Jean‐Paul Soulillou

Calcification of surgical aortic bioprostheses and its impact on clinical outcome

Guillaume Guimbretière, Thomas Sénage, Anne‐Sophie Boureau, Jean-Charles Roos et autres

AIMS: Aortic valve calcification (AVC) of surgical valve bioprostheses (BPs) has been poorly explored. We aimed to evaluate in vivo and ex vivo BP AVCs and its prognosis value. METHODS AND RESULTS: Between 2011 and 2019, AVC was assessed using in vivo …

fr, es, it, il (code pays fourni par la source)

First-in-human Study With LIS1, a Next-generation Porcine Low Immunogenicity Antilymphocyte Immunoglobulin in Kidney Transplantation

Ondřej Viklický, Janka Slatinská, L Janoušek, Juliette Rousse et autres

BACKGROUND: Polyclonal rabbit antithymocyte globulins (ATGs) are commonly used in organ transplantation as induction. Anti- N -glycolylneuraminic acid carbohydrate antibodies which develop in response to rabbit carbohydrate antigens might lead to unwanted systemic inflammation. LIS1, the first new generation of antilymphocyte globulins …

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Differential Immune Response to Bioprosthetic Heart Valve Tissues in the α1,3Galactosyltransferase-Knockout Mouse Model

Kelly Casós, Roger Llatjós, Arnau Blasco-Lucas, Sebastián G. Kuguel et autres

Structural valve deterioration (SVD) of bioprosthetic heart valves (BHVs) has great clinical and economic consequences. Notably, immunity against BHVs plays a major role in SVD, especially when implanted in young and middle-aged patients. However, the complex pathogenesis of SVD remains to be …

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Aglycosylated extracellular loop of inwardly rectifying potassium channel 4.1 (KCNJ10) provides a target for autoimmune neuroinflammation

Arnaud Nicot, Jean Harb, Alexandra Garcia, Flora Guillot et autres

Abstract Multiple sclerosis is an autoimmune disease of the central nervous system. Yet, the autoimmune targets are still undefined. The extracellular e1 sequence of KCNJ10, the inwardly rectifying potassium channel 4.1, has been subject to fierce debate for its role as a …

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LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation

Juliette Rousse, Pierre‐Joseph Royer, Gwénaëlle Evanno, Elsa Lhériteau et autres

Anti-thymocyte or anti-lymphocyte globulins (ATGs/ALGs) are immunosuppressive drugs used in induction therapies to prevent acute rejection in solid organ transplantation. Because animal-derived, ATGs/ALGs contain highly immunogenic carbohydrate xenoantigens eliciting antibodies that are associated with subclinical inflammatory events, possibly impacting long-term graft survival. …

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Case Report: Long-term observations from the tacrolimus weaning randomized clinical trial depicts the challenging aspects for determination of low-immunological risk patients

Christophe Masset, Jacques Dantal, Jean‐Paul Soulillou, Alexandre Walencik et autres

Whilst calcineurin inhibitors (CNI) are the cornerstone of immunosuppressive maintenance therapy in kidney transplantation, several studies have investigated the safety of CNI withdrawal in order to avoid their numerous side effects. In this context, we performed several years ago a clinical randomized …

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LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation

Juliette Rousse, Pierre‐Joseph Royer, Gwénaëlle Evanno, Elsa Lhériteau et autres

ABSTRACT Anti-thymocyte/lymphocyte globulins (ATGs/ALGs) are immunosuppressive drugs used in induction therapies to prevent acute rejection in solid organ transplantation. Because of animal origin, ATGs/ALGs contain highly immunogenic carbohydrate xenoantigens eliciting antibodies that are associated with subclinical inflammatory events possibly impacting long-term graft …

fr, it (code pays fourni par la source)

Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment

A Gamallo Moure, Sawsen Bekir, Elodie Bacou, Quentin Pruvost et autres

Abstract A bioartificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes therapy. However, the main limitation of this approach is O 2 supply, especially until graft neovascularization. Here, we described a methodology to design an …

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Corrigendum to “Oligoclonal myelin-reactive T-cell infiltrates derived from neuromyelitis optica spectrum disorder (NMOSD) lesions are enriched in Th17 cells” [Clinical Immunology 130 (2009) 133–144]

Monica Montes, Xin Zhang, Laureline Berthelot, David Laplaud et autres

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The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Thomas Sénage, Anu Paul, Thierry Le Tourneau, Imen Fellah‐Hebia et autres

Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve degeneration (SVD) limits their use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly antibodies against the xenoantigens …

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Reader response: Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS

Laureline Berthelot, Ludmilla Le Berre, Jean‐Paul Soulillou

Impact of non-antibiotic drugs on the human intestinal microbiome

Quentin Le Bastard, Laureline Berthelot, Jean‐Paul Soulillou, Emmanuel Montassier

INTRODUCTION: The gut microbiota is composed of trillions of microbial cells and viruses that interact with hosts. The composition of the gut microbiota is influenced by several factors including age, diet, diseases, or medications. The impact of drugs on the microbiota is …

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