David Zahler

Prognostic Value of Right Atrial Strain in Patients With Moderate‐to‐Severe Tricuspid Regurgitation

Roei Merin, Lior Zornitzki, David Zahler, O Shporn et autres

Background Significant tricuspid regurgitation (TR) leads to right ventricular dysfunction and associated comorbidities. As the receiving chamber for regurgitant volume, the right atrium undergoes significant mechanical remodeling. This study investigated whether right atrial reservoir strain (RArS), a key marker of atrial mechanics, …

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Transcatheter Aortic Valve Planar Tilt

Jeremy Ben-Shoshan, Aviel Shetrit, Inbal Greenberg, Maria Gerber et autres

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Rapidly Reversible Precapillary Pulmonary Hypertension in a Patient With Scurvy

Joseph Somech, David Zahler, Raphaël St-Germain, Osama Roshdy et autres

A 22 year old female presented with a rapid clinical deterioration, precapillary pulmonary hypertension (PH), and cardiogenic shock. She received inotropic support and vasodilatory pulmonary arterial hypertension (PAH) therapy. Two hours after the first dose of oral tadalafil, her dyspnea and systemic …

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The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI

Yeela Talmor‐Barkan, Amos Levi, Marco Barbanti, Roberto Valvo et autres

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Transcatheter Aortic Valve Implantation in Small and Very Small Aortic Valve Annuli: A Propensity‐Matched Analysis Between Self‐Expanding Versus Balloon‐Expandable Valves

Tamar Itach, Itamar Loewenstein, David Zahler, Ariel Finkelstein et autres

ABSTRACT Background The management of Transcatheter Aortic Valve Implantation (TAVI) patients with a small aortic annulus (SAA) postures a substantial challenge, increasing the risk of patient‐ prosthesis mismatch (PPM) and overall mortality. Aims This study aimed to compare the hemodynamic and clinical …

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Triggering type and long-term survival following ST segment elevation-myocardial infarction treated with primary percutaneous coronary intervention

Moaad Slieman, Inbal Greenberg, Zach Rozenbaum, Yoav Granot et autres

BACKGROUND: Physical and emotional stress are recognized triggers of acute coronary syndromes, including ST segment elevation-myocardial infarction (STEMI). We have previously shown that identifiable triggers precede symptoms in over one-third of STEMI patients and inversely correlate with the extent of coronary artery …

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Left Atrial Strain in Omicron-Type COVID-19 Patients

Sheizaf Gefen, Aviel Shetrit, Eihab Ghantous, Aviram Hochstadt et autres

Background Information about left atrial (LA) 2-dimensional (2D) strain parameters in patients with the Omicron variant of COVID-19 is limited. The aim of this study is to evaluate LA strain (LAS) in COVID-19 patients with the Omicron variant and compare it to …

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Prognostic value of echocardiographic-derived stroke volume in severe primary mitral regurgitation

Yoav Granot, Sheizaf Gefen, Daniel Karlsberg, Orly Ran Sapir et autres

AIMS: Studies have demonstrated the importance of forward flow, and specifically of stroke volume (SV) and SV index (SVI), as prognostic markers in different cardiovascular diseases. In this study, we aim to evaluate the association between SV and SVI thresholds and prognosis …

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Exercise Limitation in Hypertrophic Cardiomyopathy: Combined Stress Echocardiography and Cardiopulmonary Exercise Test

Yonatan Erez, Eihab Ghantous, Aviel Shetrit, Ryan S Zamanzadeh et autres

AIMS: The study aims to investigate exercise-limiting factors in hypertrophic cardiomyopathy (HCM) using combined stress echocardiography and cardiopulmonary exercise test. METHODS AND RESULTS: A symptom-limited ramp bicycle exercise test was performed in the semi-supine position on a tilting dedicated ergometer. Echocardiographic images …

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Outcomes and predictors of left ventricle recovery in patients with severe left ventricular dysfunction undergoing transcatheter aortic valve implantation

Guy Witberg, Amos Levi, Yeela Talmor‐Barkan, Marco Barbanti et autres

BACKGROUND: Data on the likelihood of left ventricle (LV) recovery in patients with severe LV dysfunction and severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) and its prognostic value are limited. AIMS: We aimed to assess the likelihood of LV recovery …

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Complete loss of the atrial natriuretic peptide‐converting enzyme Corin and CHAF‐LA syndrome: Implications to natriuretic peptide physiology and left atrium health

Alina Kurolap, Chofit Chai Gadot, David Zahler, Jacob N. Ablin et autres

The natriuretic peptide (NP) hormone system has been extensively studied in the context of blood pressure homeostasis and cardiovascular disease. 1 Two main NPs -atrial natriuretic peptide (ANP) and B-type/ brain NP (BNP)are secreted from the left atrial and ventricular cardiomyocytes, respectively, …

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Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis

Hagit Baris Feldman, Chofit Chai Gadot, David Zahler, Adi Mory et autres

Two siblings presented with cardiomyopathy, hypertension, arrhythmia, and fibrosis of the left atrium. Each had a homozygous null variant in CORIN, the gene encoding atrial natriuretic peptide (ANP)–converting enzyme. A plasma sample obtained from one of the siblings had no detectable levels …

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