Koki Kameno

Real-world clinical decision of andexanet alfa administration for intracranial hemorrhage during anticoagulant therapy using factor Xa inhibitor

Shigeo Yamashiro, Keisuke Harada, Shunsuke Izumi, Yusuke Morikawa et autres

Introduction: Andexanet alfa shows excellent hemostatic efficacy in treating intracranial hemorrhage (ICH) during Xa inhibitor therapy. However, its optimal use remains uncertain. Aim of the study: This study aims to evaluate our clinical experience in managing Xa inhibitor-related ICH to clarify its …

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Determination of a Personalized Surgical Trajectory Using Three-dimensional Image Analysis and Surgical Outcomes in Endoscopic Hematoma Evacuation for Putaminal Hemorrhage

Shigeo Yamashiro, Shunsuke Izumi, Keisuke Harada, Koki Kameno et autres

当院では脳内出血に対する内視鏡下血腫除去術の際，CTの3D画像解析から適切なアプローチ方向を症例ごとに設計している．この方法で行った症例の治療成績を検討した．2016年4月から2025年3月までに施行した61例の被殻出血を対象に，3D画像解析ソフトで作成した血腫と頭蓋骨のハイブリッド画像から，血腫の長軸方向を重視しつつ，皮質からの最短距離などの因子も加え最終的な穿頭部位と方向を決定した．設計どおりの正確な穿刺のため，画像から計測した穿頭部位と対側目標点に沿って，自作穿刺器具を用いて正確に穿刺する工夫を行った．血腫量の中央値は65.4ml，除去率78.4％であった．出血性有害事象を3.3％に認めた．アプローチ別に血腫長軸方向群と非長軸群に分け比較しても，血腫除去率や機能予後に有意差は認められず，臨床的に妥当なアプローチ選択がなされていると考えられた．3D画像解析は血腫形状の立体的把握を考慮した適切なアプローチの選定に有用と思われる．今後，さらなる症例の蓄積と検討が必要である．

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Artificial dural regeneration matrix as a substitute for autologous tissue in indirect bypass in Moyamoya disease: Investigation of a rat model of chronic cerebral hypoperfusion

Koki Kameno, Yasuyuki Kaku, Y Ohmori, Yushin Takemoto et autres

Indirect bypass using autologous tissue is effective in Moyamoya disease, especially among pediatric patients. This study aimed to evaluate the effectiveness of indirect bypass using DuraGen (absorbable artificial dura mater composed of collagen matrix), as a substitute for autologous tissue in a …

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Artificial dural regeneration matrix as a substitute for autologous tissue in indirect bypass in Moyamoya disease: Investigation of a rat model of chronic cerebral hypoperfusion

Koki Kameno, Yasuyuki Kaku, Y Ohmori, Yushin Takemoto et autres

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The Effects of Propofol Dosage on Postoperative Fluid Attenuated Inversion Recovery Imaging during Revascularization Surgery for Moyamoya Disease

Yasuyuki Kaku, Yushin Takemoto, Koki Kameno, Yuki Ohmori et autres

もやもや病に対する血行再建術において，麻酔法の違いが術後の神経症状の発現に及ぼす影響については議論の余地がある．近年，新たな麻酔薬の登場などにより，麻酔法も変化している．本研究では，もやもや病の血行再建術におけるプロポフォールの使用量が術後経過に及ぼす影響について検討した．

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Inhalational Anesthesia Reduced Transient Neurological Events After Revascularization Surgery for Moyamoya Disease

Yasuyuki Kaku, Y Ohmori, Koki Kameno, Hiroki Uchikawa et autres

BACKGROUND AND OBJECTIVES: The choice between inhalational and total intravenous anesthesia (TIVA) in revascularization surgery for Moyamoya disease (MMD) remains a topic of debate. Anesthesia methods have changed with the advent of new anesthetics. This study investigated whether modern anesthesia methods affected …

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Persistent brain exposure to high sodium induces stroke onset by upregulation of cerebral microbleeds and oxidative stress in hypertensive rats

Sosho Kajiwara, Yu Hasegawa, Kana Fujimori, Satoshi Tomiyasu et autres

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Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage

Hiroki Uchikawa, Koki Kameno, Keitaro Kai, Sosho Kajiwara et autres

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高齢5xFADマウスにおける体重減少と腸内細菌叢の変化

Koki Kameno

Loss of body weight in old 5xFAD mice and the alteration of gut microbiota composition

Koki Kameno, Yu Hasegawa, Kenyu Hayashi, Yushin Takemoto et autres

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The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats

Yu Hasegawa, Yushin Takemoto, Kenyu Hayashi, Koki Kameno et autres

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Spontaneous regression of nonfunctioning pituitary macroadenoma: A case report

Koki Kameno, Shigetoshi Yano, Naoki Shinojima, Jun‐ichi Kuratsu

A case involving a 13-year-old girl with nonfunctioning pituitary macroadenoma is discussed. The patient visited the hospital for checkup after experiencing a head injury secondary to syncope. A computed tomography (CT) scan revealed a pituitary mass with mildly higher density. Magnetic resonance …

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