Irene Portilla

Elevated Plasma GDF-15 Levels are Associated with the Immune Non-Responder Phenotype in People with HIV

Aida López López, Jacobo Alonso Domínguez, Inés Martínez Barros, Alexandre Pérez‐González et autres

INTRODUCTION: Most people with HIV (PWH) achieve immune recovery with antiretroviral therapy (ART); however, a clinically relevant subset, known as immune non-responders (INRs), fails to restore CD4+ T-cell counts despite sustained virological suppression and shows persistent immune dysfunction. Growth differentiation factor 15 …

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HIV-1 APOBEC-context Mutations Detected by Next-Generation Sequencing in Plasma: Implications for Drug Resistance Interpretation

Marta Illescas-López, Paloma Muñoz, Adolfo de Salazar, Rafael Delgado et autres

BACKGROUND & AIMS: APOBEC3-mediated cytidine deamination produces characteristic G→A substitutions in HIV genomes, classically described in proviral DNA but also detectable in plasma HIV-1 RNA using next-generation sequencing (NGS). APOBEC-signature mutations reflect enrichment of G→A substitutions in APOBEC target motifs, whereas APOBEC-context …

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Beyond Surveillance Mutations: Long-Term Trends and Clinical Relevance of Transmitted HIV Drug Resistance in Spain (2007–2023)

Paloma Muñoz Báez, Marta Illescas López, Adolfo de Salazar, Iker Falces Romero et autres

Background: While surveillance drug resistance mutations (SDRMs) remain essential for monitoring transmitted drug resistance (TDR), the clinical impact of transmitted resistance for current first-line regimens has become increasingly important. We aimed to update estimates of TDR in Spain and assess its clinical …

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Persistence of late HIV diagnosis and poorer response to antiretrovirals: a comparison between migrants and native-born people with HIV in Spain

José A. Pérez‐Molina, Jose A. Perez-Molina, Miguel Suárez-Robles, María Belén Sánchez-López et autres

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Towards tuberculosis elimination in people with HIV on antiretroviral therapy: evidence from a two-decade nationwide cohort in Spain

Roser Navarro-Soler, Alfonso Muriel, Chiara Fanciulli, José I. Bernardino et autres

BACKGROUND: Tuberculosis (TB) incidence among people with HIV (PWH) has fallen in many high-income settings, yet residual risk persists, and tools to identify those still vulnerable are limited. This study aimed to evaluate TB incidence trends, identify risk factors, and develop a …

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Changes in Body Mass Index in Children and Adolescents Living With Human Immunodeficiency Virus in Europe and Thailand Starting Dolutegravir

Elizabeth Chappell, Siobhan Crichton, Intira Jeannie Collins, G Valle et autres

Abstract Background Excess weight gain has been reported in some adults on dolutegravir (DTG), but data in children/adolescents living with human immunodeficiency virus (CALHIV) are limited. Methods CALHIV aged 2–17 years at DTG start from 15 observational cohorts across Europe and Thailand …

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The moderation effect of chemsex on the association between sexual sensation seeking and self-esteem in men with HIV who have sex with men

Cristian Alcocer‐Bruno, Nicolás Ruiz‐Robledillo, Rosario Ferrer‐Cascales, Irene Portilla

Although evidence suggests an association between sexual sensation seeking (SSS) and self-esteem (SE), the moderating effect of chemsex on this relationship has not been extensively examined, particularly in men who have sex with men (MSM) with HIV. The main aim of the …

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Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size

Erick De La Torre Tarazona, Elisa Moraga, Raúl Vaquer, Sonsoles Sánchez-Palomino et autres

The elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation could improve the effectiveness of strategies aimed at …

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Long-Term Health-Related Quality of Life in People Living with HIV Who Present to Care with AIDS or Severe Immunodeficiency: The CoRIS AIDS Survivors Study

Julia Portilla-Tamarit, María José Fuster‐RuizdeApodaca, Irene Portilla, Sergio Reus et autres

Our aim was to evaluate long-term health-related quality of life (HRQoL) in 253 people living with HIV (PLH) from the CoRIS cohort presenting to care with advanced HIV disease (AIDS or CD4 ≤ 100 cells/µL) and who had survived ≥ 5 years. …

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Viral Suppression, Viral Failure, and Safety Outcomes in Children and Adolescents With HIV on Dolutegravir in Europe and Thailand

Karen Scott, John O’Rourke, Charlotte Jackson, Luminita Ene et autres

BACKGROUND: Dolutegravir (DTG) is a preferred anchor antiretroviral therapy (ART) for children and adolescents with HIV (CAWH). METHODS: We assessed the effectiveness and safety of DTG in CAWH aged 0-18 years at DTG start in routine care in Europe and Thailand, evaluating …

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Long-term effectiveness and tolerability of dolutegravir/lamivudine in treatment-naive people with HIV: an analysis of a multicentre cohort at 96 weeks

Inés Suárez‐García, Belén Alejos, Cristina Moreno, Juan Martín Torres et autres

OBJECTIVES: To evaluate the long-term effectiveness, persistence and tolerability of dolutegravir (DTG)/lamivudine (3TC), compared with the most frequently prescribed first-line treatment regimens, among antiretroviral-naive people with HIV from CoRIS, a multicentre cohort in Spain, in 2018-23. METHODS: We used multivariable regression models …

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Impact of mental disorders on low adherence to antiretroviral therapy in people living with HIV in Spain

Irene Portilla, María Rubio‐Aparicio, Nicolás Ruiz‐Robledillo, Rosario Ferrer‐Cascales et autres

The relationship between mental disorders other than depression or anxiety, and low adherence to both antiretroviral treatment (ART) and linkage to HIV care are unclear. The aim of our study was to compare the prevalence of mental disorders in people living with …

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