Luc De Vries

What are Unveiling Factors Shaping the Outcome of Military Interventions in the Middle East? A Comparative Analysis of Syria, Libya, and Yemen

Luc De Vries

RGS12 and RGS14 GoLoco Motifs Are Gα i Interaction Sites with Guanine Nucleotide Dissociation Inhibitor Activity

Luc De Vries, David Peter Siderovski, Hélène Tronchère, Marilyn G. Farquhar et autres

The regulators of G-protein signaling (RGS) proteins accelerate the intrinsic guanosine triphosphatase activity of heterotrimeric G-protein alpha subunits and are thus recognized as key modulators of G-protein-coupled receptor signaling. RGS12 and RGS14 contain not only the hallmark RGS box responsible for GTPase-accelerating …

us (code pays fourni par la source)

Innovative Bioluminescence Resonance Energy Transfer Assay Reveals Differential Agonist-Induced D2 Receptor Intracellular Trafficking and Arrestin-3 Recruitment

Luc De Vries, Frédéric Finana, Claudie Cathala, Brice Ronsin et autres

fr (code pays fourni par la source)

Groene ICT verstevigt basis

Anda Counotte, Frank Hartkamp, Luc De Vries, Denny van der Vlist et autres

Groene ICT, een programma dat in 2008 startte om de negatieve milieueffecten van ict te minimaliseren, slaat de vleugels uit en richt zich nu ook op duurzaamheid en circulaire economie. Steeds meer onderwijsinstellingen sluiten zich aan, waardoor het programma een basis krijgt …

nl (code pays fourni par la source)

An internalization assay for Dopamine D2(short) Receptors using Bioluminescence Resonance Energy Transfer (BRET) technology

Luc De Vries, Frédéric Finana, Claudie Cathala, Brice Ronsin et autres

Internalization and subsequent degradation of GPCRs located at the plasmamembrane represent a desired therapeutic approach to eliminate those receptors whose activation leads to unwanted cellular behaviour. In order to follow the trafficking of endocytosed receptors and thus the efficacy of agents directing …

fr (code pays fourni par la source)

Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model

Emilie Lauressergues, Peter Heusler, Fabrice Lestienne, David Troulier et autres

The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The recently approved orally active drugs vismodegib (GDC-0449) and sonidegib (LDE-225) were not only efficacious for the treatment of advanced or metastatic BCC …

de, fr (code pays fourni par la source)

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2′-deoxycytidine in human leukemic KG1 cells

Stéphane Vispé, Arthur Deroide, Emeline Davoine, Cécile Desjobert et autres

// Stéphane Vispé 1 , Arthur Deroide 1 , Emeline Davoine 1 , Cécile Desjobert 1 , Fabrice Lestienne 2 , Lucie Fournier 1 , Natacha Novosad 1 , Sophie Bréand 3 , Jérôme Besse 3 , Florence Busato 4 , Jörg …

fr (code pays fourni par la source)

Establishment of Novel Preclinical Melanoma Models Resistant to Vemurafenib

Céline Robichon, Jean Philippe Annereau, Bruno Mattiello Gomes, Arnaud Pillon et autres

fr (code pays fourni par la source)

μ-opioid and 5-HT1A receptors heterodimerize and show signalling crosstalk via G protein and MAP-kinase pathways

Didier Cussac, Isabelle Rauly‐Lestienne, Peter Heusler, Frédéric Finana et autres

fr (code pays fourni par la source)

Inhibition of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) secretion by prodomain overexpression or pefabloc treatment as measured by a luciferase assay

Luc De Vries, Céline Robichon, Claudie Cathala, Michel Perez et autres

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protease that acts as a regulator of circulating plasma cholesterol levels by enhancing the endocytosis of the low density lipoprotein receptor (LDL‐R) at the cell surface of hepatocytes. In this study, we show …

fr (code pays fourni par la source)

Cellular BRET assay suggests a conformational rearrangement of preformed TrkB/Shc complexes following BDNF-dependent activation

Luc De Vries, Frédéric Finana, Frédéric Cachoux, Bernard Vacher et autres

fr (code pays fourni par la source)

Discovery of Novel Protease Activated Receptors 1 Antagonists with Potent Antithrombotic Activity in Vivo

Michel Perez, Marie Lamothe, Catherine Maraval, Etienne Mirabel et autres

Protease activated receptors (PARs) or thrombin receptors constitute a class of G-protein-coupled receptors (GPCRs) implicated in the activation of many physiological mechanisms. Thus, thrombin activates many cell types such as vascular smooth muscle cells, leukocytes, endothelial cells, and platelets via activation of …

pl, fr (code pays fourni par la source)