Philippe Lière

Multiple sclerosis lesions exhibit sex-specific steroid changes

Sabina Luchetti, Matthew R. J. Mason, Philippe Lière, Antoine Pianos et autres

Sex differences in disease susceptibility and progression in multiple sclerosis (MS) indicate hormonal influences. We previously found sex differences in steroidogenic enzyme expression in mixed active/inactive (mixed) and inactive lesions, suggesting increased synthesis and signalling of progesterone in females and of estradiol …

nl, fr (code pays fourni par la source)

Mild TBI Changes Brain and Plasma Neurosteroid Levels in Mice

Kosisochukwu Emmanuel Umeasalugo, Igor Khalin, Burcu Seker, Philippe Lière et autres

Mild traumatic brain injury (mTBI) accounts for 80% of all TBI, may be associated with chronic impairments, and is difficult to diagnose due to a lack of objective markers. In this study, we investigated whether neurosteroids can serve as blood biomarkers for …

de, fr, us (code pays fourni par la source)

The translocator protein 18 kDa (TSPO) ligand etifoxine in an animal model of anxiety: Line- and sex-dependent effects on emotionality, stress reactivity, spine density, oxytocin receptors, steroids, and microbiome composition

L.J. Fischer, Bjarne Paschke, Michaël Schumacher, Philippe Lière et autres

The treatment of stress-related disorders such as anxiety and depression is still challenging. One potential therapeutical option are neurosteroids. Their synthesis is promoted by ligands of the mitochondrial translocator protein 18 kDa (TSPO). We tested the TSPO ligand etifoxine (ETX) in a …

de, fr (code pays fourni par la source)

The walnut tree as a source of progesterone for reproductive control in goats

Philippe Chemineau, Anna‐Liisa Laine, Dominique Gennetay, Chantal Porte et autres

Intravaginal sponges impregnated with the progesterone (P4) analogue fluorogestone acetate (FGA) induce synchronous oestrous behaviour and normal ovulatory cycle in goats. To explore alternatives using natural P4 from plants, we developed a method of ethanolic extraction and a specific enzyme immunoassay (EIA) …

fr, mx (code pays fourni par la source)

92. Chasteberry fruits and walnut leaves contain phytoprogestins and could be considered as an alternative to synthetic progestogens for synchronising the oestrus of gilts

Ghylène Goudet, Philippe Chemineau, Philippe Lière, Anna‐Liisa Laine et autres

fr, Maroc (code pays fourni par la source)

Neurosteroids and translocator protein 18 kDa (TSPO) ligands as novel treatment options in depression

Marco Riebel, Lisa-Marie Brunner, Caroline Nothdurfter, Simon Wein et autres

Abstract Recently, the gamma-aminobutyric acid (GABA) system has come into focus for the treatment of anxiety, postpartum depression, and major depressive disorder. Endogenous 3α-reduced steroids such as allopregnanolone are potent positive allosteric modulators of GABAA receptors and have been known for decades. …

de, fr (code pays fourni par la source)

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease

Arpit Kumar Pradhan, Tatjana Neumüller, Claudia Klug, Severin Fuchs et autres

Abstract Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). It affects cognition and leads to memory impairment. The mitochondrial translocator protein (TSPO) plays an essential role in maintaining mitochondrial homeostasis and has been implicated in several neuronal disorders …

de, fr (code pays fourni par la source)

Chasteberry (Vitex agnus castus) as an alternative to synthetic progestogens? Composition of the fruits and effects on male and female pigs

Ghylène Goudet, Philippe Lière, Antoine Pianos, Anne-Lyse Lainé et autres

International audience

fr (code pays fourni par la source)

Saliva steroidome and metabolome in mare during anestrus, estrus cycle and gestation

Stéphane A. Beauclercq, Cécile Douet, Antoine Pianos, L. Haddad et autres

International audience

fr (code pays fourni par la source)

Disease stage-dependent changes in brain levels and neuroprotective effects of neuroactive steroids in Parkinson's disease

Sabina Luchetti, Philippe Lière, Antoine Pianos, Ronald W. H. Verwer et autres

Neuroactive steroids are known neuroprotective agents and neurotransmitter regulators. We previously found that expression of the enzymes synthesizing 5α-dihydroprogesterone (5α-DHP), allopregnanolone (ALLO), and dehydroepiandrosterone sulfate (DHEAS) were reduced in the substantia nigra (SN) of Parkinson's Disease (PD) brain. Here, concentrations of a …

nl, fr (code pays fourni par la source)

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease

Arpit Kumar Pradhan, Tatjana Neumüller, Claudia Klug, Severin Fuchs et autres

ABSTRACT Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). There is increasing evidence that depression may precede AD and may be an early manifestation of dementia, suggesting common mechanisms underlying both diseases. Ligands targeting the mitochondrial translocator protein …

de, fr (code pays fourni par la source)

The different natural estrogens promote endothelial healing through distinct cell targets

Morgane Davezac, Rana Zahreddine, Mélissa Buscato, Natalia F. Smirnova et autres

The main estrogen, 17β-estradiol (E2), exerts several beneficial vascular actions through estrogen receptor α (ERα) in endothelial cells. However, the impact of other natural estrogens such as estriol (E3) and estetrol (E4) on arteries remains poorly described. In the present study, we …

fr, be (code pays fourni par la source)