Xuan‐Hung Nguyen

Correction: Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila

Alexandre Cammarata-Mouchtouris, Xuan‐Hung Nguyen, Adrian Acker, François Bonnay et autres

[This corrects the article DOI: 10.1371/journal.ppat.1008458.].

Molecular analysis of immune cell subsets and cytokine profiles in septic Vietnamese patients

Chien Dinh Huynh, Minh Phương Nguyễn, Xuan‐Hung Nguyen, Tu Dac Nguyen et autres

Sepsis remains a Major global health burden, accounting for an estimated 11 million deaths annually, and is characterized by a profoundly dysregulated host immune response to infection. Despite its significant morbidity and mortality, the immunopathogenesis of sepsis—particularly within underrepresented populations—remains inadequately understood. …

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1286 Developing patient-derived tumor organoid model for drug test in Vietnamese setting

Hai-Son Vu, Minh-Anh Dang Thi, Xuan‐Hung Nguyen

Background Patient-derived tumor organoid (PDTO) represents a clinically relevant model for investigating and predicting therapeutic responses. Vietnam represents a critical yet underexplored setting for organoid-based research and applications.Methods Data are generated using PDTO-based drug sensitivity and clinical input.Results We report a colorectal …

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Safety and efficacy of KRAS antisense oligonucleotides and RIG-I agonists delivered by extracellular vesicles for pancreatic cancer peritoneal metastasis treatment

Xuan Dang, Cao Dai Phung, Lan Thi Ngoc Tran, Phuoc Trong Nguyen et autres

Pancreatic ductal adenocarcinoma (PDAC) often metastasizes to the peritoneum and is highly resistant to treatments due to its immunosuppressive microenvironment. In this study, we evaluate the safety and efficacy of a novel therapeutic strategy that combines KRAS-targeting antisense oligonucleotides (ASOs) with immunomodulatory …

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Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing

Mai Thi Le, Huy Hoang Dao, Xuan‐Hung Nguyen, Van-Tinh Nguyen et autres

Background Non-healing wounds lead to tissue dysfunction, contributing to pathological conditions and compromising overall health. Recently, microRNAs have been shown to regulate diverse biological events, including cell migration, proliferation, angiogenesis, scar formation, and wound closure. Interestingly, cells selectively sort microRNAs into extracellular …

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Current state of microbiota clinical applications in neonatal and pediatric bacterial infections

Thanh T. Le, Dylan Huy, Xuan‐Hung Nguyen, Hang Viet Dao et autres

The microbiota plays a crucial role in pediatric health by shaping immune development and influencing infection susceptibility. In infants and children, an immature microbiota may compromise immune defense, increasing the risk of bacterial infections. This review evaluates clinical trials on the microbiota’s …

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Safety profile of self-amplifying mRNA SARS-CoV-2 vaccine ARCT-154 in adults: a pooled phase 1/2/3 randomized clinical study

Nhan Thi Ho, Igor Smolenov, Lydia Tran, Van Thu Nguyen et autres

BACKGROUND: Public health concerns due to ongoing emergence of SARS-CoV-2 variants necessitates further development of improved COVID-19 vaccines. One major innovation are self-amplifying mRNA vaccines, such as ARCT-154 (Arcturus Therapeutics, Inc.), which induces superior immunogenicity compared with conventional mRNA in terms of …

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Comprehensive Profiling of Immune Cell Populations and Cytokine Signatures in Colorectal Cancer Patients

Chien Dinh Huynh, Minh Phương Nguyễn, Trung Dinh Ngo, Xuan‐Hung Nguyen et autres

Colorectal cancer (CRC) ranks as the fifth most prevalent malignancy in Vietnam. Cytological and molecular assays currently serve as crucial tools for assessing the immune status of patients. Here we document extensive alterations in both the cellular immune system in CRC patients …

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A randomized trial comparing safety, immunogenicity and efficacy of self-amplifying mRNA and adenovirus-vector COVID-19 vaccines

Nhan Thi Ho, Steven G. Hughes, Rose E. Sekulovich, Van Thanh Ta et autres

This phase 3 trial compared safety, tolerability, immunogenicity and efficacy of the self-amplifying mRNA COVID-19 vaccine, ARCT-154, with ChAdOx1-S adenovirus-vector vaccine. In four centers in Vietnam adult participants aged 18‒85 years were randomly assigned to receive two doses, 28 days apart, of …

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Manufacturing exosomes for wound healing: Comparative analysis of culture media

Huy Hoang Dao, Nguyen Thu Huyen, Diem Huong Hoang, Bich Diep Vu et autres

Mesenchymal stem cell (MSC)-derived exosomes (EXs) have emerged as promising therapeutic agents for wound healing. However, the optimal conditions for manufacturing MSC-derived EXs that maximize their wound-healing potential have yet to be established. Hence, we compared the efficacy of five different MSC …

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Design of magneto-inductive waveguide in 2-d magnetic metamaterial structure for wireless power transfer and near-field communications

Xuan Thanh Pham, Xuan‐Hung Nguyen, Khu Vu, Thanh Son Pham

Recently, significant research has been conducted on magnetic metamaterials that exhibit negative permeability and operate within the GHz and MHz frequency ranges. These metamaterial structures can be utilized to improve the efficiency of near-field wireless power transfer systems, subterranean communication, and position …

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Fresh Human Umbilical Cord Arteries as a Potential Source for Small-Diameter Vascular Grafts

Trung-Chuc Nguyen, Toan Linh Nguyen, Xuan‐Hung Nguyen, Khac-Cuong Bui et autres

The demand for small-diameter vascular grafts has been globally increased but still lacks optimal solutions in this category. This study evaluated the feasibility of utilizing human pretreated fresh and nondecellularized umbilical cord arteries (hUCAs) as vascular grafts without needing any immunosuppression process. …

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