Ancély Ferreira dos Santos

HMOX1 controls a heme-ferritin switch that protects cells from ferroptosis

Izadora de Souza, Izabela Amélia Marques de Andrade, Florêncio Porto Freitas, Ana Beatriz da Silva Teixeira et autres

Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One of the main contributors to LIP is heme catabolism mediated by heme oxygenase-1 …

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Tipping the balance: NRF2’s dual role in ferroptotic fate

Izadora de Souza, Ana Beatriz da Silva Teixeira, Ancély Ferreira dos Santos, José Pedro Friedmann Ângeli et autres

The NRF2 pathway has emerged as a central regulator of cellular redox homeostasis, coordinating the expression of a broad array of genes that protect cells from oxidative and electrophilic stress. In the context of cancer, NRF2 has been recognized as a key …

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Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Florêncio Porto Freitas, Hamed Alborzinia, Ancély Ferreira dos Santos, Palina Nepachalovich et autres

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Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

Vera Skafar, Izadora de Souza, Biplab Ghosh, Ancély Ferreira dos Santos et autres

Abstract Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. More recently, ferroptosis suppressor protein 1 (FSP1) was identified as a critical ferroptosis inhibitor, acting …

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What lies beyond thioredoxin reductase? Cyclometallated gold compounds reveal Sec selectivity in glutathione peroxidases

Ioannis Kanavos, Douglas Hideki Nakahata, Madeleine S. Barrett, Ancély Ferreira dos Santos et autres

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PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

Zhiyi Chen, Alex Inague, Kamini Kaushal, Gholamreza Fazeli et autres

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

Vera Skafar, Izadora de Souza, Ancély Ferreira dos Santos, Florêncio Porto Freitas et autres

Abstract Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficiencies in these protective systems lead to an increased propensity to phospholipid peroxidation and ferroptosis. …

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Organelle conversations drive ferroptosis

Ancély Ferreira dos Santos, José Pedro Friedmann Angeli

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Selective Arylation of Se vs. S by Gold Compounds: Consequences for GPx Inhibition and A375 Sensitivity

Ioannis Kanavos, Douglas Hideki Nakahata, Madeleine S. Barrett, Ancély Ferreira dos Santos et autres

In this study, cyclometallated gold(III) compounds were evaluated for their capability to promote C-Se coupling reactions under biocompatible conditions, and their chemoselectivity towards selenium-containing substrates compared to sulfur-containing analogs. The compounds exhibited varying degrees of selectivity towards selenium-containing compounds, with [Au(bnopy)Cl₂] showing …

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P.1 and P.2 SARS-CoV-2 Brazilian variants activate the unfolded protein response with a time and pathway specificity

Vinícius M. Gomes, Deivid Martins Santos, Janaína Macedo da Silva, Lucas Cardoso Lázari et autres

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PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

Zhiyi Chen, Alex Inague, Kamini Kaushal, Gholamreza Fazeli et autres

Selenocysteine (Sec) metabolism is crucial for cellular function and ferroptosis prevention and begins with the uptake of the Sec carrier, selenoprotein P (SELENOP). Following uptake, Sec released from SELENOP is metabolized via selenocysteine lyase (SCLY), producing selenide, a substrate for selenophosphate synthetase …

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Troubling bonds: lipid unsaturation promotes selenium dependency and sensitivity to ferroptosis

Ancély Ferreira dos Santos, José Pedro Friedmann Angeli

Cancer cells exhibit a remarkable ability to orchestrate metabolic adaptations to survive and proliferate. Such metabolic adaptations, including carbohydrates, amino acids and lipid metabolism, have been shown to also contribute to the pathological cascade during cancer progression and therapy resistance. Importantly, these …

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