Emma Holmes

Landscape as a Shared Space for Badgers and Cattle: Insights Into Indirect Contact and Bovine Tuberculosis Transmission Risk

Emma Holmes, Maria O’Hagan, F. D. Menzies, Andrew W. Byrne et autres

ABSTRACT Though the magnitude of effect is uncertain, badger–cattle indirect contact has been implicated in bovine tuberculosis (bTB) transmission risk to cattle despite a paucity of data on badger space use. This study tracked field use by 35 GPS‐collared bTB test‐negative badgers …

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Handling of Human Ejaculate Affects Osmolality and Yield by Density Gradient Centrifugation and Possibly Also Sperm DNA Integrity

Emma Holmes, Petr Houska, Lars Björndahl, Ulrik Kvist

During routine handling in the assisted reproductive technology (ART) laboratory, the osmolality of the ejaculate increases, and live spermatozoa adapt to this increase. Preparation media are generally isotonic, having an osmolality of ~290 mOsm/kg. Therefore, when the ejaculate is placed on a …

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Genotypic analysis of a localised hotspot of Pestivirus A (BVDV‐1) infections in Northern Ireland

James McConville, Adrian Allen, Asa Moyce, Aoibheann Donaghy et autres

BACKGROUND: Bovine viral diarrhoea (BVD) is caused by Pestivirus A and Pestivirus B. Northern Ireland (NI) embarked on a compulsory BVD eradication scheme in 2016, which continues to this day, so an understanding of the composition of the pestivirus genotypes in the …

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Impacts of genotypic variants on survival following reoperation for recurrent glioblastoma

Antonio Dono, Ping Zhu, Emma Holmes, Takeshi Takayasu et autres

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SURG-23. REOPERATION IN MOLECULAR SUBTYPES OF RECURRENT GLIOBLASTOMA

Antonio Dono, Ping Zhu, Emma Holmes, Takeshi Takayasu et autres

Abstract BACKGROUND Recurrent glioblastoma (rGBM) treatment is not well defined and multiple therapeutic approaches have been proposed, none of which has shown to prolong survival in randomized trials. The role of reoperation for rGBM is still unclear. While most studies demonstrate improve …

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Hypotonic challenge reduces human sperm motility through coiling and folding of the tail

Emma Holmes, Lars Björndahl, Ulrik Kvist

Human ejaculates collected for in vitro procedures show variably rapid increases in osmolality, depending on enzymatic degradation of compounds. Changes in osmolality can affect cell functions due to the energy consuming processes needed to control cell volume. The aim was to examine …

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On osmolality and sperm function during processing for assisted reproduction

Emma Holmes

Deep basic knowledge about sperm physiology is relevant and important to optimize the outcome of procedures used during Assisted Reproductive Technologies (ART) to select spermatozoa for fertilization. More specifically, this study examined osmolality changes and consequences for sperm motility and sperm selection …

SURG-19. REORGANIZATION OF LANGUAGE ENABLES SAFE RESECTION OF TUMORS IN AND AROUND BROCA’S AREA

Emma Holmes, Keith Kerr, Cihan Mehmet Kadipasaoglu, Nitin Tandon

Abstract INTRODUCTION Since its discovery in the 1800s, Broca’s area has been viewed as a critical node for language production. Previously, pathologies in this area have been considered unresectable due to concern for producing iatrogenic language production deficits. Emerging literature suggests that …

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Possible factors influencing post‐ejaculatory changes of the osmolality of human semen in vitro

Emma Holmes, Lars Björndahl, Ulrik Kvist

The human ejaculate is made up of secretions from the different accessory sex glands that empty in sequence at ejaculation. However, the different secretions only mix completely in vitro when the entire ejaculate is collected in a container and handled in the …

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Post‐ejaculatory increase in human semen osmolality in vitro

Emma Holmes, Lars Björndahl, Ulrik Kvist

Spermatozoa prepared in vitro for assisted reproductive technology (ART) encounter other challenges than in vivo. One could be to survive and function despite varying extracellular osmolality. There is a lack of consistent knowledge of human semen osmolality and changes after liquefaction. The …

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Changes in Biomarkers of Exposure on Switching From a Conventional Cigarette to Tobacco Heating Products: A Randomized, Controlled Study in Healthy Japanese Subjects

Nathan Gale, Alison Eldridge, Ian M. Fearon, N. Sherwood et autres

BACKGROUND: Smoking is a leading cause of numerous human disorders including pulmonary disease, cardiovascular disease, and cancer. Disease development is primarily caused by exposure to cigarette smoke constituents, many of which are known toxicants. Switching smokers to modified risk tobacco products (MRTPs) …

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A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product

Nathan Gale, Alison Eldridge, N. Sherwood, Edward Bowen et autres

BACKGROUND: Smoking is a leading cause of numerous human disorders including lung cancer, chronic obstructive pulmonary disease, and atherosclerotic cardiovascular disease. The development of modified risk tobacco products (MRTPs) has been suggested as a possible way to reduce the risks of tobacco …

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