Gerd‐Helge Schneider

Generative deep learning reconstructs subcortical neural signals from cortical recordings for closed-loop brain stimulation

Zixiao Yin, Timon Merk, Maria Olaru, Richard M. Köhler et autres

Abstract Closed-loop deep brain stimulation (DBS) relies on continuous neural biomarker sensing, yet clinical utility is often limited by signal dropout, stimulation artifacts, and hardware constraints in subcortical recordings. Here, we develop a deep learning framework combining spectral processing with generative diffusion …

cn, de, us, ch (code pays fourni par la source)

Movement dependent neural substates within levodopa-induced dyskinesia in Parkinson's disease

Jeroen Habets, Timon Merk, Varvara Mathiopoulou, Jonathan Kaplan et autres

Parkinson patients suffer from levodopa-induced dyskinesia, which occur adversely to chronic dopaminergic treatment. These abnormal involuntary movements can only partly be actively suppressed and affect quality of life. A lowered motor inhibition during hyperdopaminergic states, associated with structural and plasticity changes in …

de (code pays fourni par la source)

Identifying maximal beta power from directional subthalamic local field potentials in Parkinson’s disease

Jennifer K. Behnke, Robert Lucien Peach, Moritz Gerster, Richard M. Köhler et autres

Accurate subthalamic beta activity could guide deep brain stimulation programming in Parkinson's disease, but bipolar recordings complicate contact selection. In 39 patients, we validated three methods to estimate pseudo-monopolar beta power. Distance-weighted methods (Euclidean, Strelow) agreed consistently with the externalized "ground-truth" beta …

de, gb (code pays fourni par la source)

Long-term efficiency of pallidal DBS and the role of Levodopa treatment in DYT-GNAL and 18p deletion syndrome associated dystonia: an observational study and review of literature

Johanna M. Reimer, Friederike Schumann, Katja Lohmann, Thomas G. Riemer et autres

Dystonia due to loss-of-function variants in the GNAL gene in DYT-GNAL and 18p-deletion (18pdel) syndrome has been reported to respond well to pallidal deep brain stimulation (GPi-DBS) occasionally, but long-term data is scarce. GNAL is implicated in dopamine receptor function, which may …

de (code pays fourni par la source)

Voxel-based morphometry in Parkinson’s Disease patients with GBA mutation and its predictive role for cognition after STN-DBS

Johanna M. Reimer, Friederike Schumann, Doreen Gruber, Gerd‐Helge Schneider et autres

The deep brain stimulation response network in Parkinson’s disease operates in the high beta band

Bahne H. Bahners, Lukas L. Goede, Patricia Zvarova, Garance M. Meyer et autres

Deep brain stimulation (DBS) of the subthalamic nucleus improves motor symptoms in patients with Parkinson's disease. Using functional MRI, optimal DBS response networks have been characterized. However, neural activity associated with Parkinsonian symptoms is magnitudes faster than what can be resolved by …

de, us (code pays fourni par la source)

Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity–a cross-sectional multicentre study

Moritz Gerster, Gunnar Waterstraat, Thomas S. Binns, Natasha Darcy et autres

Background Parkinson's disease is linked to increased beta rhythms (13–30 Hz) in the subthalamic nucleus, which correlate with motor symptoms. However, findings across studies are inconsistent. Furthermore, the contribution of other frequencies to symptom severity remains underexplored. Methods We analysed subthalamic local …

de, gb, fr (code pays fourni par la source)

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants

Timon Merk, Richard M. Köhler, Toni M. Brotons, Samed Rouven Vossberg et autres

Brain-computer interface research can inspire closed-loop neuromodulation therapies, promising spatiotemporal precision for the treatment of brain disorders. Decoding dynamic patient states from brain signals with machine learning is required to leverage this precision, but a standardized framework for invasive brain signal decoding …

us, de, ar, cn (code pays fourni par la source)

Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease

Alessia Cavallo, Richard M. Köhler, Johannes Leon Busch, Jeroen Habets et autres

Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson's disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic stimulation in mice, we hypothesized that STN-DBS can mimic dopaminergic reinforcement of ongoing movement kinematics …

de, us, gb (code pays fourni par la source)

Predicting cognition after subthalamic Deep Brain Stimulation in Parkinson’s Disease

Dorothee Kübler, Heiner Stuke, Melanie Astalosch, Luísa Martins Ribeiro et autres

Cognitive deficits have a high impact on quality of life in Parkinson's disease (PD). This study takes into account the multifaceted etiology of cognition to estimate the cognitive outcome after deep brain stimulation (DBS) surgery in PD. Clinical, neuropsychological, perioperative, neuroimaging- and …

de (code pays fourni par la source)

Electrophysiological changes in the acute phase after deep brain stimulation surgery

Lucia K. Feldmann, Diogo Coutinho Soriano, Jeroen Habets, Valentina D’Onofrio et autres

BACKGROUND: With the introduction of sensing-enabled deep brain stimulation devices, characterization of long-term biomarker dynamics is of growing importance for treatment optimization. The microlesion effect is a well-known phenomenon of transient clinical improvement in the acute post-operative phase. While beta band activity …

de, br, it, gb (code pays fourni par la source)

The Risk of Bacterial Colonization Increases With Multiple Replacements of Implanted Pulse Generators for Deep Brain Stimulation

David Wasilewski, Ada Marie Hoffmann, Franziska M. Braun, Seyran Bozkurt et autres

OBJECTIVES: Deep brain stimulation (DBS) has revolutionized the treatment of movement disorders, yet repeated implanted pulse generator (IPG) replacements due to battery depletion pose a risk for surgical site infections. This study investigates microbial colonization dynamics across consecutive IPG replacements and compares …

de (code pays fourni par la source)