Georgina Casanovas

Effect of perioperative magnesium sulfate on neurological outcome in neurosurgical patients: a randomized double-blind controlled trial

Isabel Gracia, Neus Fàbregas, Paola Hurtado, Nicolás de Riva et autres

BACKGROUND: Supplemental magnesium sulfate has a potential neuroprotective role in acute brain injury. It is safe, widely available, and inexpensive. This study evaluated the effect of perioperative intravenous administration of magnesium sulfate on brain damage caused by neurosurgery. METHODS: Prospective randomized double-blind …

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Pre-emptive TIPS in high-risk acute variceal bleeding. An updated and revised individual patient data meta-analysis

Oana Nicoară-Farcău, Guohong Han, Marika Rudler, Debora Angrisani et autres

BACKGROUND AND AIMS: A previous individual patient data meta-analysis (IPD-MA) showed that compared with drugs+endoscopy, the placement of transjugular portosystemic shunt within 72 hours of admission (pre-emptive transjugular intrahepatic portosystemic shunt: p-TIPS) increases the survival of high-risk patients (Child-Pugh B+ active bleeding …

ro, nl, es, cn, fr, ch, gb (code pays fourni par la source)

Simvastatin plus Rifaximin to prevent ACLF in patients with decompensated cirrhosis. A randomised, double-blind, placebo-controlled, phase-3 trial: the liverhope efficacy trial

Elisa Pose, César Jiménez, Giacomo Zaccherini, Daniela Campion et autres

Rivaroxaban improves survival and decompensation in cirrhotic patients with moderate liver dysfunction. Double-blind, placebo-controlled trial

Ángela Puente Sánchez, Fanny Turón, Javier Marco Martínez, José Ignacio Fortea et autres

FRAGILE-COLCOVID19: A Clinical Trial Based on Early Administration of an Oral Combination of Colchicine and Prednisone in Elderly Patients with COVID-19 in Geriatric Facilities

José Hernández‐Rodríguez, Julio Durán-Sanclemente, Olga M. O. Araújo, Georgina Casanovas et autres

BACKGROUND: Unprotected and fragile elderly people in nursing homes experienced the highest mortality rates during the initial coronavirus disease 2019 (COVID-19) pandemic. OBJECTIVE: Our aim was to study the role of two oral anti-inflammatory drugs, colchicine and prednisone, in elderly patients with …

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Hepatic encephalopathy is not a contraindication to pre-emptive TIPS in high-risk patients with cirrhosis with variceal bleeding

Marika Rudler, Virginia Hernández–Gea, Bogdan Procopeț, Álvaro Giráldez Gallego et autres

BACKGROUND: A pre-emptive transjugular intrahepatic portosystemic shunt (pTIPS) reduces mortality in high-risk patients with cirrhosis (Child-Pugh C/B+active bleeding) with acute variceal bleeding (AVB). Real-life studies point out that <15% of patients eligible for pTIPS ultimately undergo transjugular intrahepatic portosystemic shunt (TIPS) due …

fr, es, ro, it, de, dk, be, pt, at, ca, ch (code pays fourni par la source)

Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trial

Alvar G.N. Agustí, Gastón De Stéfano, Alberto Levi, Xavier Muñoz et autres

SARS-CoV-2 vaccines have been extremely effective in reducing the incidence of severe coronavirus disease 2019 (COVID-19) [1, 2], but effective and safe treatments for acute infection are still limited [3, 4]. An uncontrolled pulmonary inflammatory response to SARS-CoV-2 is considered a key …

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Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors

Núria Carreras‐Dieguez, Ariel Gustavo Glickman, Meritxell Munmany, Georgina Casanovas et autres

(1) OBJECTIVE: To assess the performance of CA125, HE4, ROMA index and CPH-I index to preoperatively identify epithelial ovarian cancer (EOC) or metastatic cancer in the ovary (MCO). (2) METHODS: single center retrospective study, including women with a diagnosis of adnexal mass. …

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Risk of non‐tumoural portal vein thrombosis in patients with HCV‐induced cirrhosis after sustained virological response

Mattias Mandorfer, Fanny Turón, Sabela Lens, Anna Baiges et autres

BACKGROUND & AIMS: Sustained virological response (SVR) to direct-acting antivirals ameliorates portal hypertension, improves hepatic function and may reverse the procoagulant state observed in patients with cirrhosis. However, an unexpected incidence of portal vein thrombosis (PVT) immediately after antiviral therapy has recently …

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Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data

Oana Nicoară-Farcău, Guohong Han, Marika Rudler, Debora Angrisani et autres

ro, es, cn, fr, ch, nl, be, de, it, dk, pt, at (code pays fourni par la source)

Early-tips should be performed in high-risk cirrhotic patients despite the presence of hepatic encephalopathy at admission

Marika Rudler, Virginia Hernández–Gea, Bogdan Procopeț, Álvaro Giráldez-Gallego et autres

Pre-emptive (early) transjugular intrahepatic porto-systemic shunt in the treatment of high-risk acute variceal bleeding. An individual patient data meta-analysis

Juan Carlos García‐Pagán, Oana Nicoară-Farcău, Debora Angrisani, Alberto Monescillo et autres