Kwun Nok Mimi Man

Stimulation of Ca 2+ channel Ca V 1.2 activity by dopamine signaling augments spatial working memory

Kwun Nok Mimi Man, Sarah L. S. Rougé, Ruben A. Berumen, Ariel A. Jacobi et autres

Dopamine drives the neuronal activity and synaptic plasticity required for various forms of learning. It supports short-term working memory through activation of the D 1 -like dopamine receptors D 1 and D 5 . Here, we found that the L-type Ca 2+ …

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Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity

Xiaomin Xing, Erik A Hammes, Zoila M. Estrada‐Tobar, Karam Kim et autres

Signaling by norepinephrine (NE) via adrenergic receptors (ARs) mediates attention, yet the underlying molecular mechanisms are largely unknown. AMPA receptors (AMPARs) form a complex with β 2 ARs, G s , adenylyl cyclase, and protein kinase A (PKA) to augment AMPAR phosphorylation …

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α1 C S1928 Phosphorylation of Ca V 1.2 Channel Controls Vascular Reactivity and Blood Pressure

Víctor A. Flores-Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Jade L. Taylor et autres

Background Increased vascular Ca V 1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothesize that α1 C phosphorylation at serine 1928 …

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High-speed two-photon microscopy with adaptive line-excitation

Yunyang Li, Ben Mattison, Junjie Hu, Kwun Nok Mimi Man et autres

We present a two-photon fluorescence microscope designed for high-speed imaging of neural activity at cellular resolution. Our microscope uses an adaptive sampling scheme with line illumination. Instead of building images pixel by pixel via scanning a diffraction-limited spot across the sample, our …

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List of contributors

Catarina M. Abreu, Prachi Agarwal, Olatunji Ajiteru, Antonio Alessandrino et autres

pt, in, kr, it, ir, au, th, cn, gb, hk, es (code pays fourni par la source)

Next-generation sequencing of AAV.CAP-Mac from Chuapoco et al. (2023) Nature Nanotechnology

Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden, J. Christopher Octeau et autres

Dataset of next-generation sequencing of enrichment of AAV.CAP-Mac in various tissues from the publication: Chuapoco, M.R., Flytzanis, N.C., Goeden, N. et al. Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain. Nat. Nanotechnol. (2023). https://doi.org/10.1038/s41565-023-01419-x

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Next-generation sequencing of AAV.CAP-Mac from Chuapoco et al. (2023) Nature Nanotechnology

Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden, J. Christopher Octeau et autres

Dataset of next-generation sequencing of enrichment of AAV.CAP-Mac in various tissues from the publication: Chuapoco, M.R., Flytzanis, N.C., Goeden, N. et al. Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain. Nat. Nanotechnol. (2023). https://doi.org/10.1038/s41565-023-01419-x

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Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain

Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden, J. Christopher Octeau et autres

Crossing the blood-brain barrier in primates is a major obstacle for gene delivery to the brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the bloodstream to the brain. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood-brain barrier …

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α1-Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca2+ channel CaV1.2 activity and long-term potentiation in rodents

Kwun Nok Mimi Man, Peter H. Bartels, Peter B. Henderson, Karam Kim et autres

The cellular mechanisms mediating norepinephrine (NE) functions in brain to result in behaviors are unknown. We identified the L-type Ca 2+ channel (LTCC) Ca V 1.2 as a principal target for G q -coupled α 1 -adrenergic receptors (ARs). α 1 AR …

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Author response: α1-Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca2+ channel CaV1.2 activity and long-term potentiation in rodents

Kwun Nok Mimi Man, Peter H. Bartels, Peter B. Henderson, Karam Kim et autres

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S1928 Phosphorylation Control CaV1.2 Spatial Distribution and Function During Angiotensin II Signaling: Implications for Hypertension

Victor Flores Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Navid Singhrao et autres

The L-type calcium channel CaV1.2 (LTCC) is essential for vascular smooth muscle (VSM) contraction and blood pressure control. Increased vascular contractility, blood pressure, and enhanced angiotensin II (angII) signaling are hallmarks of hypertension (HTN). It has been proposed that spatial redistribution of …

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Intravenous functional gene transfer throughout the brain of non-human primates using AAV

Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden, J. Christopher Octeau et autres

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