Yizhi Zhan

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

Yizhi Zhan, XU Jin-song, Zhanqiao Zhang, Yating Hu et autres

Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM. Sphingosine kinase 1 (SPHK1) serves …

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Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer

Y. Liu, Zhengyu Liu, Yating Hu, Yunyan Ling et autres

Colorectal cancer (CRC) is a leading global health issue, ranking third in incidence and second in cancer mortality. Immunotherapy, effective mainly in mismatch repair-deficient CRC, may benefit from dietary interventions. This study investigates caffeine’s potential to boost programmed death-1 (PD-1) immunotherapy efficacy …

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Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity

Yuwen Xie, Yang Liu, Mingdao Lin, Zhenkang Li et autres

Proposed working model of targeting ATM for enhancing the radiation sensitivity of colorectal cancer. Targeting ATM increased IR-induced ROS levels, which not only triggers apoptosis but also aggravates mitochondrial damage, and facilitates cytosolic mtDNA-induced STING type-I IFN signaling. Activation of this pathway …

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Spermine synthase engages in macrophages M2 polarization to sabotage antitumor immunity in hepatocellular carcinoma

Yining Sun, Peitao Zhou, Junying Qian, Qin Zeng et autres

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DYNLL1 accelerates cell cycle via ILF2/CDK4 axis to promote hepatocellular carcinoma development and palbociclib sensitivity

Y. Liu, Zhenkang Li, Jinchao Zhang, Wei Liu et autres

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Spermine Synthase Engages in Macrophages M2 polarization to Sabotage Antitumor Immunity in Hepatocellular Carcinoma

Yuan Fang, Yining Sun, Peitao Zhou, Qin Zeng et autres

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Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2

Yilin Zheng, Yizhi Zhan, Yuqin Zhang, Yaowei Zhang et autres

With technological advancements, radiotherapy (RT) has become an effective non-surgical treatment for hepatocellular carcinoma (HCC), comprehensively improving the local control rate of patients with HCC. However, some patients with HCC still experience radio-resistance, cancer recurrence, and distant metastasis following RT. Our previous …

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Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity

Yongsheng Li, Zhiyong Shen, Zhen Chai, Yizhi Zhan et autres

Objective Checkpoint immunotherapy unleashes T-cell control of tumours but is suppressed by immunosuppressive myeloid cells. The transmembrane protein MS4A4A is selectively highly expressed in tumour-associated macrophages (TAMs). Here, we aimed to reveal the role of MS4A4A + TAMs in regulating the immune …

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The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis

Yongjia Wang, Yu‐Qin Zhang, Zixuan Wang, Lu Yu et autres

Nuclear protein 1 (NUPR1) is a transcriptional coregulator that has been implicated in the development of various cancer types. In addition, de novo fatty acid synthesis plays a pivotal role in hepatocellular carcinoma (HCC) development. However, little is currently known on the …

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NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma

Yizhi Zhan, Zhanqiao Zhang, Yuechen Sophia Liu, Yuan Fang et autres

BACKGROUND: Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular carcinoma (HCC). Ionizing radiation (IR) inducing the generation of reactive oxygen species (ROS) leads to a promising antitumor effect. However, the dysregulation of the redox system often causes radioresistance and …

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HAO1-mediated oxalate metabolism promotes lung pre-metastatic niche formation by inducing neutrophil extracellular traps

Zhicheng Zeng, Shaowan Xu, Feifei Wang, Xin Peng et autres

Metabolic reprogramming has been shown to be involved in cancer-induced pre-metastatic niche (PMN) formation, but the underlying mechanisms have been insufficiently explored. Here, we showed that hydroxyacid oxidase 1 (HAO1), a rate-limiting enzyme of oxalate synthesis, was upregulated in the alveolar epithelial …

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GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer

Zhiyong Shen, Zhenkang Li, Yuechen Liu, Yongsheng Li et autres

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Abundant metabolic fuels have been implicated as potential drivers of CRC. However, it remains unclear whether fructose, an ample sugar in daily diets, is essential for CRC growth. In the present …

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