Haoyu Ruan

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang et autres

OBJECTIVE: As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC). METHODS: …

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Construction of a Nomogram Prediction Model for Mortality Risk Within 14 Days in Patients with Acute Myocardial Infarction and Ventricular Septal Rupture

Jie Luo, Ben Xiong Huang, Haoyu Ruan, Du‐Jiang Xie et autres

Objective: This study aimed to develop a nomogram prediction model for predicting 14-day in-hospital mortality in patients with acute myocardial infarction (AMI) and ventricular septal rupture (VSR). Methods: Clinical data of 86 hospitalized patients (44 survivors and 42 non-survivors within 14 days) …

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Cellular landscape and diagnostic value of TROP2 in cerebrospinal fluid of lung adenocarcinoma leptomeningeal metastases

Zhe Wang, Jie Luo, Yuexinzi Jin, Ting Wang et autres

Lung adenocarcinoma (LUAD)-derived leptomeningeal metastases (LM) represent a predominant subtype among all LM cases. Nevertheless, the cerebrospinal fluid (CSF) profile of LUAD-LM patients remains poorly characterized and reliable CSF diagnostic biomarkers for LUAD-LM have yet to be established. Using single-cell RNA sequencing …

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Diagnostic value of CEACAM6 and HE4 in pleural fluid for malignant pleural effusion

Li-Yuan Lin, Shengrui Yang, Mu Yuan, Lixia Zhang et autres

Objective This study aimed to assess the diagnostic performance of carcinoembryonic antigen-related adhesion molecule 6 (CEACAM6) and human epididymis protein 4 (HE4) in pleural fluid for the detection of malignant pleural effusion (MPE).Materials and methods In this prospective study, pleural levels of …

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A Risk Model for 28-Day in-Hospital Mortality in 173 COVID-19 Patients Admission to ICU: A Retrospective Study

Yiting Hua, Yutong Zhou, Ziyue Qin, Yuan Mu et autres

Background: The surge in the number of patients diagnosed with COVID-19 since China's open-door policy has placed a huge burden on the public healthcare system, especially the intensive care system. This study's objective was to discover possible clinical outcome predictors in COVID-19 …

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Diagnostic value of cerebrospinal fluid human epididymis protein 4 for leptomeningeal metastasis in lung adenocarcinoma

Xiangyu Li, Kun Chen, Jie Li, Xuemei Tang et autres

Background: The diagnosis of lung adenocarcinoma (LUAD) leptomeningeal metastasis (LM) remains a clinical challenge. Human epididymis protein 4 (HE4) functions as a novel tumor biomarker for cancers. This study aimed to assess the diagnostic value of cerebrospinal fluid (CSF) HE4, and combined …

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The characteristics of cerebrospinal fluid tumor microenvironment in a patient with leptomeningeal metastases from cancer of unknown primary

Haoyu Ruan, Zhe Wang, Xuemei Tang, Qiong Zhan et autres

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The characteristics of cerebrospinal fluid anaplastic large cells in a patient with primary leptomeningeal anaplastic large cell lymphoma

Haoyu Ruan, Zhe Wang, Kun Chen, Xuemei Tang et autres

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CEACAM6 serves as a biomarker for leptomeningeal metastasis in lung adenocarcinoma

Xueying Wang, Xuemei Tang, Jiahui Gu, Ziwei Sun et autres

BACKGROUND AND AIMS: Diagnosis of leptomeningeal metastasis (LM) is challenging. In our previous study, CEACAM6 mRNA was found to be highly expressed in the circulating tumor cells of cerebrospinal fluid (CSF) from patients with lung adenocarcinoma with LM (LUAD-LM). The aim of …

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Single‐cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases

Haoyu Ruan, Zhe Wang, Ziwei Sun, Jia Wei et autres

Leptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single-cell level. Based on the 10× genomics single-cell …

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Single-cell transcriptome analysis of diffuse large B cells in cerebrospinal fluid of central nervous system lymphoma

Haoyu Ruan, Zhe Wang, Yue Zhai, Ying Xu et autres

Diffuse large B cells in the cerebrospinal fluid (CSF-DLBCs) have offered great promise for the diagnostics and therapeutics of central nervous system lymphoma (CNSL) leptomeningeal involvement. To explore the phenotypic states of CSF-DLBCs, we analyzed the transcriptomes of more than one thousand …

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lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression

Xuemei Tang, Haoyu Ruan, Liu Dong, Sihan Li et autres

lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified GAU1 as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ranking percentile = 99.75 %, P < 10 …

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