Kelly Casós

Antibody and Cellular Immune Responses in Old α1,3-Galactosyltransferase-Knockout Mice Implanted with Bioprosthetic Heart Valve Tissues

Kelly Casós, Roger Llatjos, Arnau Blasco-Lucas, Sebastián G. Kuguel et autres

Structural valve deterioration (SVD) remains a key limitation in bioprosthetic heart valve (BHV) usage influenced by patient age. A deeper understanding of SVD pathogenesis, particularly of the immune-mediated processes altering current BHV materials, is therefore critical. To this end, commercially available BHV …

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Effects of Physical Training on Mitochondrial Dynamic in Pulmonary Arterial Hypertension

Isabel Blanco, Kelly Casós, I. Gómez-Hernández, A. Bosacoma Armora et autres

Abstract RATIONALE Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by increased pulmonary vascular resistance and impaired exercise capacity. While rehabilitation programs have been shown to improve quality of life in PAH patients, the underlying mechanisms remain poorly understood. Exercise …

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Effects of Low-intensity Exercise on Pulmonary Arterial Hypertension: A Comprehensive Transcriptomic Analysis of Lung, Heart and Muscle

Ignacio Blanco, D. Aguilar, Kelly Casós, I. Gómez-Hernández et autres

Abstract Low-intensity training in patients with pulmonary arterial hypertension (PAH) has been shown to improve quality of life, exercise capacity, and hemodynamics. However, the effects vary between individuals by mechanisms that remain poorly understood. In this study, a murine model of PAH, …

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CIRCULACIÓN PULMONAR

I Fernando Blanco, Daniel Aguilar, Kelly Casós, Irene Gómez et autres

Trabajo presentado en el 58° Congreso de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR), celebrado en Bilbao, del 12 al 14 de junio de 2025

Effects of Physical Training on Mitochondrial Function in Pulmonary Arterial Hypertension

Isabel Blanco, Kelly Casós, Itzíar Gómez, Olga Tura-Ceide et autres

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Differential Immune Response to Bioprosthetic Heart Valve Tissues in the α1,3Galactosyltransferase-Knockout Mouse Model

Kelly Casós, Roger Llatjós, Arnau Blasco-Lucas, Sebastián G. Kuguel et autres

Structural valve deterioration (SVD) of bioprosthetic heart valves (BHVs) has great clinical and economic consequences. Notably, immunity against BHVs plays a major role in SVD, especially when implanted in young and middle-aged patients. However, the complex pathogenesis of SVD remains to be …

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Oxidative Stress in Structural Valve Deterioration: A Longitudinal Clinical Study

Manuel Galiñanes, Kelly Casós, Arnau Blasco-Lucas, Eduard Permanyer et autres

The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A) and BHV patients during the …

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Defective dimerization of FoF1‐ATP synthase secondary to glycation favors mitochondrial energy deficiency in cardiomyocytes during aging

Diana Bou‐Teen, Celia Fernández‐Sanz, Elisabet Miró‐Casas, Zuzana Nichtová et autres

Aged cardiomyocytes develop a mismatch between energy demand and supply, the severity of which determines the onset of heart failure, and become prone to undergo cell death. The FoF1-ATP synthase is the molecular machine that provides >90% of the ATP consumed by …

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The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Thomas Sénage, Anu Paul, Thierry Le Tourneau, Imen Fellah‐Hebia et autres

Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve degeneration (SVD) limits their use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly antibodies against the xenoantigens …

fr, us, il, es, it, ca, se, gb (code pays fourni par la source)

Characterization of putative regulatory isoforms of porcine tumor necrosis factor receptor 2 in endothelial cells

Mireia Uribe‐Herranz, Sebastián G. Kuguel, Kelly Casós, Cristina Costa

Tumor necrosis factor α (TNFα) and its receptors contribute to rejection of transplanted cells and organs. To elucidate how TNFα affects xenograft rejection, we previously cloned the cDNA of pig TNF-receptor 2 (pTNFR2) and found four isoforms: one comprising the full receptor …

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Cell-Based Assays for Modeling Xenogeneic Immune Responses

Kelly Casós, Roberta Sommaggio, Magdiel Pérez-Cruz, Cristina Costa

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Determination of Redox Status in Serum

Kelly Casós, Cristina Costa, Manuel Galiñanes

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