Joanne Chan

Polyclonal origins of human premalignant colorectal lesions

Debra Van Egeren, Ryan O. Schenck, Aziz Khan, Aaron M. Horning et autres

ABSTRACT Cancer is generally thought to be caused by expansion of a single mutant cell 1 . However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations 2,3 . Detecting polyclonal tumor initiation …

us, ae, cn (code pays fourni par la source)

Multi-omic Analysis of Familial Adenomatous Polyposis Reveals Molecular Pathways and Polyclonal Spreading Associated with Early Tumorigenesis

M Snyder, Aaron M. Horning, Edward D. Esplin, Si Wu et autres

Abstract Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected patients, leading to colorectal cancer (CRC), and is an ideal model to study early transition to CRC. We performed deep multi-omic profiling of 135 normal mucosal, …

us, cn (code pays fourni par la source)

A genome-wide atlas of co-essential modules assigns function to uncharacterized genes

Michael Wainberg, Roarke A. Kamber, Akshay Balsubramani, Robin M. Meyers et autres

us (code pays fourni par la source)

RobNorm: model-based robust normalization method for labeled quantitative mass spectrometry proteomics data

Meng Wang, Lihua Jiang, Ruiqi Jian, Joanne Chan et autres

MOTIVATION: Data normalization is an important step in processing proteomics data generated in mass spectrometry experiments, which aims to reduce sample-level variation and facilitate comparisons of samples. Previously published methods for normalization primarily depend on the assumption that the distribution of protein …

us (code pays fourni par la source)

A Quantitative Proteome Map of the Human Body

Lihua Jiang, Meng Wang, Shin Lin, Ruiqi Jian et autres

us, se (code pays fourni par la source)

A genome-wide almanac of co-essential modules assigns function to uncharacterized genes

Michael Wainberg, Roarke A. Kamber, Akshay Balsubramani, Robin M. Meyers et autres

SUMMARY A central remaining question in the post-genomic era is how genes interact to form biological pathways. Measurements of gene dependency across hundreds of cell lines have been used to cluster genes into ‘co-essential’ pathways, but this approach has been limited by …

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A Quantitative Proteome Map of the Human Body

Lihua Jiang, Meng Wang, Shin Lin, Ruiqi Jian et autres

Abstract Determining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from 12,627 genes across 32 …

us (code pays fourni par la source)

RobNorm: Model-Based Robust Normalization Method for Labeled Quantitative Mass Spectrometry Proteomics Data

Meng Wang, Lihua Jiang, Ruiqi Jian, Joanne Chan et autres

Abstract Motivation Data normalization is an important step in processing proteomics data generated in mass spectrometry (MS) experiments, which aims to reduce sample-level variation and facilitate comparisons of samples. Previously published methods for normalization primarily depend on the assumption that the distribution …

us (code pays fourni par la source)

Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen

Edwin E. Jeng, Varun Bhadkamkar, Nnejiuwa U. Ibe, Haley Gause et autres

us (code pays fourni par la source)

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

Michael S. Haney, Christopher J. Bohlen, David W. Morgens, James Ousey et autres

us, fr, ca (code pays fourni par la source)

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Alvaro Barbeira, Scott Dickinson, Rodrigo Bonazzola, Jiamao Zheng et autres

Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference …

us, il, es, ch, pt, nl, kr, gb, ca, br (code pays fourni par la source)

Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family

Yonghong Li, Petra Nowotny, Peter Holmans, Scott Smemo et autres

Although several genes have been implicated in the development of the early-onset autosomal dominant form of Alzheimer's disease (AD), the genetics of late-onset AD (LOAD) is complex. Loci on several chromosomes have been linked to the disease, but so far only the …

gb (code pays fourni par la source)