Sarah Nietzer

An intestinal matrix-based human lung cancer model reflects clinical data from gefitinib on dosage-dependent efficacy

Elena Johanna Weigl, Thorsten Walles, Sarah Nietzer, Gudrun Dandekar et autres

Lung cancer is the leading cause for cancer related death worldwide. One treatment option for patients with pulmonary adenocarcinoma is the targeted therapy gefitinib (Iressa®, ZD1839). As with other promising targeted therapies, desired in vivo effects of gefitinib came short to in …

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A fully human In-vitro model for bone metastasis: potential of an electrospun scaffold as alternative to biological materials for osteoblast/osteoclast differentiation

J. Nieves, Sarah Nietzer, Tobias Weigel, Lisa Bauer et autres

The development of bone metastases poses a clinical challenge for patients with malignancies originating from diverse organs, including the lungs, prostate, and breast. These metastatic events correlate with a poorer prognosis, and treatments are predominantly palliative. Furthermore, traditional in-vivo models for bone …

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TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1

Christina Funk, Nadja Uhlig, Zsolt Ruzsics, Florentin Baur et autres

Viruses are able to efficiently penetrate cells, multiply and eventually kill infected cells, release tumor antigens and activate the immune system. Therefore, viruses are highly attractive novel agents for cancer therapy. Clinical trials with first generations of oncolytic viruses (OVs) are very …

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EMT, Stemness, and Drug Resistance in Biological Context: A 3D Tumor Tissue/In Silico Platform for Analysis of Combinatorial Treatment in NSCLC with Aggressive KRAS-Biomarker Signatures

Matthias Peindl, Claudia Göttlich, Samantha A. W. Crouch, Niklas Hoff et autres

Epithelial-to-mesenchymal transition (EMT) is discussed to be centrally involved in invasion, stemness, and drug resistance. Experimental models to evaluate this process in its biological complexity are limited. To shed light on EMT impact and test drug response more reliably, we use a …

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Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer

Tanja Nadine Stüber, Razieh Monjezi, Lars Wallstabe, Johanna Kühnemundt et autres

Background Immunotherapy with chimeric antigen receptor (CAR)-engineered T-cells is effective in some hematologic tumors. In solid tumors, however, sustained antitumor responses after CAR T-cell therapy remain to be demonstrated both in the pre-clinical and clinical setting. A perceived barrier to the efficacy …

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3D in vitro test system for vestibular schwannoma

Maria Breun, Donato Daniel Martellotta, Anna Leberle, Sarah Nietzer et autres

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Connecting Cancer Pathways to Tumor Engines: A Stratification Tool for Colorectal Cancer Combining Human In Vitro Tissue Models with Boolean In Silico Models

Florentin Baur, Sarah Nietzer, Meik Kunz, Fabian Saal et autres

To improve and focus preclinical testing, we combine tumor models based on a decellularized tissue matrix with bioinformatics to stratify tumors according to stage-specific mutations that are linked to central cancer pathways. We generated tissue models with BRAF-mutant colorectal cancer (CRC) cells …

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Investigation on Ciliary Functionality of Different Airway Epithelial Cell Lines in Three-Dimensional Cell Culture

Nina Lodes, Katharina Seidensticker, Alexander Perniss, Sarah Nietzer et autres

Three-dimensional respiratory tissue models have been generated using, for example, human primary airway epithelial cells (hAEC) or respective cell lines. To investigate ciliopathies, such as primary ciliary dyskinesia, the presence of functional kinocilia in vitro is an essential prerequisite. Since access to …

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ROR1-CAR T cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models

Lars Wallstabe, Claudia Göttlich, Lena C. Nelke, Johanna Kühnemundt et autres

Solid tumors impose immunologic and physical barriers to the efficacy of chimeric antigen receptor (CAR) T cell therapy that are not reflected in conventional preclinical testing against singularized tumor cells in 2-dimensional culture. Here, we established microphysiologic three-dimensional (3D) lung and breast …

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Development of PDAC organoids on decellularized extracellular matrices

Ezekiel R. Rozmus, Anika Langer, Elvira García de Jalón Viñegra, Gudrun Dandekar et autres

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Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and evaluation in 2D and 3D in vitro models

Michael M. Lübtow, Lena C. Nelke, Julia Seifert, Johanna Kühnemundt et autres

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In silico signaling modeling to understand cancer pathways and treatment responses

Meik Kunz, Julian Jeromin, Maximilian M. Fuchs, Jan Christoph et autres

Precision medicine has changed thinking in cancer therapy, highlighting a better understanding of the individual clinical interventions. But what role do the drivers and pathways identified from pan-cancer genome analysis play in the tumor? In this letter, we will highlight the importance …

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