Ronald W. H. Verwer

Progesterone receptor distribution in the human hypothalamus and its association with suicide

Lin Zhang, Ronald W. H. Verwer, Joop van Heerikhuize, Paul John Lucassen et autres

Abstract The human hypothalamus modulates mental health by balancing interactions between hormonal fluctuations and stress responses. Stress-induced progesterone release activates progesterone receptors (PR) in the human brain and triggers alterations in neuropeptides/neurotransmitters. As recent epidemiological studies have associated peripheral progesterone levels with …

nl, us, gb (code pays fourni par la source)

Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide

Zala Slabe, Rawien A. Balesar, Ronald W. H. Verwer, Gorazd Drevenšek et autres

Introduction: Pituitary adenylate cyclase-activating peptide (PACAP) is a stress-related neuropeptide that is produced in several brain areas. It acts by 3 receptors: PACAP type-1 (PAC1), vasoactive intestinal peptide (VIP) -1 and -2 (VPAC1 and 2). Data on polymorphisms in PACAP and PAC1 …

nl, si (code pays fourni par la source)

Disease stage-dependent changes in brain levels and neuroprotective effects of neuroactive steroids in Parkinson's disease

Sabina Luchetti, Philippe Lière, Antoine Pianos, Ronald W. H. Verwer et autres

Neuroactive steroids are known neuroprotective agents and neurotransmitter regulators. We previously found that expression of the enzymes synthesizing 5α-dihydroprogesterone (5α-DHP), allopregnanolone (ALLO), and dehydroepiandrosterone sulfate (DHEAS) were reduced in the substantia nigra (SN) of Parkinson's Disease (PD) brain. Here, concentrations of a …

nl, fr (code pays fourni par la source)

Alterations in pituitary adenylate cyclase-activating polypeptide in major depressive disorder, bipolar disorder, and comorbid depression in Alzheimer's disease in the human hypothalamus and prefrontal cortex

Zala Slabe, Rawien A. Balesar, Ronald W. H. Verwer, Joop J. van Heerikhuize et autres

BACKGROUND: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is involved in the stress response and may play a key role in mood disorders, but no information is available on PACAP for the human brain in relation to mood disorders. METHODS: PACAP-peptide levels were determined …

nl, si (code pays fourni par la source)

Stress-associated purinergic receptors code for fatal suicidality in the hippocampal-hypothalamic-prefrontal circuit

Lin Zhang, Ronald W. H. Verwer, Joop van Heerikhuize, Rawien A. Balesar et autres

Abstract Imbalanced purine metabolism is a key neurological basis for suicide and mood disorders (MD), wherein purinergic receptors in stress-sensitive cerebral regions are thought to be differentially activated. A hippocampal network that links the hypothalamus and prefrontal cortex implements an affective sensation …

nl, us, si, cz (code pays fourni par la source)

Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features

Lin Zhang, Ronald W. H. Verwer, Juan Zhao, Inge Huitinga et autres

BACKGROUND: To establish whether major depressive disorder (MDD), suicidal behaviors and psychotic features contribute to glial alterations in the human prefrontal cortex. MATERIALS AND METHODS: We compared mRNA expression using real-time qPCR of 17 glia related genes in the dorsolateral prefrontal cortex …

nl (code pays fourni par la source)

Sex differences in the neuropathological hallmarks of Alzheimer’s disease: focus on cognitively intact elderly individuals

Yuting Hu, Jackson Tyler Boonstra, Hugo McGurran, Jochem Stormmesand et autres

AIMS: Women are more vulnerable to Alzheimer's disease (AD) than men. We investigated (i) whether and at what age the AD hallmarks, that is, β-amyloid (Aβ) and hyperphosphorylated Tau (p-Tau) show sex differences; and (ii) whether such sex differences may occur in …

cn, nl (code pays fourni par la source)

Author response for "Sex differences in the neuropathological hallmarks of Alzheimer's disease: focus on cognitively intact elderly individuals"

Yuting Hu, Jackson Tyler Boonstra, Hugo McGurran, Jochem Stormmesand et autres

Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder: Relation to psychotic features

Lin Zhang, Ronald W. H. Verwer, Paul John Lucassen, Inge Huitinga et autres

nl (code pays fourni par la source)

Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide

Lin Zhang, Ronald W. H. Verwer, Paul John Lucassen, Inge Huitinga et autres

nl (code pays fourni par la source)

Human Brain Slice Culture: A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds

Xin‐Rui Qi, Ronald W. H. Verwer, Ai‐Min Bao, Rawien A. Balesar et autres

cn, nl (code pays fourni par la source)

Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide

J. Zhao, Ronald W. H. Verwer, Shangfeng Gao, Xin‐Rui Qi et autres

nl (code pays fourni par la source)