Movement dependent neural substates within levodopa-induced dyskinesia in Parkinson's disease
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Le résumé fourni par la source
Parkinson patients suffer from levodopa-induced dyskinesia, which occur adversely to chronic dopaminergic treatment. These abnormal involuntary movements can only partly be actively suppressed and affect quality of life. A lowered motor inhibition during hyperdopaminergic states, associated with structural and plasticity changes in the cortico-basal-ganglia motor network, is hypothesized to enable dyskinesia. Multiple oscillatory cortico-subthalamic patterns associated with dyskinesia have been described but their dependence on behavioral states such as movement presence remains unknown, which is crucial for its use in real-life application of adaptive neuromodulation. We studied invasive cortico-subthalamic oscillations in 22 patients with Parkinson's disease during dyskinesia-evoking protocols. Clinical assessments differentiated between non-dyskinetic and dyskinetic periods, and kinematic monitoring detected movement presence, leading to four behavioral states containing rest, voluntary movements, movement suppression during dyskinesia, and dyskinetic movements. Data-driven methods reduced data dimensionalities and optimized frequency-specific signal-to-noise ratios in the neural recordings and allowed feature extraction of spectral magnitudes, variances, and inter-subthalamic and cortico-subthalamic coherences. Subthalamic theta-activity and attenuated beta-activity were elevated during both dyskinetic movement suppression and execution, while cortico-subthalamic gamma-activity was only increased during dyskinetic movement execution. The subthalamic oscillations predicted dyskinesia presence, but varying behavioral states containing fluctuating movement presence affected the predictive performance. Movement-aware classifications improved dyskinesia detection based on cortical and on gamma oscillations. Introducing a movement-aware classification which considered the current behavioral state improved the neural detection of therapeutic states. We propose movement execution during dyskinesia should be considered as a distinct behavioral and neural microstate within a dopamine-depending hyperdopaminergic macrostate. Integrating this state concept may inform future adaptive neuromodulation and enhance its naturalistic robustness during every-day life.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Movement dependent neural substates within levodopa-induced dyskinesia in Parkinson's disease
- Date Crossref
- 31/07/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Berlin Institute of Health at Charité - Universitätsmedizin Berlin pays non établi dans la noticeStructure de recherche
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Charité - Universitätsmedizin Berlin pays non établi dans la noticeÉtablissement de santé
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Bernstein Center for Computational Neuroscience Berlin pays non établi dans la noticeOrganisme public
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Einstein Center for Neurosciences Berlin pays non établi dans la noticeStructure de recherche
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University of Würzburg pays non établi dans la noticeUniversité ou école supérieure
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European Neuroendocrine Tumor Society pays non établi dans la noticeInstitution
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Universitätsklinikum Würzburg pays non établi dans la noticeÉtablissement de santé
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Humboldt-Universität zu Berlin pays non établi dans la noticeUniversité ou école supérieure
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Berlin Institute of Health (BIH) pays non établi dans la noticeStructure de recherche
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Movement Disorders and Neuromodulation Unit pays non établi dans la noticeInstitution
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Department of Neurosurgery pays non établi dans la noticeInstitution
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Institute of Clinical Neurobiology pays non établi dans la noticeStructure de recherche
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charité - Universitätsmedizin Berlin et Bernstein Center for Computational Neuroscience Berlin, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.