Yuqing Wu

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang et autres

OBJECTIVE: As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC). METHODS: …

cn (code pays fourni par la source)

Prognostic value of ultrasound Breast Imaging Reporting and Data System for disease-free survival in early-stage breast cancer: a retrospective study (2011–2018)

Zhanping You, Ruoqing Hou, Rui Zhang, Meidi Zhang et autres

Background: The Breast Imaging Reporting and Data System (BI-RADS) offers a standardized diagnostic risk stratification framework for assessing breast lesions. However, whether the imaging phenotype captured by the preoperative ultrasound (US) BI-RADS category is associated with long-term survival in early-stage breast cancer …

cn (code pays fourni par la source)

Machine learning–driven identification and experimental validation of key biomarkers in the bile acid metabolic pathway associated with ulcerative colitis

Yuqing Wu, Danyang Gu, Jin Liu, Yongbing Yang et autres

Background: Bile acids are shown to participate in inflammatory responses. This study was designed to investigate the functions of bile acid metabolism-associated genes (BAMGs) in ulcerative colitis (UC), identify the potential biomarkers based on eleven machine learning algorithms. Methods: Seven independent UC …

cn (code pays fourni par la source)

Aggregation-induced dual-emission carbon dots for visual discrimination of methanol from ethanol

Hui-Shuang Li, Cheng-Feng Zhang, Lijia Liu, Hongwei Li et autres

cn (code pays fourni par la source)

Conjugated fullerene C60 networks: From bonding motifs to multifunctional properties

Yinglong Hu, Chao Wang, Yue Zhu, Yuqing Wu et autres

Conjugated fullerene C60 networks, formed through inter-cage covalent bonding, constitute a versatile carbon platform in which bonding configuration, topology, and dimensionality can be engineered to realize a broad spectrum of multifunctional properties. This review surveys recent progress in two-dimensional covalently bonded, conjugated …

cn (code pays fourni par la source)

Citywide metagenomics reveals microbial community and resistome dynamics in urban wastewater

Zhiying Xu, Jiabao Xing, X Y Zeng, Yuqing Wu et autres

Urban wastewater systems connect hospitals, residential communities, transport hubs, and wastewater treatment plants, creating opportunities for the dissemination of microorganisms and antibiotic resistance genes (ARGs). Here, we conduct a three-month, citywide metagenomic survey of wastewater in Xiamen, China, comprising 252 samples from …

cn (code pays fourni par la source)

Acute kidney injury following household pyrethroid aerosol insecticide exposure: a case report and literature review

Yuxin Tang, Yuqing Wu, Xuhang Xue, Sihan Tao et autres

Background: Pyrethroids (PYRs) are increasingly detected in both environmental matrices and human populations. Emerging evidence underscores their potential for systemic toxicity. Biopsy-confirmed nephrotoxicity in humans remains sparsely documented, particularly in non-occupational exposure. We present a case of acute kidney injury (AKI) associated …

cn (code pays fourni par la source)

Astragalus membranaceus and Salvia miltiorrhiza Inhibit Tryptase/PAR2-Mediated Mast Cells – Peritoneal Mesothelial Cells Crosstalk to Ameliorate Peritoneal Fibrosis

Yanlin Chen, Yuqing Wu, Chenghua Zhang, Yuxin Tang et autres

Yanlin Chen,1,2 Yuqing Wu,1,2 Chenghua Zhang,3 Yuxin Tang,1,2 Weiwei Zhu,1 Wei Li,1,2 Kun Gao,1,4 Enchao Zhou,1,2,4 Xufang Wang1,4 1Department of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Department of Clinical Medicine, The First School …

Astragalus membranaceus and Salvia miltiorrhiza Inhibit Tryptase/PAR2-Mediated Mast Cells – Peritoneal Mesothelial Cells Crosstalk to Ameliorate Peritoneal Fibrosis

Yanlin Chen, Yuqing Wu, Chenghua Zhang, Yuxin Tang et autres

Purpose: Mast cells (MCs) act as sentinels of the immune system and are involved in peritoneal fibrosis (PF), but the precise mechanism remains unclear. To investigate this, we focused on Astragalus membranaceus and Salvia miltiorrhiza (AS), a combination known for its anti-inflammatory …

cn (code pays fourni par la source)

Enhanced Thermostability and Ligand Binding Affinity of an Improved Homo sapiens Chondroitin 6-O-Sulfotransferase for Chondroitin Sulfate C Synthesis by Deleting a Dynamic Surface Loop

Lu Wang, Jiajun Huang, Yuqing Wu, Yi-Xiang Wang et autres

) toward PAPS and chondroitin increased by 1.4-fold and 1.9-fold, respectively. Molecular simulation suggested stronger ligand binding, with ΔGbind decreasing from -24.47 kcal/mol to -40.1 kcal/mol. Consequently, the CSC conversion rate increased from 41.2% to 78.4%.

cn (code pays fourni par la source)

Molecular mechanisms of pyrethroid insecticide-induced acute kidney injury: a network toxicology and molecular docking analysis

Xuhang Xue, Yuqing Wu, Pei Sheng, Lianyi Geng et autres

Pyrethroid insecticides are widely used globally, but their potential nephrotoxicity has gained increasing attention. Although previous studies suggest pyrethroids may induce acute kidney injury (AKI), the underlying mechanisms remain unclear. This study employed a network toxicology approach to elucidate the molecular mechanisms …

cn (code pays fourni par la source)

Cellular landscape and diagnostic value of TROP2 in cerebrospinal fluid of lung adenocarcinoma leptomeningeal metastases

Zhe Wang, Jie Luo, Yuexinzi Jin, Ting Wang et autres

Lung adenocarcinoma (LUAD)-derived leptomeningeal metastases (LM) represent a predominant subtype among all LM cases. Nevertheless, the cerebrospinal fluid (CSF) profile of LUAD-LM patients remains poorly characterized and reliable CSF diagnostic biomarkers for LUAD-LM have yet to be established. Using single-cell RNA sequencing …

cn (code pays fourni par la source)