudine Seeliger, Tanja Krauss, Julius Honecker, Laura Aline Mengel et autres

Activation of brown adipose tissue may increase energy expenditure by non-shivering thermogenesis. Cold exposure is one of the options to activate brown adipocytes. To link changes in energy metabolism with microRNA expression (miRNAs), we analyzed 158 miRNAs in serum of 169 healthy …

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