The deep brain stimulation response network in Parkinson’s disease operates in the high beta band
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Le résumé fourni par la source
Deep brain stimulation (DBS) of the subthalamic nucleus improves motor symptoms in patients with Parkinson's disease. Using functional MRI, optimal DBS response networks have been characterized. However, neural activity associated with Parkinsonian symptoms is magnitudes faster than what can be resolved by this method. Although both spatial and temporal domains of these networks appear crucial, no single study has yet investigated both domains simultaneously. Here, we aimed at closing this gap by analysing electrophysiological data from a total of n = 127 hemispheres. Using subthalamic local field potentials that were recorded concurrently alongside whole-brain magnetoencephalography in a multi-centre cohort of patients who underwent subthalamic DBS for the treatment of Parkinson's disease (n = 100 hemispheres), we analysed the DBS response network in both spatial and temporal domains. In every cortical vertex, cortico-subthalamic coupling was correlated with stimulation outcomes. This network spatially resembled functional MRI-based findings (R = 0.40, P = 0.039) and explained significant amounts of variance in clinical outcomes (βstd = 0.30, P = 0.002), whereas theta-alpha and low beta coupling did not show significant associations with DBS response (theta-alpha: βstd = -0.02, P = 0.805; low beta: βstd = -0.08, P = 0.426). The 'optimal' high beta coupling map was robust when subjected to various cross-validation designs (10-fold cross-validation: R = 0.29, P = 0.009; split-half design: R = 0.31, P = 0.026) and was able to predict outcomes across DBS centres [R = 0.74; P(1) = 8.9 × 10-5]. We identified a DBS response network that resembles the previously defined MRI network and operates in the high beta band. Maximal connectivity to this network was associated with optimal DBS outcomes and was able to cross-predict clinical improvements across DBS surgeons and centres.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The deep brain stimulation response network in Parkinson’s disease operates in the high beta band
- Date Crossref
- 06/02/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Düsseldorf University Hospital pays non établi dans la noticeÉtablissement de santé
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Circuit Therapeutics (United States) pays non établi dans la noticeEntreprise
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Heinrich Heine University Düsseldorf pays non établi dans la noticeUniversité ou école supérieure
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Humboldt-Universität zu Berlin pays non établi dans la noticeUniversité ou école supérieure
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Berlin Institute of Health at Charité - Universitätsmedizin Berlin pays non établi dans la noticeStructure de recherche
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Massachusetts General Hospital Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
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Physikalisch-Technische Bundesanstalt pays non établi dans la noticeOrganisme public
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Mayo Clinic Department of Physiology and Biomedical Engineering pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic in Arizona pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic in Florida pays non établi dans la noticeÉtablissement de santé
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German Center for Neurodegenerative Diseases pays non établi dans la noticeStructure de recherche
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NeuroCure Cluster of Excellence pays non établi dans la noticeStructure de recherche
Düsseldorf University Hospital, Circuit Therapeutics (United States) et Heinrich Heine University Düsseldorf, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.