Shokei Kim‐Mitsuyama

Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage

Hiroki Uchikawa, Koki Kameno, Keitaro Kai, Sosho Kajiwara et autres

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Loss of body weight in old 5xFAD mice and the alteration of gut microbiota composition

Koki Kameno, Yu Hasegawa, Kenyu Hayashi, Yushin Takemoto et autres

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Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation

Yuichi Kimura, Yasuhiro Izumiya, Satoshi Araki, Satoru Yamamura et autres

Background: Sirt7 is a recently identified sirtuin and has important roles in various pathological conditions, including cancer progression and metabolic disorders. It has previously been reported that Sirt7 is a key molecule in acute myocardial wound healing and pressure overload-induced cardiac hypertrophy. …

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Salt-Sensitive Hypertension of the Renal Tubular Cell–Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice

Akiko Hiramatsu, Yuichiro Izumi, Koji Eguchi, Naomi Matsuo et autres

The kidney plays a crucial role in blood pressure (BP) regulation by controlling sodium reabsorption along the nephron. NFAT5 (nuclear factor of activated T-cells 5) is a transcription factor that is expressed in various tissues including the kidney and is activated at …

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Corrigendum to: LCZ696, Angiotensin II Receptor-Neprilysin Inhibitor, Ameliorates High-Salt-Induced Hypertension and Cardiovascular Injury More Than Valsartan Alone

Hiroaki Kusaka, Daisuke Sueta, Nobutaka Koibuchi, Yu Hasegawa et autres

Corrigendum to “LCZ696, Angiotensin II Receptor-Neprilysin Inhibitor, Ameliorates High-Salt-Induced Hypertension and Cardiovascular Injury More Than Valsartan Alone” by Kusaka et al. Am J Hypertens (2015) 28 (12): 1409–1417. doi:10.1093/ajh/hpv015 The legends in Figure 4 (A) were incorrect. The labels “Val” and “LCZ” …

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The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats

Yu Hasegawa, Yushin Takemoto, Kenyu Hayashi, Koki Kameno et autres

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Tissue Inhibitor of Metalloproteinase-3 Knockout Mice Exhibit Enhanced Energy Expenditure through Thermogenesis

Nobuyo Maeda, Yuichi Oike, Eiichiro Yamamoto, Mitsuru Ohishi et autres

Tissue inhibitors of metalloproteinases (TIMPs) regulate matrix metalloproteinase activity and maintain extracellular matrix homeostasis. Although TIMP-3 has multiple functions (e.g., apoptosis, inhibition of VEGF binding to VEGF receptor, and inhibition of TNFα converting enzyme), its roles in thermogenesis and metabolism, which influence …

Reduction in hsCRP levels is associated with decreased incidence of cardiovascular events in Japanese hypertensive women but not in men

Shokei Kim‐Mitsuyama, Hirofumi Soejima, Osamu Yasuda, Koichi Node et autres

To test our hypothesis that the magnitude of reduction in hsCRP achieved by antihypertensive medications may predict the benefit for cardiovascular outcomes in hypertensive individuals, we performed subanalysis of the ATTEMPT-CVD study. The hypertensive participants enrolled in the ATTMEPT-CVD study were categorized …

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Anti-apoptotic effects of BDNF-TrkB signaling in the treatment of hemorrhagic stroke

Yu Hasegawa, Kenyu Hayashi, Yushin Takemoto, Shokei Kim‐Mitsuyama

Stroke is a primary cause of death and a leading cause of disability throughout the world. Although researchers have long studied ways for improving mortality and morbidity, few effective treatments are available for patients with stroke. Effective treatments for hemorrhagic stroke (HS) …

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The Stabilization of Central Sympathetic Nerve Activation by Renal Denervation Prevents Cerebral Vasospasm after Subarachnoid Hemorrhage in Rats

Yushin Takemoto, Yu Hasegawa, Kenyu Hayashi, Tadashi Hamasaki et autres

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Total adiponectin is associated with incident cardiovascular and renal events in treated hypertensive patients: subanalysis of the ATTEMPT-CVD randomized trial

Shokei Kim‐Mitsuyama, Hirofumi Soejima, Osamu Yasuda, Koichi Node et autres

The predictive value of serum adiponectin for hypertensive cardiovascular outcomes is unknown. This study was performed to investigate the association of adiponectin with incident cardiovascular and renal events (CV events) in hypertensive patients. We performed post-hoc analysis on 1,228 hypertensive patients enrolled …

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Enhanced oxidative stress contributes to worse prognosis and delayed neurofunctional recovery after striatal intracerebral hemorrhage in 5XFAD mice

Kenyu Hayashi, Yu Hasegawa, Yushin Takemoto, Cheng Cao et autres

Abstract Although Alzheimer's disease (AD) is associated with an increased risk of intracerebral hemorrhage (ICH) caused by hypertension and cerebral amyloid angiopathy, the precise clinical course after hypertensive ICH in AD patients is still unknown. In this study, we investigated how striatal …

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