Jingru Qu

Plin5 alleviates endoplasmic reticulum stress to promote white adipose tissue remodeling

Jingru Qu, Yahui Miao, Ting Li, Lei Tian et autres

Obesity is characterized by impaired white adipose tissue (WAT) remodeling, dysregulated lipid metabolism, and chronic endoplasmic reticulum (ER) stress. Perilipin 5 (Plin5), a lipid droplet-associated protein, has been implicated in lipid metabolism and ER homeostasis, but its role in WAT remodeling remains …

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TEAD1 signaling modulates adrenal chromaffin cell maturation

Longqing Xia, Xue Liu, Fei Yan, Jingru Qu et autres

ABSTRACT Chromaffin cells synthesize and secrete catecholamines to coordinate systemic stress responses and regulate diverse neuroendocrine and metabolic functions. However, the molecular mechanisms governing chromaffin-cell differentiation and their disruption in pheochromocytoma (PC) remain incompletely understood. Here, through integrated analyses of human developmental …

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BRD4 Signaling Maintains the Differentiated State of β Cells

Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun et autres

In diabetes, pancreatic β cells degenerate from their mature differentiated state to a dedifferentiated state. BRD4 plays a pivotal role during embryogenesis and cancer development, but its function in modulating β-cell differentiation remains unknown. In this study, multiple models including calorie restriction …

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Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC‑1α pathway in diabetic nephropathy

Shengnan Sun, Shurong Yang, Ying Cheng, Ting Fang et autres

Traditional Chinese Medicine (TCM) has demonstrated promising efficacy in managing and preventing the early‑stage diabetic nephropathy (DN). Although the exact mechanisms remain elusive, clinical evidence has suggested that Jinlida granules (JLD) are beneficial in improving renal function among patients with DN. The …

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SGLT2 inhibitor canagliflozin reduces visceral adipose tissue in db/db mice by modulating AMPK/KLF4 signaling and regulating mitochondrial dynamics to induce browning

Jingru Qu, Lei Tian, Man Zhang, Bei Sun et autres

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RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis

Chaofei Xu, Ting Fang, Jingru Qu, Yahui Miao et autres

BACKGROUND & AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a dynamic chronic liver disease closely related to metabolic abnormalities such as diabetes and obesity. MASLD can further progress to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC). However, …

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Jinlida Granules Attenuate Podocyte Apoptosis in Diabetic Nephropathy by Improving Mitochondrial Dysfunction Through Activation of the Ampk/Pgc-1α Pathway

Shengnan Sun, Shurong Yang, Xiangna Chen, Ting Fang et autres

Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease

Chao Tang, Xiucong Deng, Jingru Qu, Yahui Miao et autres

Background: Diabetic kidney disease (DKD) is a major diabetic microvascular complication. Fatty acid-induced lipotoxicity and apoptosis were associated with the exacerbation of DKD. However, the association of lipotoxicity with renal tubular apoptosis and the effects of fenofibrate on DKD are not fully …

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Corneal Nerve Parameter Reference Values for Chinese Adults Assessed by Corneal Confocal Microscopy

Juan Cao, Jingru Qu, Bekzod Odilov, Bin Lü et autres

Background. Confocal corneal microscopy is an excellent new noninvasive tool for assessing diabetic peripheral neuropathy. We aimed to investigate the clinical variables associated with corneal nerve parameters and establish reference values for clinical use in healthy Chinese adults. Methods. The study enlisted …

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Clinical and Functional Characteristics of a Novel KLF11 Cys354Phe Variant Involved in Maturity-Onset Diabetes of the Young

Yujing Sun, Jingru Qu, Jing Wang, Ruxing Zhao et autres

Background. Mutations in human KLF11 may lead to the development of maturity-onset diabetes of the young 7 (MODY7). This occurs due to impaired insulin synthesis in the pancreas. To date, the clinical and functional characteristics of the novel KLF11 mutation c.1061G > …

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The Association of Fasting C-peptide with Corneal Neuropathy in Patients with Type 2 Diabetes

Anju Zuo, Chuan Wang, Lili Li, Jingru Qu et autres

Purpose. Damage to corneal nerve fibers has been demonstrated in people with type 2 diabetes mellitus (T2DM) that further progresses with increasing severity of diabetic peripheral neuropathy. However, the role of C-peptide in corneal nerve damage has not been reported in T2DM. …

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