Frédéric Finana

Innovative Bioluminescence Resonance Energy Transfer Assay Reveals Differential Agonist-Induced D2 Receptor Intracellular Trafficking and Arrestin-3 Recruitment

Luc De Vries, Frédéric Finana, Claudie Cathala, Brice Ronsin et autres

fr (code pays fourni par la source)

An internalization assay for Dopamine D2(short) Receptors using Bioluminescence Resonance Energy Transfer (BRET) technology

Luc De Vries, Frédéric Finana, Claudie Cathala, Brice Ronsin et autres

Internalization and subsequent degradation of GPCRs located at the plasmamembrane represent a desired therapeutic approach to eliminate those receptors whose activation leads to unwanted cellular behaviour. In order to follow the trafficking of endocytosed receptors and thus the efficacy of agents directing …

fr (code pays fourni par la source)

Dosage‐dependent regulation of cell proliferation and adhesion through dual β 2 ‐adrenergic receptor/cAMP signals

Ariana Bruzzone, Aude Saulière, Frédéric Finana, Jean‐Michel Sénard et autres

The role of β-adrenergic receptors (β-ARs) remains controversial in normal and tumor breast. Herein we explore the cAMP signaling involved in β-AR-dependent control of proliferation and adhesion of nontumor human breast cell line MCF-10A. Low concentrations of a β-agonist, isoproterenol (ISO), promote …

ar, fr (code pays fourni par la source)

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

Aude Saulière, Morgane Bellot, Hervé Paris, Colette Denis et autres

fr, dk (code pays fourni par la source)

μ-opioid and 5-HT1A receptors heterodimerize and show signalling crosstalk via G protein and MAP-kinase pathways

Didier Cussac, Isabelle Rauly‐Lestienne, Peter Heusler, Frédéric Finana et autres

fr (code pays fourni par la source)

Cellular BRET assay suggests a conformational rearrangement of preformed TrkB/Shc complexes following BDNF-dependent activation

Luc De Vries, Frédéric Finana, Frédéric Cachoux, Bernard Vacher et autres

fr (code pays fourni par la source)

Mutant 5-Hydroxytryptamine1A Receptor D116A Is a Receptor Activated Solely by Synthetic Ligands with a Rich Pharmacology

Didier Cussac, Christiane Palmier, Frédéric Finana, Luc De Vries et autres

fr (code pays fourni par la source)

Pharmacological characterization of protease activated receptor-1 by a serum responsive element-dependent reporter gene assay: Major role of calmodulin

Luc De Vries, Christiane Palmier, Frédéric Finana, Bruno Le Grand et autres

fr (code pays fourni par la source)

Endogenous RGS proteins facilitate dopamine D2S receptor coupling to Gαo proteins and Ca2+ responses in CHO‐K1 cells

Elisa A. Boutet-Robinet, Frédéric Finana, Thierry Wurch, Petrus J. Pauwels et autres

The role of RGS proteins on dopaminergic D2S receptor (D2SR) signalling was investigated in Chinese hamster ovary (CHO)-K1 cells, using recombinant RGS protein- and PTX-insensitive G alphao proteins. Dopamine-mediated [35S]GTPgammaS binding was attenuated by more than 60% in CHO-K1 D2SR cells coexpressing …

de, fr (code pays fourni par la source)

Analysis of ligand activation of α 2 -adrenoceptor subtypes under conditions of equal G α protein stoichiometry

Petrus J. Pauwels, Thierry Wurch, Stéphanie Tardif, Frédéric Finana et autres

fr (code pays fourni par la source)

Dynamic Dopamine-Antagonist Interactions at Recombinant Human Dopamine D2short Receptor: Dopamine-Bound versus Antagonist-Bound Receptor States

Petrus J. Pauwels, Frédéric Finana, Thierry Wurch, F. C. Colpaert

fr (code pays fourni par la source)

Agonist efficacy at the α 2A -adrenoceptor:G α 15 fusion protein: an analysis based on Ca 2+ responses

Petrus J. Pauwels, Frédéric Finana, Stéphanie Tardif, Françis C. Colpaert et autres

fr (code pays fourni par la source)