Jee Eun Choi

The suppressive function of ILC2 cells is regulated by β2-adrenergic receptor signaling in breast cancer

Jee Eun Choi, Qi Yan, Jianmin Wang, Nicholas J. Salgia et autres

Type II innate lymphoid cells (ILC2s) have been implicated in both tumor-promoting and tumor-suppressive functions, but the mechanism(s) underlying this functional heterogeneity is not clear. Here, we tested the hypothesis that signaling through β2-adrenergic receptor (β2-AR) drives the pro-tumor functions of ILC2s …

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6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-associated monocytic suppressor cells

Saeed Daneshmandi, Qi Yan, Eduardo Cortes Gomez, Jee Eun Choi et autres

The mechanisms underlying the metabolic adaptation of myeloid cells within the tumor microenvironment remain incompletely understood. Here, we identify 6-phosphogluconate dehydrogenase (6PGD), a rate-limiting enzyme in the pentose phosphate pathway (PPP), as an important regulator of monocytic-myeloid derived suppressor cell (M-MDSC) function. …

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Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism

Saeed Daneshmandi, Eun‐A Ko, Yan Qi, Jee Eun Choi et autres

Glycolysis fuels cytotoxic allogeneic T cells in acute graft-versus-host disease (aGvHD), but the downstream role of glucose metabolism in modulating aGvHD remains unclear. Targeting glycolysis or glucose receptors is toxic. Therefore, we explored alternative glucose-dependent pathways, focusing on the pentose phosphate pathway …

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Deciphering neutrophil dynamics in the focal lesion tumor microenvironment to overcome immunosuppression in multiple myeloma

Joshua Rivera, Qi Yan, Saeed Daneshmandi, Romain Lannes et autres

ABSTRACT: Understanding the roles of myeloid cells in the tumor microenvironment (TME) has emerged as a promising strategy to identify novel targets to counteract the immunosuppressive barriers protecting multiple myeloma (MM). Neutrophils are a new cancer research focus due to their potential …

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Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export

Saeed Daneshmandi, Yan Qi, Jee Eun Choi, Eriko Katsuta et autres

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Exportin 1 (XPO1) blockade regulates immunosuppressive function of tumor myeloid derived suppressor cells

Saeed Daneshmandi, Yan Qi, Jee Eun Choi, Eriko Katsuta et autres

Abstract Myeloid-derived suppressor cells (MDSCs) are key regulators of immune responses in the tumor microenvironment (TME). Here we report the pivotal role played by Exportin 1 (XPO1) in shaping the phenotype and suppressive function of tumor associated MDSCs, thereby influencing tumor progression. …

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Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Saeed Daneshmandi, Jee Eun Choi, Yan Qi, Cameron R. MacDonald et autres

Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy in a preclinical lymphoma model. Mechanistically, we show that triggering …

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Abstract 105: Understanding the role of β2-adrenergic receptor signaling on type II innate lymphoid cells in cancer

Jee Eun Choi, Cameron R. MacDonald, Saeed Daneshmandi, Jianmin Wang et autres

Abstract Increased norepinephrine (NE) due to chronic stress can activate adrenergic receptors, specifically β2-adrenergic receptors (β2AR), to produce an immunosuppressive tumor microenvironment (TME). Previous work by our lab demonstrated that tumor burden can be reduced by blocking β2AR signaling. Immune cells express …

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Consideration of the importance of measuring thermal discomfort in biomedical research

Cameron R. MacDonald, Jee Eun Choi, Chi‐Chen Hong, Elizabeth A. Repasky

Core temperature stability is the result of a dynamically regulated balance of heat loss and gain, which is not reflected by a simple thermometer reading. One way in which these changes manifest is in perceived thermal comfort, 'feeling too cold' or 'feeling …

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The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

Ophélie Alyssa Martin, Morgane Thomas, Marie Marquet, Charlotte Bruzeau et autres

Intoduction Two scaffold/matrix attachment regions (5’- and 3’-MARsEµ) flank the intronic core enhancer (cEµ) within the immunoglobulin heavy chain locus (IgH). Besides their conservation in mice and humans, the physiological role of MARsEµ is still unclear and their involvement in somatic hypermutation …

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WT vs Galectin-3 Knockout CD8 T Cell Gene Expression Analysis in GvHD

Hemn Mohammadpour, Takemasa Tsuji, Cameron R. MacDonald, Joseph L. Sarow et autres

At D7 post-bone marrow transplant (BMT), splenocytes from 5-6 BMT recipient Balb/c mice were pooled and the CD8+ donor T cells from C57BL/6 mice were isolated. These donor CD8+ T cells were analyzed using the Nanostring nCounter® Immunology Panel mRNA microarray.

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WT vs Galectin-3 Knockout CD4 T Cell Gene Expression Analysis in GvHD

Hemn Mohammadpour, Takemasa Tsuji, Cameron R. MacDonald, Joseph L. Sarow et autres

At D7 post-bone marrow transplant (BMT), splenocytes from 5-6 BMT recipient Balb/c mice were pooled and the CD4+ donor T cells from C57BL/6 mice were isolated. These donor CD4+ T cells were analyzed using the Nanostring nCounter® Immunology Panel mRNA microarray.

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