Aziz Khan

JASPAR 2026: expansion of transcription factor binding profiles and integration of deep learning models

Damla Ovek, Ieva Rauluševičiūtė, Dina Ruud Aronsen, Romain Blanc‐Mathieu et autres

JASPAR (https://jaspar.elixir.no/) is an open-access database that has provided high-quality, manually curated, and non-redundant DNA binding profiles for transcription factors (TFs) as position frequency matrices (PFMs) for over 20 years. We expanded the CORE (306 new profiles, 12% increase) and UNVALIDATED (433, …

no, fr, be, us, ca, gb, hr, ae, fi, dk (code pays fourni par la source)

High-confidence structural predictions of extrachromosomal DNA with ecDNAInspector

Sophia Pribus, Yanding Zhao, Zhicheng Ma, Clemens L. Weiß et autres

Extrachromosomal DNA (ecDNA) are circularized genomic elements that reside outside canonical chromosomes. ecDNA amplify oncogene copy number, enhance chromatin accessibility, and act as mobile enhancers through cis- and trans-regulatory interactions, collectively boosting oncogene expression. ecDNA has been implicated in tumor progression, intratumoral …

us, ae, ca (code pays fourni par la source)

Polyclonal origins of human premalignant colorectal lesions

Debra Van Egeren, Ryan O. Schenck, Aziz Khan, Aaron M. Horning et autres

Cancer is generally thought to be caused by expansion of a single mutant cell 1 . However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations 2,3 . Detecting polyclonal tumor initiation is …

us, ae, cn (code pays fourni par la source)

Antimicrobial resistance patterns and high prevalence of the mcr-1 gene in pathogenic Escherichia coli from diseased poultry

Aziz Khan, Awais Ihsan, Farhat Ullah, Obaid Ullah et autres

This study assessed the prevalence of the mcr-1 gene, which provides resistance to colistin (polymyxin E), in Escherichia coli strains isolated from sick poultry in the Peshawar, Mardan, and Charsadda regions of Pakistan. Samples were collected from 246 poultry birds showing symptoms …

pk, cn, sa (code pays fourni par la source)

Polyclonal origins of human premalignant colorectal lesions

Debra Van Egeren, Ryan O. Schenck, Aziz Khan, Aaron M. Horning et autres

ABSTRACT Cancer is generally thought to be caused by expansion of a single mutant cell 1 . However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations 2,3 . Detecting polyclonal tumor initiation …

us, ae, cn (code pays fourni par la source)

Abstract 6355: Mapping the genetic, epigenetic, and microenvironmental evolution of HER2-positive breast cancer during neoadjuvant therapy

Seongyeol Park, Eran Kotler, Zhicheng Ma, Kathleen E. Houlahan et autres

Abstract Breast cancer, characterized by considerable heterogeneity, showcases genetic and epigenetic variability among individual tumors and their constituent cells. Notably, this intratumoral heterogeneity (ITH) can drive clonal evolution and therapy resistance, particularly in Human Epidermal Growth Factor Receptor 2 (HER2)-positive cancers. Despite …

us (code pays fourni par la source)

Pure Hydrocarbon Hosts Enabling Efficient Multi‐Resonance TADF Blue‐Emitting Organic Light‐Emitting Diodes

Yue‐Jian Yang, Denis Ari, Zhe-Hong Yu, Kelvine Lettelier et autres

Abstract Pure hydrocarbon (PHC) materials are a class of highly efficient and stable host materials for organic light‐emitting diodes (OLEDs), composed solely of carbon and hydrogen atoms. Despite recent great advancements in PHC research, their applications are still mainly limited to phosphorescent …

tw, cn, fr (code pays fourni par la source)

Pure Hydrocarbon Hosts Enabling Efficient Multi‐Resonance TADF Blue‐Emitting Organic Light‐Emitting Diodes

Yue‐Jian Yang, Denis Ari, Zhe-Hong Yu, Kelvine Lettelier et autres

Abstract Pure hydrocarbon (PHC) materials are a class of highly efficient and stable host materials for organic light‐emitting diodes (OLEDs), composed solely of carbon and hydrogen atoms. Despite recent great advancements in PHC research, their applications are still mainly limited to phosphorescent …

tw, cn, fr (code pays fourni par la source)

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition

Noah F. Greenwald, Iris Nederlof, C. H. Sowers, Daisy Yi Ding et autres

Immune checkpoint inhibition (ICI) has fundamentally changed cancer treatment. However, only a minority of patients with metastatic triple negative breast cancer (TNBC) benefit from ICI, and the determinants of response remain largely unknown. To better understand the factors influencing patient outcome, we …

us, nl, de (code pays fourni par la source)

Green TADF emitters based on adamantane-substituted acridine donor/diphenyl ketone acceptor in D-A and D-A-D systems

Aziz Khan, Yu‐Yang Ma, Sarvendra Kumar, Shijie Ge et autres

cn, kr (code pays fourni par la source)

Complex rearrangements fuel ER+ and HER2+ breast tumours

Kathleen E. Houlahan, Lise Mangiante, Cristina Sotomayor-Vivas, Alvina Adimoelja et autres

Breast cancer is a highly heterogeneous disease whose prognosis and treatment as defined by the expression of three receptors—oestrogen receptor (ER), progesterone receptor and human epidermal growth factor receptor 2 (HER2; encoded by ERBB2)—is insufficient to capture the full spectrum of clinical …

us (code pays fourni par la source)

Thermally activated delayed fluorescence emitters with oxygen-bridged triarylborane acceptors for pure blue organic light emitting diodes

Haixiao Jiang, Yue-Jian Yang, Shi-Jie Ge, Jian-Rong Wu et autres

cn (code pays fourni par la source)