Michael Boutros

Haemodynamic control of zonated liver function via instructive vascular Wnt signalling

Ki Hong Lee, Moritz Jakab, Alexey Uvarovskii, Dimitris Papageorgiou et autres

The vascular endothelium forms a systemically disseminated organ that translates micromilieu factors into instructive cues, designated as angiocrine signalling. While vascular control of organ function mechanisms have been discovered in essentially all major organs, the mechanisms of translating milieu factors into angiocrine …

de, us (code pays fourni par la source)

Data from "Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping"

Christina Laufer, Bernd Michael Fischer, Maximilian Billmann, Wolfgang K. Huber et autres

Data from Laufer et al. (2013): "Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping". This data was previously available in the HD2013SGI Bioconductor R package: https://bioconductor.posit.co/packages/HD2013SGI/.

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Data from "Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping"

Christina Laufer, Bernd Michael Fischer, Maximilian Billmann, Wolfgang K. Huber et autres

Data from Laufer et al. (2013): "Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping". This data was previously available in the HD2013SGI Bioconductor R package: https://bioconductor.posit.co/packages/HD2013SGI/.

de (code pays fourni par la source)

The PRECISE European initiative for cancer-vulnerability mapping and prediction

Francesco Iorio, Mathew J. Garnett, Pedro Beltrão, Maximilian Billmann et autres

it, gb, ch, de, ie, at, jp, pt, es, us, nl (code pays fourni par la source)

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancer

Theresa Mulholland, Bogac Aybey, Zhenchong Li, Luisa E. Schwarzmüller et autres

Abstract Background Single-cell atlases have described diverse stem cell states in colorectal cancer (CRC), however, the overarching trajectories of those states and the underlying functional mechanisms, including their relevance for drug sensitivity, need better understanding. Methods We established 64 patient-derived organoids from …

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Abstract 3340: Toward large-scale clinical implementation of extracellular vesicle profiling for precision oncology

Antonia Schubert, Nadine Winkler, Robert Ihnatko, Joscha A. Kraske et autres

Abstract Extracellular vesicles (EVs) are nanosized, membrane-bound particles released by all cell types. They carry proteins, nucleic acids, and lipids reflective of their cellular origin and have emerged as promising non-invasive biomarkers for cancer diagnosis and monitoring of therapy response. However, the …

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Improved in vivo gene knockout with high specificity using multiplexed Cas12a sgRNAs

Fillip Port, Martha A Buhmann, Jun Zhou, Mona Stricker et autres

CRISPR nuclease-mediated gene knock-out is limited by suboptimal sgRNAs, inaccessible target sites, and undesired repair outcomes. Here, we present a Cas12a-based system in Drosophila that targets each gene with four sgRNAs to overcome these limitations. Multiplexed sgRNAs act through redundancy and synergism, …

de, pl, us, cn (code pays fourni par la source)

Toll signalling controls intestinal regeneration in Drosophila

Aiswarya Udayakumar, Filippos Stavropoulos, Theodosia Hadjipanteli, Guofan Peng et autres

The intestinal interphase is where epithelial renewal and tissue maintenance are balanced alongside immunological regulation. How these functions integrate with cellular signalling is under investigation. Here, we studied the role of the evolutionarily conserved innate immune Toll/NF-κB pathway in Drosophila intestinal regeneration. …

gb, cy, cn, de, us (code pays fourni par la source)

Cell Bulging and Extrusion in a Three-Dimensional Bubbly Vertex Model for Curved Epithelial Sheets [data]

Oliver M. Drozdowski, Büşra Kocameşe-Tamgacı, Kim E. Boonekamp, Michael Boutros et autres

Cell extrusion is an essential mechanism for controlling cell density in epithelial tissues. Another essential element of epithelia is curvature, which is required to achieve complex shapes, like in the lung or intestine. Here we introduce a three-dimensional bubbly vertex model to …

de (code pays fourni par la source)

Correction: Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila

Alexandre Cammarata-Mouchtouris, Xuan‐Hung Nguyen, Adrian Acker, François Bonnay et autres

[This corrects the article DOI: 10.1371/journal.ppat.1008458.].

Colorectal cancer organoids drive hypoxia, TGF-β, and patient-specific diversification of NK cell activation programs

Andreas von Kries, Irene Garces, Bianca M Balzasch, Carsten Sticht et autres

Background Colorectal carcinoma exhibits high heterogeneity, comprising subtypes that show poor efficacy of T cell-based immunotherapies, such as programmed cell death protein 1 (PD-1) checkpoint inhibitors. Although natural killer (NK) cells are considered a promising approach for cancer immunotherapy, it remains unclear …

de, us (code pays fourni par la source)

Charakterisierung von MEK5 als Zielstruktur zur Radiosensitisierung von kolorektalen Karzinomzellen

Emerich Eichhorn, Calley Stevens Taylor, Anna Klupsch, Q. Xiao et autres

Einleitung: Das kolorektale Karzinom gehört zu den weltweit häufigsten Ursachen für krebsbedingte Mortalität. Insbesondere bei der Therapie des lokal fortgeschrittenen Rektumkarzinoms ist die kombinierte Radiochemotherapie von entscheidender Bedeutung und ermöglicht bei günstigem Therapieansprechen eine organerhaltende Behandlung. Die dabei auftretende Radioresistenz, ob intrinsisch …

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