Yam Amir

Licking microstructure behavior classifies a spectrum of emotional states in mice

Randa Salalha, Micky Holzman, Federica Cruciani, Gil Ben David et autres

Measuring precise emotional tagging for taste information, with or without the use of words, is challenging. While affective taste valence and salience are core components of emotional experiences, traditional behavioral assays for taste preference, which often rely on cumulative consumption, lack the …

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High Genetic Diagnostic Yield for Patients with Rare Movement Disorders at a Single‐Center Neurogenetics Clinic

Dvir Penn, Yam Amir, Gil Ben David, Alina Kurolap et autres

BACKGROUND: As advanced molecular testing is incorporated into routine clinical practice, accessibility and yield remain limited. OBJECTIVES: We propose a simplified and effective workup strategy to maximize diagnostic yield based on presented diagnostic yield of rare movement disorders at a tertiary Neurogenetics …

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A computational framework for detecting inter-tissue gene-expression coordination changes with aging

Shaked Briller, Gil Ben David, Yam Amir, Gil Atzmon et autres

Aging is a complex and systematic biological process that involves multiple genes and biological pathways across different tissues. While existing studies focus on tissue-specific aging factors, the inter-tissue interplay between molecular pathways during aging remains insufficiently explored. To bridge this gap, we …

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The d3GHR carrier epigenome in Druze clan longevity

Ghadeer Falah, Alina Kurolap, Tamar Paperna, Nina Ekhilevitch et autres

The Druze are a distinct group known for their close community, traditions, and consanguineous marriages, dating back to the eleventh century. This practice has led to unique genetic variations, impacting both pathology and gene-associated phenotypes. Some Druze clans, particularly those with exceptional …

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National Rapid Genome Sequencing in Neonatal Intensive Care

Daphna Marom, Adi Mory, Sivan Reytan-Miron, Yam Amir et autres

(Abstracted from JAMA Network Open 2024;7(2):e240146 A large portion of mortality in neonatal intensive care units (NICUs) can be attributed to genetic disorders and/or birth defects; often, diagnosis of specific disorders can be difficult due to overlapping symptomology and insufficient sensitivity of …

National Rapid Genome Sequencing in Neonatal Intensive Care

Daphna Marom, Adi Mory, Sivan Reytan-Miron, Yam Amir et autres

Importance: National implementation of rapid trio genome sequencing (rtGS) in a clinical acute setting is essential to ensure advanced and equitable care for ill neonates. Objective: To evaluate the feasibility, diagnostic efficacy, and clinical utility of rtGS in neonatal intensive care units …

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Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis

Hagit Baris Feldman, Chofit Chai Gadot, David Zahler, Adi Mory et autres

Two siblings presented with cardiomyopathy, hypertension, arrhythmia, and fibrosis of the left atrium. Each had a homozygous null variant in CORIN, the gene encoding atrial natriuretic peptide (ANP)–converting enzyme. A plasma sample obtained from one of the siblings had no detectable levels …

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Can Epigenetics Predict Drug Efficiency in Mental Disorders?

Gil Ben David, Yam Amir, Randa Salalha, Lital Sharvit et autres

Psychiatric disorders affect millions of individuals and their families worldwide, and the costs to society are substantial and are expected to rise due to a lack of effective treatments. Personalized medicine-customized treatment tailored to the individual-offers a solution. Although most mental diseases …

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Exposure to Juvenile Stress Induces Epigenetic Alterations in the GABAergic System in Rats

Gil Ben David, Yam Amir, Kuldeep Tripathi, Lital Sharvit et autres

Epigenetics is a gene–environment interaction mechanism, manifested mostly through changes in regulatory gene expression. Stress is an established environmental factor known to induce epigenetic changes. This study aimed to assess the long-term effect of stress as juveniles, or juvenile and adult stress, …

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Dietary Walnuts Preserve Aspects of Health Span and Alter the Hippocampal Lipidome in Aged High-Fat Diet-Fed Mice

Ardijana Novaj, Matthew G. Engel, Ruixuan Wang, Kai Mao et autres

Evidence continues to accrue that aging and its diseases can be delayed by pharmacologic and dietary strategies that target the underlying hallmarks of the aging process. However, identifying simple, safe, and effective dietary strategies involving the incorporation of whole foods that may …

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Senescence and Longevity of Sea Urchins

Yam Amir, Maayan Insler, Abram Giller, Danielle Gutman et autres

Sea urchins are a minor class of marine invertebrates that share genetic similarities with humans. For example, the sea urchin species Strongylocentrotus purpuratus is estimated to have 23,300 genes in which the majority of vertebrate gene families are enveloped. Some of the …

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