Federica Cruciani

Licking microstructure behavior classifies a spectrum of emotional states in mice

Randa Salalha, Micky Holzman, Federica Cruciani, Gil Ben David et autres

Measuring precise emotional tagging for taste information, with or without the use of words, is challenging. While affective taste valence and salience are core components of emotional experiences, traditional behavioral assays for taste preference, which often rely on cumulative consumption, lack the …

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Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit

Haneen Kayyal, Federica Cruciani, Sailendrakumar Kolatt Chandran, Efrat Edry et autres

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Intrinsic Excitability in Layer IV–VI Anterior Insula to Basolateral Amygdala Projection Neurons Correlates with the Confidence of Taste Valence Encoding

Sailendrakumar Kolatt Chandran, Adonis Yiannakas, Haneen Kayyal, Randa Salalha et autres

Avoiding potentially harmful, and consuming safe food is crucial for the survival of living organisms. However, the perceived valence of sensory information can change following conflicting experiences. Pleasurability and aversiveness are two crucial parameters defining the perceived valence of a taste and …

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Perturbation of Cortical Excitability in a Conditional Model of PCDH19 Disorder

Didi Lamers, Silvia Landi, Roberta Mezzena, Laura Baroncelli et autres

PCDH19 epilepsy (DEE9) is an X-linked syndrome associated with cognitive and behavioral disturbances. Since heterozygous females are affected, while mutant males are spared, it is likely that DEE9 pathogenesis is related to disturbed cell-to-cell communication associated with mosaicism. However, the effects of …

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Intrinsic excitability in layer IV-VI anterior insula to basolateral amygdala projection neurons encodes the confidence of taste valence

Sailendrakumar Kolatt Chandran, Adonis Yiannakas, Haneen Kayyal, Randa Salalha et autres

Abstract Avoiding potentially harmful, and consuming safe food is crucial for the survival of living organisms. However, sensory information can change its valence following conflicting experiences. Novelty and aversiveness are the two crucial parameters defining the currently perceived valence of taste. Importantly, …

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Perturbation of cortical excitability in a conditional model of PCDH19 disorder

Didi Lamers, Silvia Landi, Roberta Mezzena, Laura Baroncelli et autres

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Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter

Francesco Trovato, Riccardo Parra, Enrico Pracucci, Silvia Landi et autres

Genetic mosaicism, a condition in which an organ includes cells with different genotypes, is frequently present in monogenic diseases of the central nervous system caused by the random inactivation of the X-chromosome, in the case of X-linked pathologies, or by somatic mutations …

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A Cre-amplifier to generate and detect genetic mosaics in vivo

Francesco Trovato, Riccardo Parra, Enrico Pracucci, Silvia Landi et autres

Abstract Cre-Lox manipulation is the gold standard for cell-specific expression or knockout of selected genes. However, it is not unusual to deal with conditions of low Cre expression or transient activation, which can often go undetected by conventional Cre-reporters. We designed Beatrix, …

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