Accès ouvert
2026
preprint
OpenAlex
Peter B. Barr, Megan Cooke, Sally I‐Chun Kuo, Henri M. Garrison‐Desany et autres
Abstract Gradients across socioeconomic status (SES) exist across most health conditions. While there has been significant attention devoted to the relationship between SES and physical and mental health, less research has examined how these relate to substance use disorders (SUD). In the …
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Accès ouvert
2026
article
OpenAlex
Sally I‐Chun Kuo, Vivia V. McCutcheon, Fazil Aliev, Kathleen Bucholz et autres
ABSTRACT Background The field's conventional understanding of how genetic factors impact risk for alcohol use disorder (AUD) typically focuses on direct genetic effects, or how an individual's own genetic predispositions are associated with the likelihood of experiencing clinically significant alcohol problems. More …
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Accès ouvert
2026
article
OpenAlex
Megan Cooke, Erin Lumpe, Mallory Stephenson, Sally I‐Chun Kuo et autres
ABSTRACT Background The goal of this paper is to identify environmental, behavioral, and genetic predictors and early midlife correlates of problematic alcohol Use ( PAU ) patterns from adolescence to early midlife. Methods The data are from 1463 twin individuals (60.5% female) …
us, fi
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Accès ouvert
2026
preprint
OpenAlex
Sally I‐Chun Kuo, Jiawen Zhao, Kathleen Bucholz, Christina Elizabeth Garasky et autres
Background. We tested whether parental remission from alcohol use disorder (AUD) would attenuate associations between offspring polygenic predispositions and alcohol milestones from initiation to AUD. Methods. Participants were 2,971 individuals from the Collaborative Study on the Genetics of Alcoholism Prospective Sample. Outcomes …
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2026
preprint
OpenAlex
Maia Choi, Leigh Lustig, Sally I‐Chun Kuo, Holly Poore et autres
AbstractBackgroundFamily environment plays an important role in the development of mental health problems in late childhood and adolescence. Environmental processes such as parenting practices and family conflict have been identified as moderating genetic propensity for the development of both externalizing and internalizing …
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2026
article
OpenAlex
Chloe J. Walker, Chelsea Derlan Williams, Arlenis Santana, Eryn N. DeLaney et autres
Abstract Excessive alcohol use is associated with adverse outcomes, underscoring the importance of identifying factors that may reduce alcohol use among diverse emerging adults, including ethnic-racial identity (ERI) and family factors. Limited work has examined factors that moderate the relations between ERI …
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2026
article
OpenAlex
Megan Cooke, Sally I‐Chun Kuo, Erin Lumpe, Fazil Alıev et autres
Abstract Background Romantic relationships are important contexts for substance use and emotional well-being. We tested the hypotheses that (i) genetic predispositions for alcohol consumption would be positively associated with partner substance use, (ii) partner substance use would moderate genetic influences on one’s …
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Accès ouvert
2025
article
OpenAlex
Maia Choi, Genevieve F. Dash, Sally I‐Chun Kuo, Fazil Alıev et autres
Conduct problems (CPs), including aggression, antisocial behavior, and rule-breaking, emerge in childhood and adolescence. Evidence from twin studies shows that CPs are heritable, with approximately 50% of the variance accounted for by genetic influences. Parenting is one prominent and, importantly, modifiable environmental …
us, nl
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Accès ouvert
2025
article
OpenAlex
Maia Choi, Fazil Alıev, Peter B. Barr, Megan Cooke et autres
Alcohol use during adolescence poses a significant public health problem due to its potential long-term consequences on both physical and mental health and increased risk for developing substance use disorders later in life. Both individual (e.g., genetic liability, neural functioning, personality features) …
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2025
article
OpenAlex
Sally I‐Chun Kuo, Vivia V. McCutcheon, Kathleen K. Bucholz, Danielle M. Dick et autres
Objective Parental separation and relationship discord are linked to alcohol use behaviors, but their influence on the longitudinal course of alcohol misuse and interactions with genetic predisposition remain unclear. This study examined how the longitudinal course of heavy episodic drinking (HED) from …
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Accès ouvert
2025
preprint
OpenAlex
Vivia McCutcheon, Christina Elizabeth Garasky, Jessica E Salvatore, Sally I‐Chun Kuo et autres
This study aims to examine the course of alcohol use, AUD and remission over time and associations of course with parenthood, education, and employment while accounting for individual differences. By analyzing these factors, the study seeks to identify key predictors of remission …
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Accès ouvert
2025
preprint
OpenAlex
Vivia McCutcheon, Christina Elizabeth Garasky, Fanghong Dong, Jessica E Salvatore et autres
Studies that have modeled parental recovery from alcohol use disorder (AUD) have generally found that adolescent offspring of recovered parents had reduced risk for early drinking and behavioral problems relative to their counterparts whose parents had unremitted AUD. Few such studies have …
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