Julia Portilla-Tamarit

HIV-1 APOBEC-context Mutations Detected by Next-Generation Sequencing in Plasma: Implications for Drug Resistance Interpretation

Marta Illescas-López, Paloma Muñoz, Adolfo de Salazar, Rafael Delgado et autres

BACKGROUND & AIMS: APOBEC3-mediated cytidine deamination produces characteristic G→A substitutions in HIV genomes, classically described in proviral DNA but also detectable in plasma HIV-1 RNA using next-generation sequencing (NGS). APOBEC-signature mutations reflect enrichment of G→A substitutions in APOBEC target motifs, whereas APOBEC-context …

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Long-Term Health-Related Quality of Life in People Living with HIV Who Present to Care with AIDS or Severe Immunodeficiency: The CoRIS AIDS Survivors Study

Julia Portilla-Tamarit, María José Fuster‐RuizdeApodaca, Irene Portilla, Sergio Reus et autres

Our aim was to evaluate long-term health-related quality of life (HRQoL) in 253 people living with HIV (PLH) from the CoRIS cohort presenting to care with advanced HIV disease (AIDS or CD4 ≤ 100 cells/µL) and who had survived ≥ 5 years. …

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Health-Related Quality of Life in People with Advanced HIV Disease, from 1996 to 2021: Systematic Review and Meta-analysis

Irene Portilla, María Rubio‐Aparicio, María José Fuster‐RuizdeApodaca, Julia Portilla-Tamarit et autres

The purpose of the study was to assess the effects of advanced HIV disease (AHD) on health-related quality of life (HRQoL) in PLHIV, the changes in HRQoL outcomes over the last 25 years, and the differences between countries according to level of …

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Pathological Findings Associated With SARS-CoV-2 on Postmortem Core Biopsies: Correlation With Clinical Presentation and Disease Course

José Manuel Ramos, Cristian Herrera-García, Sandra Silva‐Ortega, Julia Portilla-Tamarit et autres

Background Autopsies can shed light on the pathogenesis of new and emerging diseases. Aim To describe needle core necropsy findings of the lung, heart, and liver in decedents with COVID-19. Material Cross-sectional study of needle core necropsies in patients who died with …

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Non-immune haemolytic anaemia in a patient with acute hepatitis B

Antonio Amo-Lozano, Julia Portilla-Tamarit, Joaquín Portilla

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Impact of Advanced HIV Disease on Quality of Life and Mortality in the Era of Combined Antiretroviral Treatment

Julia Portilla-Tamarit, Sergio Reus, Irene Portilla, María José Fuster Ruiz-de-Apodaca et autres

Currently, AIDS or severe immunodeficiency remains as a challenge for people with HIV (PWHIV) and healthcare providers. Our purpose was to analyze the impact of advanced HIV disease (AHD) on mortality, life expectancy and health-related quality of life (HRQoL). We reviewed cohort …

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Anemia hemolítica no inmune en un paciente con hepatitis B aguda

Antonio Amo-Lozano, Julia Portilla-Tamarit, Joaquín Portilla

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