Giannalisa Todaro

Allogenic Stem Cell Transplantation from Alfabeta T/Cd19 Depleted Haploidentical Donor as Salvage Therapy in In Heavily Pretreated Relapsed/Refractory Patients with Hodgkin Lymphoma

Lucia Prezioso, Sabrina Bonomini, Roberta Segreto, Benedetta Cambò et autres

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PYGO2 is overexpressed in multiple myeloma patients with 1q21 amplification, driving plasma cell proliferation and cell cycle progression

Nicolas Thomas Iannozzi, Paola Storti, Rosanna Vescovini, Camilla Sitzia et autres

Abstract Chromosome 1q21 copy number alterations (1q21+) are among the most frequent secondary events in multiple myeloma (MM), correlating with poor prognosis and therapy resistance. However, the molecular drivers of this lesion remain poorly defined. Here, we identify PYGO2, a Wnt/β-catenin co-activator …

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Long-term prognostic impact of chromosome 1 abnormalities in newly diagnosed multiple myeloma patients: a monocentric study

Nicolas Thomas Iannozzi, Gabriella Sammarelli, Andrea Poletti, Giannalisa Todaro et autres

The presence of chromosome 1 abnormalities in multiple myeloma (MM) has been included in the more recent prognostic staging system; however, the prognostic role of chromosome 1 abnormalities remains controversial. Thus, in this study we have investigated the prognostic role of chromosome …

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Inhibition of the atypical kinase WNK1 as a therapeutic strategy in TAL-related T-cell acute lymphoblastic leukemia

Anna Montanaro, Gregorio Monica, Raffaella Zamponi, Anna D’Antuono et autres

ABSTRACT: Driver mutations in T-cell acute lymphoblastic leukemia (T-ALL) rarely affect druggable kinases. However, these kinases can be aberrantly activated or repressed as secondary oncogenic events. Thus, integrating unbiased phosphoproteomics with genomic approaches may offer novel opportunities for target discovery and therapeutic …

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Altered osteoblast populations dynamics underlie myeloma progression from precursors diseases in bone microenvironment

Mattia Dessena, Tommaso Torelli, Cristina Manferdini, Camilla Sitzia et autres

Abstract Uncoupled bone-remodelling process characterizes the development of multiple myeloma (MM)-related bone disease, where impaired osteoblastogenesis promotes osteolytic lesions and creates a permissive bone microenvironment (BME) facilitating malignant plasma cell grow. Early functional and transcriptional remodelling of mesenchymal and osteoblastic cells (OBs) …

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Single Cell Transcriptomics on Bone Marrow Biopsies Unveils Peculiar Bone Microenvironment Cell Subtypes and Highlights Alterations Correlated with High-Risk Features in Precursor Monoclonal Gammopathies and Multiple Myeloma Patients

Mattia Dessena, Tommaso Torelli, Cristina Manferdini, Denise Toscani et autres

Multiple myeloma (MM) can be preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering MM (SMM). In the pathophysiology of MM, the bone microenvironment (BME) plays a pivotal role, but how BME changes contribute to tumor progression in MGUS and SMM …

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P-269 Pygo2 Is Overexpressed in Myeloma Cells With 1q21 Amplification Being Involved in Carfilzomib Resistance

Nicolas Thomas Iannozzi, Paola Storti, Rosanna Vescovini, Valentina Franceschi et autres

Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML

Matteo Marchesini, Andrea Gherli, Elisa Simoncini, Lucas Moron Dalla Tor et autres

The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 abnormalities. By taking advantage of the intersectionality of high-throughput cell-based and gene expression screens selective and pan-histone deacetylase inhibitors (HDACis) …

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Abstract 6848: Analysis of the bone microenvironment cells by single cell transcriptomics reveals altered features in multiple myeloma patients compared to pre-malignant monoclonal gammopathies

Paola Storti, Tommaso Torelli, Cristina Manferdini, Denise Toscani et autres

Abstract Multiple myeloma (MM) is a malignant plasma cell dyscrasia that can be preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering MM (SMM). How the bone microenvironment (BME) changes and contributes to tumoral progression in MM remains unresolved. Published data …

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Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma

Natthakan Thongon, Feiyang Ma, Natalia Baran, Pamela Pennington Lockyer et autres

DNA damage resistance is a major barrier to effective DNA-damaging therapy in multiple myeloma (MM). To discover mechanisms through which MM cells overcome DNA damage, we investigate how MM cells become resistant to antisense oligonucleotide (ASO) therapy targeting Interleukin enhancer binding factor …

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CAD204520 Targets NOTCH1 PEST Domain Mutations in Lymphoproliferative Disorders

Luca Pagliaro, Elisa Cerretani, Anna Montanaro, Lucas Moron Dalla Tor et autres

NOTCH1 PEST domain mutations are often seen in hematopoietic malignancies, including T-cell acute lymphoblastic leukemia (T-ALL), chronic lymphocytic leukemia (CLL), splenic marginal zone lymphoma (SMZL), mantle cell lymphoma (MCL), and diffuse large B-cell lymphoma (DLBCL). These mutations play a key role in …

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CD38 expression by plasma cells in extramedullary multiple myeloma

Laura Notarfranchi, Fabrizio Accardi, Cristina Mancini, Eugenia Marta Martella et autres

Not available.

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